메뉴 건너뛰기




Volumn 30, Issue 5, 2011, Pages 568-582

The role of the toxicologic pathologist in the biopharmaceutical industry

(12)  Van Tongeren, Susan a   Fagerland, Jane A b   Conner, Michael W c   Diegel, Kelly d   Donnelly, Kevin e   Grubor, Branka f   Lopez Martinez, Alric g   Bolliger, Anne Provencher h   Sharma, Alok i   Tannehill Gregg, Sarah j   Turner, Patricia V k   Wancket, Lyn M l  


Author keywords

biopharmaceuticals; career development; drug development; toxicologic pathology

Indexed keywords

CAREER; CONFERENCE PAPER; DRUG INDUSTRY; DRUG RESEARCH; EDUCATION PROGRAM; HUMAN; PATHOLOGIST; SCIENCE; STAFF TRAINING; TOXICITY TESTING;

EID: 80054826263     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581811413304     Document Type: Conference Paper
Times cited : (29)

References (76)
  • 1
    • 68649123564 scopus 로고    scopus 로고
    • Global recognition of qualified toxicologic pathologists: Credential review as a potential route for recognizing the proficiency of pathologists involved in regulatory-type nonclinical studies
    • Ettlin RA, Bolon B, Pyrah I, Konishi Y, Black HE. Global recognition of qualified toxicologic pathologists: credential review as a potential route for recognizing the proficiency of pathologists involved in regulatory-type nonclinical studies. Toxicol Pathol. 2009 ; 37 (4). 553-561
    • (2009) Toxicol Pathol , vol.37 , Issue.4 , pp. 553-561
    • Ettlin, R.A.1    Bolon, B.2    Pyrah, I.3    Konishi, Y.4    Black, H.E.5
  • 2
    • 77953620270 scopus 로고    scopus 로고
    • Global recognition of qualified toxicologic pathologists: Credential review as a potential route for recognizing the proficiency of pathologists involved in regulatory-type nonclinical studies
    • Ettlin RA, Bolon B, Pyrah I, Konishi Y, Black HE. Global recognition of qualified toxicologic pathologists: credential review as a potential route for recognizing the proficiency of pathologists involved in regulatory-type nonclinical studies. Exp Toxicol Pathol. 2010 ; 62 (4). 413-422
    • (2010) Exp Toxicol Pathol , vol.62 , Issue.4 , pp. 413-422
    • Ettlin, R.A.1    Bolon, B.2    Pyrah, I.3    Konishi, Y.4    Black, H.E.5
  • 3
    • 84857503971 scopus 로고    scopus 로고
    • American College of Veterinary Pathologists Accessed October 19
    • American College of Veterinary Pathologists. American College of Veterinary Pathologists 2006 Salary Survey. 2007; http://www.acvp.org/news/ salsurv/ACVP-2006-Salary-Survey.pdf. Accessed October 19, 2010.
