Effects of cyclosporin-a on rat skeletal biomechanical properties

BMC Musculoskeletal Disorders

Volumn 12, Issue , 2011, Pages

  Chen, Yixin ^a   Zheng, Xin ^a   Zou, Rui ^a   Wang, Junfei ^a  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BODY WEIGHT; BONE DENSITY; BONE STRESS; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFECT; ENERGY ABSORPTION; FEMUR NECK; FEMUR SHAFT; HISTOPATHOLOGY; LIVER NECROSIS; LUMBAR VERTEBRA; MALE; NONHUMAN; RAT; TISSUE NECROSIS; TRABECULAR BONE; YOUNG MODULUS; ANIMAL; FEMUR; MECHANICAL STRESS; METABOLISM; PHYSIOLOGY; RADIOGRAPHY; SKELETAL MUSCLE; SUBCUTANEOUS DRUG ADMINISTRATION; WEIGHT BEARING; WISTAR RAT;

ANIMALS; BIOMECHANICS; BONE DENSITY; CYCLOSPORINE; FEMUR; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, SUBCUTANEOUS; LUMBAR VERTEBRAE; MALE; MUSCLE, SKELETAL; RATS; RATS, WISTAR; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 80054821718     PISSN: None     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-12-240     Document Type: Article

References (35)

