Increase in Trx2/Prx3 redox system immunoreactivity in the spinal cord and hippocampus of aged dogs

Experimental Gerontology

Volumn 46, Issue 11, 2011, Pages 946-952

  Ahn, Ji Hyeon ^a   Choi, Jung Hoon ^b   Song, Ju Min ^a   Lee, Choong Hyun ^c   Yoo, Ki Yeon ^d   Hwang, In Koo ^c   Kim, Jin Sang ^a   Shin, Hyung Cheul ^e   Won, Moo Ho ^b  

^a Daegu University   (South Korea)

^b Kangwon National University   (South Korea)

^c Seoul National University   (South Korea)

^d Gangneung Wonju National University   (South Korea)

^e Hallym University   (South Korea)

Author keywords

Aging; Hippocampus; Peroxiredoxin 3; Spinal gray matter; Thioredoxin 2; Thioredoxin reductase 2

Indexed keywords

PEROXIREDOXIN 3; THIOREDOXIN 2; THIOREDOXIN REDUCTASE 2;

ADULT ANIMAL; AGED; ANIMAL TISSUE; ARTICLE; CERVICAL SPINAL CORD; CONTROLLED STUDY; CYTOPLASM; DENTATE GYRUS; DOG; GRANULE CELL; GRAY MATTER; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LUMBAR SPINAL CORD; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PYRAMIDAL NERVE CELL; SPINAL CORD; WESTERN BLOTTING;

AGING; ANIMALS; DOGS; HIPPOCAMPUS; HYDROGEN PEROXIDE; MALE; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEROXIREDOXIN III; SPINAL CORD; THIOREDOXINS;

CANIS FAMILIARIS;

EID: 80054850136     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2011.08.004     Document Type: Article

References (50)