    • (2007) American College of Veterinary Pathologists 2006 Salary Survey
  • 4
    • 49749089723 scopus 로고    scopus 로고
    • Global recognition of qualified toxicologic pathologists: Where we are now and where we need to go
    • Ettlin RA, Bolon B, Pyrah I, Konishi Y, Black HE. Global recognition of qualified toxicologic pathologists: where we are now and where we need to go. Toxicol Pathol. 2008 ; 36 (5). 753-759
    • (2008) Toxicol Pathol , vol.36 , Issue.5 , pp. 753-759
    • Ettlin, R.A.1    Bolon, B.2    Pyrah, I.3    Konishi, Y.4    Black, H.E.5
  • 5
    • 43849083418 scopus 로고    scopus 로고
    • Global recognition of qualified toxicologic pathologists: Where we are now and where we need to go
    • Ettlin RA, Bolon B, Pyrah I, Konishi Y, Black HE. Global recognition of qualified toxicologic pathologists: where we are now and where we need to go. Exp Toxicol Pathol. 2008 ; 60 (1). 1-8
    • (2008) Exp Toxicol Pathol , vol.60 , Issue.1 , pp. 1-8
    • Ettlin, R.A.1    Bolon, B.2    Pyrah, I.3    Konishi, Y.4    Black, H.E.5
  • 6
    • 37648999297 scopus 로고    scopus 로고
    • Future directions in training veterinarians for careers in toxicological pathology in the United Kingdom
    • Scudamore CL, Smith SH. Future directions in training veterinarians for careers in toxicological pathology in the United Kingdom. J Vet Med Educ. 2007 ; 34 (4). 450-457
    • (2007) J Vet Med Educ , vol.34 , Issue.4 , pp. 450-457
    • Scudamore, C.L.1    Smith, S.H.2
  • 7
    • 78649915697 scopus 로고    scopus 로고
    • International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies
    • Bolon B, Barale-Thomas E, Bradley A, et al. International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies. Toxicol Pathol. 2010 ; 38 (6). 984-992
    • (2010) Toxicol Pathol , vol.38 , Issue.6 , pp. 984-992
    • Bolon, B.1    Barale-Thomas, E.2    Bradley, A.3
  • 9
    • 80054813353 scopus 로고
    • Arnold L. Toxicity of calcium phosphate precipitate and urinary amorphous precipitate toward rat bladder epithelial cells
    • Cohen S, Mann A, Lear C, Mattson B. Arnold L. Toxicity of calcium phosphate precipitate and urinary amorphous precipitate toward rat bladder epithelial cells. Proc Am Assoc Cancer Res. 1995 ; 178: 36
    • (1995) Proc Am Assoc Cancer Res , vol.178 , pp. 36
    • Cohen, S.1    Mann, A.2    Lear, C.3    Mattson, B.4
  • 10
    • 0034091676 scopus 로고    scopus 로고
    • Calcium phosphate-containing precipitate and the carcinogenicity of sodium salts in rats
    • Cohen SM, Arnold LL, Cano M, Ito M, Garland EM, Shaw RA. Calcium phosphate-containing precipitate and the carcinogenicity of sodium salts in rats. Carcinogenesis. 2000 ; 21 (4). 783-792 (Pubitemid 30214037)
    • (2000) Carcinogenesis , vol.21 , Issue.4 , pp. 783-792
    • Cohen, S.M.1    Arnold, L.L.2    Cano, M.3    Ito, M.4    Garland, E.M.5    Shaw, R.A.6
  • 12
    • 0029129394 scopus 로고
    • Role of urinary physiology and chemistry in bladder carcinogenesis
    • Cohen SM. Role of urinary physiology and chemistry in bladder carcinogenesis. Food Chem Toxicol. 1995 ; 33 (9). 715-730
    • (1995) Food Chem Toxicol , vol.33 , Issue.9 , pp. 715-730
    • Cohen, S.M.1
  • 13
    • 0025996037 scopus 로고
    • Quantitation of urinary alpha 2u-globulin and albumin by reverse-phase high performance liquid chromatography
    • Lehman-McKeeman LD, Caudill D. Quantitation of urinary alpha 2u-globulin and albumin by reverse-phase high performance liquid chromatography. J Pharmacol Methods. 1991 ; 26 (4). 239-247
    • (1991) J Pharmacol Methods , vol.26 , Issue.4 , pp. 239-247
    • Lehman-Mckeeman, L.D.1    Caudill, D.2
  • 14
    • 67049088308 scopus 로고    scopus 로고
    • Strain-related differences in urine composition of male rats of potential relevance to urolithiasis
    • Tannehill-Gregg SH, Dominick MA, Reisinger AJ, et al. Strain-related differences in urine composition of male rats of potential relevance to urolithiasis. Toxicol Pathol. 2009 ; 37 (3). 293-305
    • (2009) Toxicol Pathol , vol.37 , Issue.3 , pp. 293-305
    • Tannehill-Gregg, S.H.1    Dominick, M.A.2    Reisinger, A.J.3
  • 15
    • 0003002818 scopus 로고    scopus 로고
    • 5th ed. McGraw-Hill Professional, New York; 1996:617-640. Klaassen CD, ed. New York: McGraw-Hill Professional
    • Capen C Casarett & Doulls Toxicology: The Basic Science of Poisons. 5 th ed. McGraw-Hill Professional, New York; 1996:617-640. Klaassen CD, ed. New York: McGraw-Hill Professional ; 1996: 617-640.
