Early cognitive development in children born to women with epilepsy: A prospective report

Epilepsia

Volumn 51, Issue 10, 2010, Pages 2058-2065

  Bromley, Rebecca L ^a   Mawer, George ^b   Love, Jenna ^a   Kelly, James ^a   Purdy, Laura ^a   McEwan, Lauren ^a   Briggs, Maria ^b   Smith, Jill Clayton ^b   Sin, Xin ^c   Baker, Gus A ^a  

^a Clinical Sciences Centre for Research and Education   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

Antiepileptic drugs; Cognitive development; Epilepsy; In utero exposure; Pregnancy; Women

Indexed keywords

CARBAMAZEPINE; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENYTOIN; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

ADULT; ARTICLE; CHILD; COGNITIVE DEVELOPMENT; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EPILEPSY; FEMALE; FOCAL EPILEPSY; GENERALIZED EPILEPSY; GRAND MAL EPILEPSY; GRIFFITHS MENTAL DEVELOPMENT SCALE; HOME; HOSPITAL; HUMAN; INFANT; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MOTHER; MYOCLONUS EPILEPSY; NEUROPSYCHOLOGICAL TEST; PERINATAL DRUG EXPOSURE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOLOGIC ASSESSMENT; RISK; SOCIAL STATUS;

AGE FACTORS; ANTICONVULSANTS; CHILD; CHILD OF IMPAIRED PARENTS; COGNITION; COGNITION DISORDERS; DEVELOPMENTAL DISABILITIES; EPILEPSY; FEMALE; HUMANS; INFANT; INTELLIGENCE; MOTHERS; NEUROPSYCHOLOGICAL TESTS; PREGNANCY; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; RISK FACTORS; SOCIAL CLASS; VALPROIC ACID;

EID: 78649231218     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2010.02668.x     Document Type: Article

References (24)

1. Ackers R, Besag F, Wade A, Murray M, Wong I,. (2009) Changing trends in antiepileptic drug prescription in girls of child-bearing potential. Arch Dis Child 443: 447.
2. Adab N, Kini U, Vinten J, Ayres J, Baker G, Clayton-Smith J, Coyle H, Fryer A, Gorry J, Gregg J, Mawer G, Nicolaides P, Pickering L, Tunnicliffe L, Chadwick DW,. (2004) The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry, 75: 1575-1583.
3. Bromley R, Mawer G, Clayton-Smith J, Baker GA,; on Behalf of the Liverpool and Manchester Neurodevelopment Group. (2008) Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology, 71: 1923-1924.
4. Bromley R, Baker G, Meador K,. (2009a) Cognitive abilities and behaviour of children exposed to antiepileptic drugs in utero. Curr Opin Neurol, 22: 162-166.
5. Bromley R, Gummery A, Shallcross R, Briggs M, Mawer G, Clayton-Smith J, Baker G,. (2009b) IQ, memory, language and attention in children exposed to antiepileptic drugs in utero: preliminary outcomes at 6 years of age. Epilepsia, 50 (Suppl 11): 491.
6. Gaily E, Kantola-Sorsa E, Hiilesmaa V, Isoaho M, Matila R, Kotila M, Nylund T, Bardy A, Kaaja E, Granstrom ML,. (2004) Normal intelligence in children with prenatal exposure to carbamazepine. Neurology, 62: 28-32.
7. Hattig H, Steinhausen HC,. (1987) Children of epileptic parents: a prospective developmental study. In, Rauh H, Steinhausen HC, (Eds) Psychobiology and early development. Elsevier, Amsterdam, pp. 155-169.
8. Hirst J, Formby E, Owen J,. 2006. Pathways to parenthood: reflections from three generations of teenage mothers and fathers. Sheffield Health and Social Research Consortium 2006. Sheffield Hallam University Press, Sheffield.
9. Huntley M,. 1996, The Griffiths mental development scales: from birth to 2 years, 2nd ed. The Test Agency Limited, Oxford.
10. Jones K, Lacro RV, Johnson KA, Adams J,. (1989) Pattern of malformations in the children of women treated with carbamazepine during pregnancy. N Eng J Med, 320: 1661-1666.
11. Kantola-Sorsa E, Gaily E, Isoaho M, Korkman M,. (2007) Neuropsychological outcomes in children of mothers with epilepsy. J Int Neuropsychol Soc 13: 642-652.
12. Mawer G, Briggs M, Baker GA, Bromley R, Coyle H, Eatock J, Kerr L, Kini U, Kuzmyshcheva L, Lucas S, Wyatt L, Clayton-Smith J,; On Behalf of the Liverpool and Manchester Neurodevelopment Group. (2010) Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study. Seizure 19: 112-119.
13. Meador K, Baker G, Browning N, Clayton-Smith J, Combs-Cantrell D, Cohen M, Kalayjian L, Kanner A, Liporace J, Pennell P, Privitera M, Loring D,. (2009) Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N Eng J Med, 360: 1597-1605.
14. Moore SJ, Turnpenny PD, Quinn A, Glover S, Lloyd DJ, Montgomery T, Dean JCS,. (2000) A clinical study of 57 children with fetal anticonvulsant syndromes. J Med Genet, 37: 489-497.
15. Nelson H,. 1990, The national adult reading test. Nfer-Nelson Publishing, London.
16. Nicolai J, Vles JSH, Aldenkamp AP,. (2008) Neurodevelopmental delay in children exposed to antiepileptic drugs in utero: a critical review directed at structural study-bias. J Neurol Sci, 271: 1-14.
17. Ornoy A, Cohen E,. (1996) Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy. Arch Dis Child, 75: 517-520.
18. Rovet J, Cole S, Nulman I, Scolnik D, Altmann D, Koren G,. (1995) Effects of maternal epilepsy on children's neurodevelopment. Neuropsychology, 1: 150-157.
19. Samren EB, Van Duijn CM, Koch S, Hiilesmaa VK, Klepel H, Bardy AH, Mannagetta GB, Deichl AW, Gaily E, Granstrom ML, Meinardi H, Grobbee DE, Hofman A, Janz D, Lindhout D,. (1997) Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy. Epilepsia, 38: 981-990.
20. Stiles J,. (2008) The fundaments of brain development: integrating nature and nurture. Harvard University Press, Cambridge.
21. Thomas SV, Sukumaran S, Lukose N, George A, Sarma PS,. (2007) Intellectual and language functions in children of mothers with epilepsy. Epilepsia, 48: 2234-2240.
22. Thomas S, Ajaykumar B, Sindhu K, Nair MGB, Sarma P,. (2008) Motor and mental development of infants exposed to antiepileptic drugs in utero. Epilepsy Behav, 13: 229-236.
23. Titze K, Koch S, Helge H, Lehmkuhl U, Rauh H, Steinhausen HC,. (2008) Prenatal and family risks of children born to mothers with epilepsy: effects on cognitive development. Dev Med Child Neurol, 50: 117-122.
24. Vinten J, Adab N, Kini U, Gorry J, Gregg J, Baker GA,; Liverpool and Manchester Neurodevelopment Study Group. (2005) Neuropsychological effects of exposure to anticonvulsant medication in utero. Neurology 64: 949-954.