Raloxifene analog (LY117018 HCL) ameliorates cyclosporin A-induced osteopenia in oophorectomized rats

Journal of Bone and Mineral Research

Volumn 11, Issue 8, 1996, Pages 1191-1198

  Bowman, A R ^a   Sass, D A ^a   Marshall, I ^a   Ma, Y F ^b   Liang, H ^b   Jee, W S S ^b   Epstein, S ^a  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXY 2 (4 HYDROXYPHENYL) 3 [4 [2 (1 PYRROLIDINYL)ETHOXY]BENZOYL]BENZO[B]THIOPHENE; CALCITRIOL; CYCLOSPORIN A; ESTRADIOL; GLUCOSE; OSTEOCALCIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE TURNOVER; CONTROLLED STUDY; ESTROGEN DEFICIENCY; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOPENIA; OVARIECTOMY; RAT; TIBIA;

EID: 0029742725     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650110819     Document Type: Article

References (45)

1. Walsh CT, Zydowsky LD, McKeon FD 1992 Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T-cell signal transduction. J Biol Chem 267:13115-13118.
2. Epstein S 1996 Post-transplantation bone disease: The role of immunosuppressive agents and the skeleton. J Bone Miner Res 11(1):1-7.
3. Katz IA, Epstein S 1992 Posttransplantation bone disease. J Bone Miner Res 7:123-126.
4. Julian BA, Laskow DA, Dubovsky J, Dubovsky EV, Curtis JJ, Quarles LD 1991 Rapid loss of vertebral mineral density after renal transplantation. New Engl J Med 325:544-550.
5. Aubia J, Masramon J, Serrano S, Lloveras J, Marinoso LL 1988 Bone histology in renal transplant patients receiving cyclosporin. Lancet 1:1048-1049.
6. Rich GM, Mudge GH, Laffel GL, LeBoff MS 1992 Cyclosporine A and prednisone-associated osteoporosis in heart transplant recipients. J Heart Lung Transplant 11:950-958.
7. Shane E, Rivas MDC, Silverberg SJ, Kim TS, Staron RB, Bilezikian JP 1993 Osteoporosis after cardiac transplantation. Am J Med 94:257-264.
8. Sambrook PN, Kelly PJ, Fontana D, et al. 1994 Mechanisms of rapid bone loss following cardiac transplantation. Osteoporosis Int 4:273-276.
9. McDonald JA, Dunstan CR, Dilworth P, et al. 1991 Bone loss after liver transplantation. Hepatology 14:613-619.
10. Keown PA, Stiller CR 1987 Cyclosporine: A double-edged sword. Hosp Prac 22:207-220.
11. Kahan BD 1989 Cyclosporine. New Engl J Med 321:1725-1738.
12. Stewart PJ, Green OC, Stern PH 1986 Cyclosporin A inhibits calcemic hormone-induced bone resorption in vitro. J Bone Miner Res 1:285.
13. Stewart PJ, Stern PH 1989 Cyclosporines: Correlation of immunosuppressive activity and inhibition of bone resorption. Calcif Tissue Int 45:222-226.
14. Klaushofer K, Hoffmann O, Stewart PJ, et al. 1987 Cyclosporin A inhibits bone resorption in cultured neonatal mouse calvaria. J Pharmacol Exp Ther 243(2):584-590.
15. Movsowitz C, Epstein S, Ismail F, Fallon M, Thomas S 1989 Cyclosporin A in the oophorectomized rat: Unexpected severe bone resorption. J Bone Miner Res 4:393-398.
16. Joffe I, Katz I, Jacobs T, et al. 1992 17β-estradiol prevents osteopenia in the oophorectomized rat treated with cyclosporin-A. Endocrinology 130:1578-1586.
17. Judd HL, Meldrum DR, Deftos LJ, Henderson BE 1983 Estrogen replacement therapy: Indications and complications. Ann Int Med 98:195-205.
18. Sheil AGR, Disney APS, Mathew TH, Amiss N 1993 De novo malignancy emerges as a major cause of morbidity and late failure in renal transplantation. Trans Proc 25(1):1383-1384.
19. Penn I 1993 Effect of immunosuppression on preexisting cancers. Trans Proc 25(1):1380-1382.
20. Evans G, Bryant H, Sato M, Turner RT 1993 Raloxifene is a tissue specific estrogen agonist. J Bone Miner Res 8:S134.
21. Jones CD, Suarez T, Massey EH, Black LJ, Tinsley FC 1979 Synthesis and anti-estrogenic activity of [3,4-dihydro-2-(4-methoxyphenyl)-1-napthalenyl][4-[2-pyrrolidinyl) ethoxy] methanone, methanesulphonic acid salt. J Med Chem 22:962-966.