    • (1996) Casarett & Doulls Toxicology: The Basic Science of Poisons , pp. 617-640
    • Capen, C.1
  • 16
    • 0025863054 scopus 로고
    • The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland
    • Curran PG, DeGroot LJ. The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland. Endocr Rev. 1991 ; 12 (2). 135-150
    • (1991) Endocr Rev , vol.12 , Issue.2 , pp. 135-150
    • Curran, P.G.1    Degroot, L.J.2
  • 17
    • 47649124350 scopus 로고    scopus 로고
    • Veterinary clinical pathologists in the biopharmaceutical industry
    • DOI 10.1111/j.1939-165X.2008.00041.x
    • Schultze AE, Bounous DI, Bolliger AP. Veterinary clinical pathologists in the biopharmaceutical industry. Vet Clin Pathol. 2008 ; 37 (2). 146-158 (Pubitemid 352017739)
    • (2008) Veterinary Clinical Pathology , vol.37 , Issue.2 , pp. 146-158
    • Schultze, A.E.1    Bounous, D.I.2    Bolliger, A.P.3
  • 19
    • 80054802740 scopus 로고    scopus 로고
    • Bilateral optic atrophy in cynomolgus monkeys
    • Leedle R, Dubielzig R, Christian B. Bilateral optic atrophy in cynomolgus monkeys. Veterinary Pathol. 2008 ; 45 (5). 781
    • (2008) Veterinary Pathol , vol.45 , Issue.5 , pp. 781
    • Leedle, R.1    Dubielzig, R.2    Christian, B.3
  • 20
    • 80054805535 scopus 로고    scopus 로고
    • Light microscopic changes of sciatic nerve in control beagle dogs in toxicity studies
    • Whitney K, Schwartz A, OConnor J, Foley G, Garman R. Light microscopic changes of sciatic nerve in control beagle dogs in toxicity studies. Veterinary Pathol. 2009 ; 1081: 46
    • (2009) Veterinary Pathol , vol.1081 , pp. 46
    • Whitney, K.1    Schwartz, A.2    Oconnor, J.3    Foley, G.4    Garman, R.5
  • 21
    • 4344622306 scopus 로고    scopus 로고
    • Pathology raw data in nonclinical laboratory studies for the pharmaceutical industry: The pathologists' view
    • DOI 10.1002/qaj.278
    • Geoly F, Kerlin R.. Raw data in nonclinical laboratory studies for the pharmaceutical industry: the pathologists view. Qual Assur J. 2004 ; 8 (3). 161-166 (Pubitemid 39120751)
    • (2004) Quality Assurance Journal , vol.8 , Issue.3 , pp. 161-166
    • Geoly, F.J.1    Kerlin, R.L.2
  • 22
    • 80054796217 scopus 로고    scopus 로고
    • DC: Washington
    • PhRMA Annual Report. DC: Washington ; 2009 :
    • (2009) PhRMA Annual Report
  • 24
    • 0036188130 scopus 로고    scopus 로고
    • Strategic importance of research support through pathology
    • DOI 10.1080/01926230252824644
    • Cockerell GL, McKim JM, Vonderfecht SL. Strategic importance of research support through pathology. Toxicol Pathol. 2002 ; 30 (1). 4-7 (Pubitemid 34194553)
    • (2002) Toxicologic Pathology , vol.30 , Issue.1 , pp. 4-7
    • Cockerell, G.L.1    McKim Jr., J.M.2    Vonderfecht, S.L.3
  • 25
    • 0036189511 scopus 로고    scopus 로고
    • Practical aspects of discovery pathology
    • DOI 10.1080/01926230252824653
    • Burkhardt JE, Ryan AM, Germann PG. Practical aspects of discovery pathology. Toxicol Pathol. 2002 ; 30 (1). 8-10 (Pubitemid 34194554)
    • (2002) Toxicologic Pathology , vol.30 , Issue.1 , pp. 8-10
    • Burkhardt, J.E.1    Ryan, A.M.2    Germann, P.-G.3
  • 27
    • 0029041760 scopus 로고