1. Post-transplantation osteoporosis. Kulak CA, Borba VZ, Kulak Junior J, Campos DJ, Shane E, Arq Bras Endocrinol Metabol 2010 54 143 149 20485902
2. Approach to the patient with transplantation-related bone loss. Ebeling PR, J Clin Endocrinol Metab 2009 94 1483 1490 10.1210/jc.2009-0205 19420272
3. Effects of three immunosuppressive regimens on vertebral bone density in renal transplant recipients: a prospective study. Aroldi A, Tarantino A, Montagnino G, Cesana B, Cocucci C, Ponticelli C, Transplantation 1997 63 380 386 10.1097/00007890-199702150-00009 9039927 (Pubitemid 27086029)
4. Cyclosporine bone remodeling effect prevents steroid osteopenia after kidney transplantation. Westeel FP, Mazouz H, Ezaitouni F, Hottelart C, Ivan C, Fardellone P, Brazier M, EL Esper L, Petit J, Achard JM, Pruna A, Fournie A, Kidney Int 2000 58 1788 1796 10.1046/j.1523-1755.2000.00341.x 11012914
5. Frequency and predictors of osteoporotic fractures after cardiac and liver transplantation: a fellow-up study. Leidig-Bruckner G, Hosch S, Dodidou P, Ritschel D, Conradt C, Klose C, Otto C, Lanqe R, Theilmann L, Zimmerman R, Pritsch M, Zieqler R, Lancet 2001 357 342 347 10.1016/S0140-6736(00)03641-2 11210996 (Pubitemid 32128540)
6. High-turnover osteoporosis is induced by cyclosporin A in rats. Wada C, Kataoka M, Seto H, Hayashi N, Kido J, Shinohara Y, Nagata T, J Bone Miner Metab 2006 24 199 205 10.1007/s00774-005-0672-x 16622732
7. Alendronate prevents cyclosporin A-induced osteopenia in the rat. Sass DA, Bowman AR, Yuan Z, Ma Y, Jee WS, Epstein S, Bone 1997 21 65 70 10.1016/S8756-3282(97)00071-9 9213009 (Pubitemid 27341740)
8. Immunosuppressant use without bone loss-implications for bone loss after transplantation. Goodman GR, Dissanayake IR, Sodam BR, Gorodetsky E, Lu J, Ma YF, Jee WS, Epstein S, J Bone Miner Res 2001 16 72 78 10.1359/jbmr.2001.16.1.72 11149492 (Pubitemid 32046190)
9. Cyclosporin A dose not affect the absolute rate of cortical bone resorption at the organ level in the growing rat. Klein L, Lemel MS, Wolfe MS, Shaffer J, Calcif Tissue Int 1994 55 295 301 10.1007/BF00310409 7820781 (Pubitemid 24292347)
10. Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation. Yeo H, Beck LH, McDonald JM, Zayzafoon M, Bone 2007 40 1502 1516 10.1016/j.bone.2007.02.017 17392048 (Pubitemid 46766648)
11. Cyclosporin-A in vivo produces severve osteopenia in the rat: effect of dose and duration of administration. Movsowitz C, Epsten S, Fallon M, Ismail F, Thomas S, Endocrinology 1988 123 2571 2577 10.1210/endo-123-5-2571 3262506
12. Transforming growth factor-beta administration modifies cyclosporine A-induced bone loss. Goodman GR, Dissanayake IR, Bowman AR, Pun S, Ma Y, Jee WS, Bryer HP, Epstein S, Bone 2001 28 583 588 10.1016/S8756-3282(01)00428-8 11425645 (Pubitemid 32577375)
13. Raloxifene analog (LY117018 HCL) ameliorates cyclosporin A-induced osteopenia in oophorectomized rats. Bowman AR, Sass DA, Marshall I, Ma YF, Liang H, Jee WS, Epstein S, J Bone Miner Res 1996 11 1191 1198 8854256 (Pubitemid 26321370)
14. Effect of the interaction of parathyroid hormone and cyclosporine a on bone mineral metabolism in the rat. Epstein S, Dissanayake IR, Goodman GR, Bowman AR, Zhou H, Ma Y, Jee WS, Calcif Tissue Int 2001 68 240 247 10.1007/s002230001167 11353952 (Pubitemid 32423111)
15. T lymphocytes play a critical role in the development of cyclosporin A-induced osteopenia. Buchinsky FJ, Ma Y, Mann GN, Rucinski B, Bryer HP, Romero DF, Jee WS, Epstein S, Endocrinology 1996 137 2278 2285 10.1210/en.137.6.2278 8641176 (Pubitemid 26155759)
16. Revival of bone strength: the bottom line. Jarvinen TLN, Sievanen H, Jokihaara J, Einhorn TA, J Bone Miner Res 2005 20 717 720 10.1359/JBMR.050211 15824843 (Pubitemid 40571627)
17. Effect of short-term cyclosporin-A on biomechanical properties of intact and fractured bone in the rat. Warren SB, Pelker RR, Friedlaender GE, J Orthop Res 1985 3 96 100 10.1002/jor.1100030112 3981300 (Pubitemid 15148026)
18. A histomorphological investigation of the effect of cyclosprin on trabecular bone of the rat mandibular condyle. Earl F, Hsieh YD, Mao TK, Shen EC, Arch Oral Biol 2001 46 1105 1110 10.1016/S0003-9969(01)00080-2 11684029 (Pubitemid 33086340)
19. Effects of orthotopic liver transplantation in inbred rats on bone biomechanical properties. Chen YX, Zheng X, Wang JF, Mao L, Ding YT, Transplant Proc 2010 42 3809 3814 10.1016/j.transproceed.2010.08.051 21094861
20. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR, J Bone Miner Res 1987 2 595 610 3455637
21. Low bone mass and severity of cholestasis affect fracture risk in patients with primary biliary cirrhosis. Guanabens N, Cerda D, Monegal A, Pons F, Caballeria L, Peris P, Pares A, Gastroenterology 2010 138 2348 2356 10.1053/j.gastro.2010.02.016 20178794
22. Impaired bone geometry after heart and heart-lung transplantation in childhood. Bechtold S, Putzker S, Birnbaum J, Schwarz HP, Netz H, Pozza RD, Transplantation 2010 90 1006 1010 20921936
23. Skeletal integrity and visceral transplantation. Resnick J, Gupta N, Wagner J, Costa G, Cruz RJ Jr, Martin L, Koritsky DA, Perera S, Matarese L, Eid K, Schuster B, Roberts M, Greenspan S, Abu-Elmaqd K, Am J Transplant 2010 10 2331 2340 10.1111/j.1600-6143.2010.03245.x 20825384
24. The immune system and bone. Pacifici R, Arch Broche Biophys 2010 503 41 53 10.1016/j.abb.2010.05.027
25. Immunosuppressant drugs and bone disease: a clinician's perspective. Epstein s, J Clin Denitom 1998 1 317 321 10.1385/JCD:1:4:317 (Pubitemid 128348653)
26. Incident hip fracture and social disadvantages in an Australian population aged 50 years or greater. Brennan SL, Henry MJ, Kotowicz MA, Nicholson GC, Zhang Y, Pasco JA, Bone 2011 48 607 610 10.1016/j.bone.2010.10.175 21040808
27. Osteoporosis and mortality. Leboime A, Confavreux CB, Mehsen N, Paccou J, David C, Roux C, Joint Bone Spine 2010 77 Suppl 2 107 112
28. Association between vertebral fracture and increased mortality in osteoporotic patients. Jalava T, Sarna S, Pylkkanen L, Mawer B, Kanis JA, Selby P, Davies M, Adams J, Francis RM, Robinson J, McCloskey E, J Bone Miner Res 2003 18 1254 1260 10.1359/jbmr.2003.18.7.1254 12854835 (Pubitemid 37294918)
29. Mortality following hip fracture: trends and geographical variations over the last 40 years. Haleem S, Lutchman L, Mayahi R, Grice JE, Parker MJ, Injury 2008 39 1157 1163 10.1016/j.injury.2008.03.022 18653186
30. The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 one bone mineral metabolism in vivo. Cvetkovic M, Mann GN, Romero DF, Liang XG, Ma Y, Jee WS, Epstein S, Transplantation 1994 57 1231 1237 10.1097/00007890-199404270-00016 7513912 (Pubitemid 24139647)
31. The immune system and bone. Archives of Biochemistry and Biophysics. Pacific R, 2010 503 41 53
32. The bone and the kidney. Archives of Biochemistry and Biophysics. Mazzarerro S, Pasquali M, Pirro G, Rotondi S, Tartaglione L, 2010 503 95 102
33. Bone quality in animal models of osteoporosis. Grynpas MD, Chachra D, Lundon K, Drug Development Research 2000 49 146 158 10.1002/(SICI)1098- 2299(200003)49:3<146::AID-DDR5>3.0.CO;2-Y (Pubitemid 30324631)
34. Different effects of cyclosporin A on bone remodeling in young and adult rats. Del Pozo E, Lippuner K, Ruch W, Casez JP, Payne T, Mackenzie A, Jaeqer P, Bone 1995 16 Suppl 4 271 275
35. The influences of age on cyclosprin A-induced alterations in bone mineral metabolism in the rat in vivo. Katz I, Li M, Joffe I, Stein B, Jacobs T, Liang XG, Ke HZ, Jee W, Epstein S, J Bone Miner Res 1994 9 59 66 8154310