22. Jordan VC, Phelps E, Lindgren JU 1987 Effects of anti-estrogens on bone in castrated and intact female rats. Breast Cancer Res Treat 10:31-35.
23. Sato M, McClintock C, Kim J, et al. 1994 Dual-energy x-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats. J Bone Miner Res 9(5):715-724.
24. Evans G, Bryant HU, Magee D, Sato M, Turner RT 1994 The effects of raloxifene on tibia histomorphometry in ovariectomized rats. Endocrinology 134(5):2283-2238.
25. Turner CH, Sato M, Bryant HU 1994 Raloxifene preserves bone strength and bone mass in ovariectomized rats. Endocrinology 135(5):2001-2005.
26. Black LJ, Sato M, Rowley ER, et al. 1994 Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized ras. J Clin Invest 93:63-69.
27. Stepkowski SM, Kahan BD 1993 Synergistic activity of the triple combination: Cyclosporine, rapamycin, and brequinar. Trans Proc 25(3)(Suppl 2):29-31.
28. Padberg WM, Lord RH, Arenda D, Tilney NL, Kupiec-Weglinski JW 1988 Synergistic immunosuppressive effect of subtherapeutic doses of cyclosporin A on immunologic enhancement in rat recipients of cardiac allografts. Trans Proc XX(3)(Suppl 3):1053-1056.
29. Mason J 1992 Cyclosporins past, present, and future. Trans Proc 24(4)(Suppl 2)(August):61-63.
30. European mycophenolate mofetil cooperative study group 1995 Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 345:1321-1325.
31. Sells RA, Chandrasekhar P, Aikawa A, et al. 1994 First-line cyclosporin A monotherapy in cadaveric renal transplantation. Trans Proc 26(5):2499-2500.
32. Movsowitz C, Epstein S, Fallon M, Ismail F, Thomas S 1988 Cyclosporin A in vivo produces severe osteopenia in the rat: Effect of dose and duration of administration. Endocrinology 123:2571-2577.
33. Price PA, Parthemore JG, Deftos LJ 1980 New biochemical marker for bone metabolism: Measurement by radioimmunoassay of bone gla protein in the plasme of normal subjects and patients with bone disease. J Clin Invest 66:878.
34. Jee WSS, Inoue J, Jee KW, Haba T 1983 Histomorphometric assay of the growing long bone. In: Takahashi H (ed.) Handbook of Bone Morphology. Nishimura Co., Ltd., Niigata City, Japan, 101-122.
35. Parfitt AM, Drezner MK, Glorieux FH, et al. 1987 Bone histomorphometry: Standardization of nomenclature, symbols and units. Report of the ASBMR Histomorphometry Committee. J Bone Miner Res 2:595-610.
36. Kalu DN, Liu CC, Hardin RR, Hollis BW 1989 The aged rat model of ovarian hormone deficiency bone loss. Endocrinology 124:7-16.
37. Wronski TJ, Yen CF 1991 The ovariectomized rat as an animal model for postmenopausal bone loss. Cells Mater 81:69-74.
38. Kalu DN 1991 The ovariectomized rat model of post-menopausal bone loss. Bone Miner 15:175-192.
39. Barengolts EI, Gajardo HF, Rosol TJ, et al. 1990 Effects of Progesterone on Postovariectomy Bone Loss in Aged Rats. J Bone Miner Res 5:1143-1147.
40. Bryant HU, Black LJ, Rowley ER, Sato M, Cullinan GJ 1995 Medroxyprogesterone augments the bone effects of estrogen or raloxifene in the ovariectomized rat. Program of the 77th Annual Meeting of the Endocrine Society, Washington, DC, U.S.A., p. 596 (abstract).
41. Ismail F, Epstein S, Fallon MD, Thomas SB, Reinhardt TA 1988 Serum bone gla protein and the vitamin D endocrine system in the oophorectomized rat. Endocrinology 122:624-630.
42. Wronski TJ Dann LM, Scott KS, Cintron M 1989 Long term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int 45:360-366.
43. Wronski TJ, Schenck PA, Cintron M, Walsh CC 1987 Effect of body weight on osteopenia in ovariectomized rats. Calcif Tissue Int 40:155-159.
44. Kalu DN, et al. 1984 Evaluation of the pathogenesis of skeletal changes in ovariectomized rats. Endocrinology 115(2):507-512.
45. 3 in the rat and mouse. Endocrinology 128:1369-1373.