    • A promising animal model of Alzheimers disease
    • Tanzi RE. A promising animal model of Alzheimers disease. N Engl J Med. 1995 ; 332 (22). 1512-1513
    • (1995) N Engl J Med , vol.332 , Issue.22 , pp. 1512-1513
    • Tanzi, R.E.1
  • 28
    • 77952138048 scopus 로고    scopus 로고
    • Renal biomarker qualification submission: A dialog between the FDA-EMEA and predictive safety testing consortium
    • Dieterle F, Sistare F, Goodsaid F, et al. Renal biomarker qualification submission: a dialog between the FDA-EMEA and predictive safety testing consortium. Nat Biotechnol. 2010 ; 28 (5). 455-462
    • (2010) Nat Biotechnol , vol.28 , Issue.5 , pp. 455-462
    • Dieterle, F.1    Sistare, F.2    Goodsaid, F.3
  • 29
    • 34547656228 scopus 로고    scopus 로고
    • The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates
    • DOI 10.1038/nrd2378, PII NRD2378
    • Kramer JA, Sagartz JE, Morris DL. The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nat Rev Drug Discov. 2007 ; 6 (8). 636-649 (Pubitemid 47207750)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.8 , pp. 636-649
    • Kramer, J.A.1    Sagartz, J.E.2    Morris, D.L.3
  • 32
    • 80054812608 scopus 로고    scopus 로고
    • 1. 2nd ed. San Diego: Academic Press; 2002:307-326. Haschek W Rouseaux C Wallig M, ed. San Diego: Academic Press
    • Ochoa R Handbook of Toxicologic Pathology. 1. 2nd ed. San Diego: Academic Press; 2002:307-326. Haschek W Rouseaux C Wallig M, ed. San Diego: Academic Press ; 2002: 307-326.
    • (2002) Handbook of Toxicologic Pathology , pp. 307-326
    • Ochoa, R.1
  • 33
    • 0036192051 scopus 로고    scopus 로고
    • Application of genetically altered models as replacement for the lifetime mouse bioassay in pharmaceutical development
    • DOI 10.1080/01926230252824842
    • Alden C, Smith P, Morton D. Application of genetically altered models as replacement for the lifetime mouse bioassay in pharmaceutical development. Toxicol Pathol. 2002 ; 30 (1). 135-138 (Pubitemid 34194571)
    • (2002) Toxicologic Pathology , vol.30 , Issue.1 , pp. 135-138
    • Alden, C.1    Smith, P.2    Morton, D.3
  • 34
    • 80054796006 scopus 로고
    • Testing for carcinogenicity of pharmaceuticals S1B
    • Testing for carcinogenicity of pharmaceuticals S1B,. Federal Register. 1995 ; (40). 11278-11281
    • (1995) Federal Register , Issue.40 , pp. 11278-11281
  • 35
    • 0000484871 scopus 로고
    • Dose Selection for carcinogenicity studies of pharmaceuticals S1C, core guideline
    • Dose Selection for carcinogenicity studies of pharmaceuticals S1C, core guideline. Federal Register. 1995 ; 60 (40). 11278-11281
    • (1995) Federal Register , vol.60 , Issue.40 , pp. 11278-11281
  • 36
    • 80054813543 scopus 로고    scopus 로고
    • Guideline on the need for carcinogenicity studies of pharmaceuticals S1A
    • Guideline on the need for carcinogenicity studies of pharmaceuticals S1A. Federal Register. 1996 ; 8153: 61
    • (1996) Federal Register , vol.8153 , pp. 61
  • 37
    • 80054826358 scopus 로고    scopus 로고
    • Addendum to testing for carcinogenicity of pharmaceuticals S1B
    • Addendum to testing for carcinogenicity of pharmaceuticals S1B. Federal Register. 1997 ; 62 (233). 64260