1. Ahn J.H., Choi J.H., Kim J.S., Lee H.J., Lee C.H., Yoo K.Y., Hwang I.K., Lee Y.L., Shin H.C., Won M.H. Comparison of immunoreactivities in 4-HNE and superoxide dismutases in the cervical and the lumbar spinal cord between adult and aged dogs. Exp. Gerontol. 2011, 46:703-708.
2. Akterin S., Cowburn R.F., Miranda-Vizuete A., Jiménez A., Bogdanovic N., Winblad B., Cedazo-Minguez A. Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease. Cell Death Differ. 2006, 13:1454-1465.
3. Aon-Bertolino M.L., Romero J.I., Galeano P., Holubiec M., Badorrey M.S., Saraceno G.E., Hanschmann E.M., Lillig C.H., Capani F. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Biochim. Biophys. Acta 2011, 1810:93-110.
4. Berlett B.S., Stadtman E.R. Protein oxidation in aging, disease, and oxidative stress. J. Biol. Chem. 1997, 272:20313-20316.
5. Chae H.Z., Kim H.J., Kang S.W., Rhee S.G. Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin. Diabetes Res. Clin. Pract. 1999, 45:101-112.
6. Chen X., Stern D., Yan S.D. Mitochondrial dysfunction and Alzheimer's disease. Curr. Alzheimer Res. 2006, 3:515-520.
7. Chen L., Na R., Gu M., Salmon A.B., Liu Y., Liang H., Qi W., Van Remmen H., Richardson A., Ran Q. Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice. Aging Cell 2008, 7:866-878.
8. Chen Y., Go Y.M., Pohl J., Reed M., Cai J., Jones D.P. Increased mitochondrial thioredoxin 2 potentiates N-ethylmaleimide-induced cytotoxicity. Chem. Res. Toxicol. 2008, 21:1205-1210.
9. Cox A.G., Winterbourn C.C., Hampton M.B. Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochem. J. 2010, 425:313-325.
10. Cui K., Luo X., Xu K., Ven Murthy M.R. Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants. Prog. Neuropsychopharmacol. Biol. Psychiatry 2004, 28:771-799.
11. Desai K.M., Chang T., Wang H., Banigesh A., Dhar A., Liu J., Untereiner A., Wu L. Oxidative stress and aging: is methylglyoxal the hidden enemy?. Can. J. Physiol. Pharmacol. 2010, 88:273-284.
12. Drechsel D.A., Patel M. Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system. J. Biol. Chem. 2010, 285:27850-27858.
13. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 2000, 408:239-247.
14. Fujii J., Ikeda Y. Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox Rep. 2002, 7:123-130.
15. Giorgio M., Trinei M., Migliaccio E., Pelicci P.G. Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?. Nat. Rev. Mol. Cell Biol. 2007, 8:722-728.
16. Godoy J.R., Oesteritz S., Hanschmann E.M., Ockenga W., Ackermann W., Lillig C.H. Segment-specific overexpression of redoxins after renal ischemia and reperfusion: protective roles of glutaredoxin 2, peroxiredoxin 3, and peroxiredoxin 6. Free Radic. Biol. Med. 2011, 51:552-561.
17. Halliwell B. Reactive oxygen species and the central nervous system. J. Neurochem. 1992, 59:1609-1623.
18. Hattori F., Murayama N., Noshita T., Oikawa S. Mitochondrial peroxiredoxin-3 protects hippocampal neurons from excitotoxic injury in vivo. J. Neurochem. 2003, 86:860-868.
19. Head E. Neurobiology of the aging dog. Age (Dordr) 2010, 10.1007/s11357-010-9183-3.
20. Hirota K., Murata M., Sachi Y., Nakamura H., Takeuchi J., Mori K., Yodoi J. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. J. Biol. Chem. 1999, 274:27891-27897.
21. Hwang I.K., Yoon Y.S., Yoo K.Y., Li H., Choi J.H., Kim D.W., Yi S.S., Seong J.K., Lee I.S., Won M.H. Differences in lipid peroxidation and Cu, Zn-superoxide dismutase in the hippocampal CA1 region between adult and aged dogs. J. Vet. Med. Sci. 2008, 70:273-277.
22. Hwang I.K., Yoo K.Y., Kim D.W., Lee C.H., Choi J.H., Kwon Y.G., Kim Y.M., Choi S.Y., Won M.H. Changes in the expression of mitochondrial peroxiredoxin and thioredoxin in neurons and glia and their protective effects in experimental cerebral ischemic damage. Free Radic. Biol. Med. 2010, 48:1242-1251.
23. Jia J., Zhang X., Hu Y.S., Wu Y., Wang Q.Z., Li N.N., Wu C.Q., Yu H.X., Guo Q.C. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Thromb. Res. 2009, 123:727-730.
24. Kang S.W., Rhee S.G., Chang T.S., Jeong W., Choi M.H. 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications. Trends Mol. Med. 2005, 11:571-578.
25. Kato S., Saeki Y., Aoki M., Nagai M., Ishigaki A., Itoyama Y., Kato M., Asayama K., Awaya A., Hirano A., Ohama E. Histological evidence of redox system breakdown caused by superoxide dismutase 1 (SOD1) aggregation is common to SOD1-mutated motor neurons in humans and animal models. Acta Neuropathol. 2004, 107:149-158.
26. Klein J.A., Ackerman S.L. Oxidative stress, cell cycle, and neurodegeneration. J. Clin. Invest. 2003, 111:785-793.
27. Kokoszka J.E., Coskun P., Esposito L.A., Wallace D.C. Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:2278-2283.
28. Kong L., Zhou X., Li F., Yodoi J., McGinnis J., Cao W. Neuroprotective effect of overexpression of thioredoxin on photoreceptor degeneration in Tubby mice. Neurobiol. Dis. 2010, 38:446-455.
29. Lee C.H., Yan B., Yoo K.Y., Choi J.H., Kwon S.H., Her S., Sohn Y., Hwang I.K., Cho J.H., Kim Y.M., Won M.H. Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia. J. Neurosci. Res. 2011, 89:1103-1113.
30. Masutani H., Bai J., Kim Y.C., Yodoi J. Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection. Mol. Neurobiol. 2004, 29:229-242.
31. Matés J.M., Pérez-Gómez C., Núñez de Castro I. Antioxidant enzymes and human diseases. Clin. Biochem. 1999, 32:595-603.
32. + current are regulated by thioredoxin. Am. J. Physiol. Cell Physiol. 2007, 293:C211-C217.
33. Munemasa Y., Kim S.H., Ahn J.H., Kwong J.M., Caprioli J., Piri N. Protective effect of thioredoxins 1 and 2 in retinal ganglion cells after optic nerve transection and oxidative stress. Invest. Ophthalmol. Vis. Sci. 2008, 49:3535-3543.
34. Mustacich D., Powis G. Thioredoxin reductase. Biochem. J. 2000, 346(Pt 1):1-8.
35. Nordberg J., Arnér E.S. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic. Biol. Med. 2001, 31:1287-1312.
36. +-dependent skeletal muscle contraction in senescent mice. Exp. Gerontol. 2007, 42:309-319.
37. Rhee S.G., Chae H.Z., Kim K. Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic. Biol. Med. 2005, 38:1543-1552.
38. Rodrigues de Amorim M.A., Garcia-Segura L.M., Goya R.G., Portiansky E.L. Decrease in PTEN and increase in Akt expression and neuron size in aged rat spinal cord. Exp. Gerontol. 2010, 45:457-463.
39. Rybnikova E., Damdimopoulos A.E., Gustafsson J.A., Spyrou G., Pelto-Huikko M. Expression of novel antioxidant thioredoxin-2 in the rat brain. Eur. J. Neurosci. 2000, 12:1669-1678.
40. Schmued L.C., Hopkins K.J. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 2000, 874:123-130.
41. Seyfried J., Wüllner U. Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway. Biochem. Biophys. Res. Commun. 2007, 359:759-764.
42. Shigenaga M.K., Hagen T.M., Ames B.N. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:10771-10778.
43. Siwak-Tapp C.T., Head E., Muggenburg B.A., Milgram N.W., Cotman C.W. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol. Aging 2008, 29:39-50.
44. Tanaka T., Hosoi F., Yamaguchi-Iwai Y., Nakamura H., Masutani H., Ueda S., Nishiyama A., Takeda S., Wada H., Spyrou G., Yodoi J. Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBO J. 2002, 21:1695-1703.
45. Turoczi T., Chang V.W., Engelman R.M., Maulik N., Ho Y.S., Das D.K. Thioredoxin redox signaling in the ischemic heart: an insight with transgenic mice overexpressing Trx1. J. Mol. Cell. Cardiol. 2003, 35:695-704.
46. Wang L., Jiang D.M. Neuroprotective effect of Buyang Huanwu Decoction on spinal ischemia/reperfusion injury in rats. J. Ethnopharmacol. 2009, 124:219-223.
47. Wood Z.A., Schröder E., Robin Harris J., Poole L.B. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem. Sci. 2003, 28:32-40.
48. Wood-Allum C.A., Barber S.C., Kirby J., Heath P., Holden H., Mead R., Higginbottom A., Allen S., Beaujeux T., Alexson S.E., Ince P.G., Shaw P.J. Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Brain 2006, 129:1693-1709.
49. Zhang H., Go Y.M., Jones D.P. Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress. Arch. Biochem. Biophys. 2007, 465:119-126.
50. Zhong L., Holmgren A. Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations. J. Biol. Chem. 2000, 275:18121-18128.