Practical Aspects of Discovery Pathology

Toxicologic Pathology

Volumn 30, Issue 1, 2002, Pages 8-10

  Burkhardt, John E ^a   Ryan, Anne M ^a   Germann, Paul Georg ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

AMD; Animal models; confidence in mechanism; confidence in safety; monoclonal antibodies; mouse phenotyping; rats; toxicology; VEGF

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; QUINOLONE; VASCULOTROPIN; VASCULOTROPIN ANTIBODY;

ALZHEIMER DISEASE; ANTINEOPLASTIC ACTIVITY; ARTHROPATHY; ARTICLE; CLINICAL PRACTICE; DISEASE MODEL; DRUG EFFICACY; DRUG RESEARCH; HISTOPATHOLOGY; HUMAN; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; TOXICITY TESTING; TRANSGENIC ANIMAL;

4-QUINOLONES; ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIBODIES; DISEASE MODELS, ANIMAL; ENDOTHELIAL GROWTH FACTORS; HAPLORHINI; HUMANS; LYMPHOKINES; MICE; PATHOLOGY; PHENOTYPE; RATS; RATS, INBRED BN; RESEARCH; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA;

EID: 0036189511     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230252824653     Document Type: Article

References (9)

1. Ahlijanian MK, Barrezueta NX, Williams RD, Jakowski A., Kowsz K., McCarthy S., Coskran T., Carlo A., Seymour P., Burkhardt JE, Nelson RB, McNeish JD (2000). Hyperphosphorylated tau and neurofi lament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci USA 97: 2910-2915.
2. Burkhardt JE, Eskra JD, Clemo Fas, Otterness IG (1999). Effects of nalidixic acid on hamster knee cartilage morphology and synovial fluid composition. Toxicol Pathol 27: 421-426.
3. Germann P-G., Häfner D., Hanauer G., Drommer W. (1998). J Exp Anim Sci 39: 22-33.
4. Haczku A., Moqbel R., Elwood W., Sun J., Kay AB, Barnes PJ, Chung KF, (1994). Effects of prolonged repeated exposure to ovalbumin in sensitized Brown Norway rats. Am J Respir Care Med 150: 23-27.
5. van Hillegersberg R., Hekking-Weijma JM, Wilson JH, Edixhoven-Bosdij k A., Kort WJ (1995). Adjuvant intraoperative photodynamic therapy diminishes the rate of local recurrence in a rat mammary tumour model. Br J Cancer 71: 733-737.
6. Karol MH (1994). Animal models of occupational asthma. Eur Respir J 7: 555-568.
7. Mordenti J., Cuthbertson RA, Ferrara N., Thomsen K., Berleau L., Licko V., Allen PC, Valverde CR, Meng YG, Fei DTW, Fourre KM, Ryan AM (1999). Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125 I-labeled full-length and Fab antibodies in Rhesus monkeys following intravitreal administration. Toxicol Pathol 27: 536-544.
8. Ryan AM, Eppler DB, Hagler KE, Bruner, RH, Thomford PJ, Hall RL, Shopp GM, O'Neill CA (1999). Preclinical safety evaluation of rhuMabVEGF, an antiangiogenic humanized monoclonal antibody. Toxicol Pathol 27: 78-86.
9. Schaffner J-C., Wood J., Germann P-G. (2000). Effectiveness of a VEGFinhibitor on tumor growth and histopathology in a human prostatic carcinoma model in nude mice. Pathol Res Pract 196: 398.