    • (1997) Federal Register , vol.62 , Issue.233 , pp. 64260
  • 38
    • 80054826358 scopus 로고    scopus 로고
    • Addendum to dose selection for carcinogenicity studies of pharmaceuticals S1C, core guideline
    • Addendum to dose selection for carcinogenicity studies of pharmaceuticals S1C, core guideline. Federal Register. 1997 ; 62 (233). 64260
    • (1997) Federal Register , vol.62 , Issue.233 , pp. 64260
  • 39
    • 33847721500 scopus 로고    scopus 로고
    • The role of pathology in the identification of drug-induced hepatic toxicity
    • DOI 10.1517/17425255.2.2.241
    • Cullen JM, Miller RT. The role of pathology in the identification of drug-induced hepatic toxicity. Expert Opin Drug Metab Toxicol. 2006 ; 2 (2). 241-247 (Pubitemid 46372367)
    • (2006) Expert Opinion on Drug Metabolism and Toxicology , vol.2 , Issue.2 , pp. 241-247
    • Cullen, J.M.1    Miller, R.T.2
  • 45
    • 63949083731 scopus 로고    scopus 로고
    • Melamine nephrotoxicity: An emerging epidemic in an era of globalization
    • Bhalla V, Grimm PC, Chertow GM, Pao AC. Melamine nephrotoxicity: an emerging epidemic in an era of globalization. Kidney Int. 2009 ; 75 (8). 774-779
    • (2009) Kidney Int , vol.75 , Issue.8 , pp. 774-779
    • Bhalla, V.1    Grimm, P.C.2    Chertow, G.M.3    Pao, A.C.4
  • 46
    • 0028792631 scopus 로고
    • Urinary bladder carcinogenesis induced by melamine in F344 male rats: Correlation between carcinogenicity and urolith formation
    • Ogasawara H, Imaida K, Ishiwata H, et al. Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation. Carcinogenesis. 1995 ; 16 (11). 2773-2777
    • (1995) Carcinogenesis , vol.16 , Issue.11 , pp. 2773-2777
    • Ogasawara, H.1    Imaida, K.2    Ishiwata, H.3
  • 48
    • 54349101288 scopus 로고    scopus 로고
    • Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs
    • Dobson RL, Motlagh S, Quijano M, et al. Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs. Toxicol Sci. 2008, 106 (1). 251-262
    • (2008) Toxicol Sci , vol.106 , Issue.1 , pp. 251-262
    • Dobson, R.L.1    Motlagh, S.2    Quijano, M.3
  • 49
    • 77958163991 scopus 로고    scopus 로고
    • Comparative nephrotoxicitiy induced by melamine, cyanuric acid, or a mixture of both chemicals in either Sprague-Dawley rats or renal cell lines
    • Choi L, Kwak MY, Kwak EH, et al. Comparative nephrotoxicitiy induced by melamine, cyanuric acid, or a mixture of both chemicals in either Sprague-Dawley rats or renal cell lines. J Toxicol Environ Health A. 2010 ; 73 ((21-22)). 1407-1419
    • (2010) J Toxicol Environ Health A , vol.73 , Issue.21-22 , pp. 1407-1419
    • Choi, L.1    Kwak, M.Y.2    Kwak, E.H.3
  • 50
    • 59949093520 scopus 로고    scopus 로고
    • Melamine toxicity and the kidney
    • Hau AK, Kwan TH, Li PK. Melamine toxicity and the kidney. J Am Soc Nephrol. 2009 ; 20 (2). 245-250
    • (2009) J Am Soc Nephrol , vol.20 , Issue.2 , pp. 245-250
    • Hau, A.K.1    Kwan, T.H.2    Li, P.K.3
  • 51
    • 3142744225 scopus 로고    scopus 로고
    • Ballantyne B Marrs TC Syversen T, ed. Basingstoke: MacMillan
    • Woodward K General and Applied Toxicology. Ballantyne B Marrs TC Syversen T, ed. Basingstoke: MacMillan ; 1999: 1633-1652.
    • (1999) General and Applied Toxicology , pp. 1633-1652
    • Woodward, K.1
  • 53
    • 0037401126 scopus 로고    scopus 로고
    • Proposal for a tiered approach to developmental toxicity testing for veterinary pharmaceutical products for food-producing animals
    • DOI 10.1016/S0278-6915(02)00326-5
    • Hurtt ME, Cappon GD, Browning A. Proposal for a tiered approach to developmental toxicity testing for veterinary pharmaceutical products for food-producing animals. Food Chem Toxicol. 2003 ; 41 (5). 611-619 (Pubitemid 36349541)
    • (2003) Food and Chemical Toxicology , vol.41 , Issue.5 , pp. 611-619
    • Hurtt, M.E.1    Cappon, G.D.2    Browning, A.3
  • 54
  • 55
    • 80054795295 scopus 로고    scopus 로고
    • Woodward K, ed. Chichester, UK: Wiley-Blackwell
    • Keck G, Pineau X Veterinary Pharmacovigilance. Woodward K, ed. Chichester, UK: Wiley-Blackwell ; 2008: 55-64.
    • (2008) Veterinary Pharmacovigilance , pp. 55-64
    • Keck, G.1    Pineau, X.2
  • 56
    • 80054810017 scopus 로고    scopus 로고
    • Woodward K, ed. Chichester, UK: Wiley-Blackwell
    • Woodward K Veterinary Pharmacovigilance. Woodward K, ed. Chichester, UK: Wiley-Blackwell ; 2008: 297-345.
    • (2008) Veterinary Pharmacovigilance , pp. 297-345
    • Woodward, K.1
  • 57
    • 80054827595 scopus 로고    scopus 로고
    • Woodward K, ed. Chichester, UK: Wiley-Blackwell
    • Woodward K Veterinary Pharmacovigilance. Woodward K, ed. Chichester, UK: Wiley-Blackwell ; 2008: 1946-1345.
    • (2008) Veterinary Pharmacovigilance , pp. 1946-1345
    • Woodward, K.1
  • 58
    • 80054807913 scopus 로고    scopus 로고
    • Woodward K, ed. Chichester, UK: Wiley-Blackwell
    • Woodward K. Veterinary Pharmacovigilance. Woodward K, ed. Chichester, UK: Wiley-Blackwell ; 2008: 119-149.
    • (2008) Veterinary Pharmacovigilance , pp. 119-149
    • Woodward, K.1
  • 59
    • 80054813934 scopus 로고    scopus 로고
    • Woodward K, ed. Chichester, UK: Wiley-Blackwell
    • Woodward K Veterinary Pharmacovigilance. Woodward K, ed. Chichester, UK: Wiley-Blackwell ; 2008: 109-117.
    • (2008) Veterinary Pharmacovigilance , pp. 109-117
    • Woodward, K.1
  • 60
    • 80054825586 scopus 로고    scopus 로고
    • The Agencys Contribution to Sciences
    • The Agencys Contribution to Sciences. Medicines, Health January. 2015 ; 26: 2010
    • (2015) Medicines, Health January , vol.26 , pp. 2010
  • 61
    • 0031046253 scopus 로고    scopus 로고
    • Environmental protection agency risk assessment - Process and toxicologic pathology
    • Copley MP. Environmental Protection Agency risk assessment-process and toxicologic pathology. Toxicol Pathol. 1997 ; 25 (1). 68-71 (Pubitemid 27100561)
    • (1997) Toxicologic Pathology , vol.25 , Issue.1 , pp. 68-71
    • Copley, M.P.1
  • 62
    • 24044534002 scopus 로고    scopus 로고
    • 6th ed.McGraw-Hill Professional, New York; 2001:1141-1153. Klaassen CD, ed. New York: McGraw-Hill Professional
    • Merrill RA Casarett & Doulls Toxicology: The Basic Science of Poisons. 6 th ed.McGraw-Hill Professional, New York; 2001:1141-1153. Klaassen CD, ed. New York: McGraw-Hill Professional ; 2001: 1141-1153.
    • (2001) Casarett & Doulls Toxicology: The Basic Science of Poisons , pp. 1141-1153
    • Merrill, R.A.1
  • 65
    • 0344683235 scopus 로고    scopus 로고
    • 8th ed. The National Academies Press, Washington, DC; 2010. The National Academies Press
    • Guide for the Care and Use of Laboratory Animals. 8 th ed. The National Academies Press, Washington, DC; 2010. The National Academies Press ; 2010 :
    • (2010) Guide for the Care and Use of Laboratory Animals
  • 66
    • 80054793773 scopus 로고    scopus 로고
    • 21st ed. 21 VolPart 58, Good Laboratory Practice for Non-Clinical Laboratory Studies.
    • Administration FaD. 21 st ed. 21 VolPart 58, Good Laboratory Practice for Non-Clinical Laboratory Studies.
    • Administration FaD
  • 68
    • 0024240129 scopus 로고
    • Review of pathology data for regulatory purposes
    • Dua PN, Jackson BA. Review of pathology data for regulatory purposes. Toxicol Pathol. 1988 ; 16 (4). 443-450 (Pubitemid 19030154)
    • (1988) Toxicologic Pathology , vol.16 , Issue.4 , pp. 443-450
    • Dua, P.N.1    Jackson, B.A.2
  • 69
    • 12844253310 scopus 로고    scopus 로고
    • Confounders in interpreting pathology for safety and risk assessment
    • DOI 10.1016/j.taap.2004.06.022, PII S0041008X04003333
    • Wolf DC, Mann PC. Confounders in interpreting pathology for safety and risk assessment. Toxicol Appl Pharmacol. 2005 ; 202 (3). 302-308 (Pubitemid 40164283)
    • (2005) Toxicology and Applied Pharmacology , vol.202 , Issue.3 , pp. 302-308
    • Wolf, D.C.1    Mann, P.C.2
  • 71
    • 20944442212 scopus 로고    scopus 로고
    • STP position paper: Best practice guideline for the routine pathology evaluation of the immune system
    • 408-407
    • Haley P, Perry R, Ennulat D, et al. STP position paper: best practice guideline for the routine pathology evaluation of the immune system. Toxicol Pathol. 2005 ; 33 (3). 404 408-407
    • (2005) Toxicol Pathol , vol.33 , Issue.3 , pp. 404
    • Haley, P.1    Perry, R.2    Ennulat, D.3
  • 74
    • 31144438390 scopus 로고    scopus 로고
    • Innovation: Rescuing drug discovery: In vivo systems pathology and systems pharmacology
    • van der Greef J, McBurney RN. Innovation: rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nat Rev Drug Discov. 2005 ; 4 (12). 961-967
    • (2005) Nat Rev Drug Discov , vol.4 , Issue.12 , pp. 961-967
    • Van Der Greef, J.1    McBurney, R.N.2
  • 75
    • 24644466183 scopus 로고    scopus 로고
    • Recent developments in preclinical toxicological pathology
    • Finch JM. Recent developments in preclinical toxicological pathology. Toxicol Appl Pharmacol. 2005 ; 207 ((2 suppl)). 209-213
    • (2005) Toxicol Appl Pharmacol , vol.207 , Issue.2 SUPPL , pp. 209-213
    • Finch, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.