Low Bone Mass and Severity of Cholestasis Affect Fracture Risk in Patients With Primary Biliary Cirrhosis

Gastroenterology

Volumn 138, Issue 7, 2010, Pages 2348-2356

  Guañabens, Núria ^a,b   Cerdá, Dacia ^a   Monegal, Ana ^a   Pons, Francesca ^a   Caballería, Llorenç ^a,b   Peris, Pilar ^a,b   Parés, Albert ^a,b  

^a HOSPITAL CLÍNIC   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Bone Mineral Density; Metabolic Bone Disease; Osteopenia; Osteoporosis

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE DENSITOMETRY; BONE MASS; CHOLESTASIS; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; FEMALE; FEMUR NECK; FRACTURE; HISTOPATHOLOGY; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MENOPAUSE; OSTEOPENIA; OSTEOPOROSIS; PREVALENCE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; VERTEBRA FRACTURE;

EID: 77952883232     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.02.016     Document Type: Article

References (34)

1. Parés A., and Guañabens N. Treatment of bone disorders in liver disease. J Hepatol 45 (2006) 445-453
2. Guañabens N., Parés A., Mariñoso L., et al. Factors influencing the development of metabolic bone disease in primary biliary cirrhosis. Am J Gastroenterol 85 (1990) 1356-1362
3. Zein C.O., Jorgensen R.A., Clarke B., et al. Alendronate improves bone mineral density in primary biliary cirrhosis: a randomized placebo-contolled trial. Hepatology 42 (2005) 762-771
4. Newton J., Francis R., Prince M., et al. Osteoporosis in primary biliary cirrhosis revisited. Gut 49 (2001) 282-287
5. Guañabens N., Parés A., Ros I., et al. Severity of cholestasis and advanced histological stage but not menopausal status are the major risk factors for osteoporosis in primary biliary cirrhosis. J Hepatol 42 (2005) 573-577
6. Boulton-Jones J.R., Fenn R.M.F., West J., et al. Fracture risk of women with primary biliary cirrhosis: no increase compared with general population controls. Aliment Pharmacol Ther 20 (2004) 551-557
7. Solayman-Dodaran M., Card T.R., Aithal G.P., et al. Fracture risk in people with primary biliary cirrhosis: a population-based cohort study. Gastroenterology 131 (2006) 1752-1757
8. Johnell O., Kanis J.A., Oden A., et al. Predictive value of BMD for hip and other fractures. J Bone Miner Res 20 (2005) 1185-1194
9. Brown J.P., and Fortier M. Canadian Consensus Conference on Osteoporosis, 2006 Update. JOGC 172 (2006) S95-S112
10. Cheung A.M., and Detsky A.S. Osteoporosis and fractures. Missing the bridge?. JAMA 299 (2008) 1468-1470
11. Garnero P., and Delmas P.D. Contribution of bone mineral density and bone turnover markers to the estimation of risk of osteoporotic fracture in postmenopausal women. Musculoskel Neuron Interact 4 (2004) 50-63
12. Roux C., Briot K., Horlait S., et al. Assessment of non-vertebral fracture risk in postmenopausal women. Ann Rheum Dis 66 (2007) 931-935
13. Ludwig J., Dickson E.R., and McDonald S.A. Staging of chronic non-suppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchows Arch A Path Anat Histol 379 (1978) 103-110
14. World Health Organization Study Group. assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO technical report series 843 (1994), WHO, Geneva 2-25
15. Diaz Curiel M., Garcia J.J., Carrasco J.L., et al. Prevalencia de osteoporosis determinada por densitometría en la población española. Med Clin (Barc) 116 (2001) 86-88
16. Jonhell O., and Kanis J. Epidemiology of osteoporotic fractures. Osteoporos Int 16 Suppl 2 (2005) S3-S7
17. Harvey N., Dennison E., and Cooper C. Epidemiology of osteoporotic fractures. In: Rosen C.J. (Ed). Primer on the metabolic bone diseases and disorders of mineral metabolism. 7th ed. (2006), American Society for Bone and Mineral Research, Washington, DC 198-203
18. Siris E., Miller P.D., Barrett-Connor E., et al. Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women. Results from the National Osteoporosis Risk Assessment. JAMA 286 (2001) 2815-2822
19. Pereira S.P., Bray G.P., Pitt P.I., et al. Non-invasive assessment of bone density in primary biliary cirrhosis. Eur J Gastroenterol Hepatol 11 (1999) 323-328
20. Bagur A., Mautalen C., Findor J., et al. Risk factors for the development of vertebral and total skeleton osteoporosis in patients with primary biliary cirrhosis. Calcif Tissue Int 63 (1998) 385-390
21. Menon K.V.N., Angulo P., Weston S., et al. Bone disease in primary biliary cirrhosis. J Hepatol 35 (2001) 316-323
22. Guichelar M.M.J., Malinchoc M., Sibonga J., et al. Bone metabolism in advanced cholestatic liver disease: analysis by bone histomorphometry. Hepatology 36 (2002) 895-903
23. Delmas P.D., Marin F., Marcus R., et al. Beyond hip: importance of other nonspinal fractures. Am J Med 120 (2007) 381-387
24. Hodgson S.F., Dickson E.R., Wahner H.W., et al. Bone loss and reduced osteoblast function in primary biliary cirrhosis. Ann Intern Med 103 (1985) 855-860
25. Hodgson S.F., Dickson E.R., Eastell R., et al. Rates of cancellous bone remodeling and turnover in osteopenia associated with primary biliary cirrhosis. Bone 14 (1993) 819-827
26. Guichelaar M.M.J., Malinchoc M., Sibonga J.D., et al. Bone histomorphometric changes after liver transplantation for chronic cholestatic liver disease. J Bone Miner Res 18 (2003) 2190-2199
27. Ackerman Z., Weinreb M., Amir G., et al. Bone mineral metabolism and histomorphometry in rats with cholestatic liver disease. Liver 22 (2002) 166-172
28. Smith D.L.H., Shire N.J., Watts N.B., et al. Hyperbilirubinemia is not a major contributing factor to altered bone mineral density in patients with chronic liver disease. J Clin Densitom 9 (2006) 105-113
29. Janes C.H., Dickson E.R., Okazaki R., et al. Role of hyperbilirubinemia in the impairment of osteoblast proliferation associated with cholestatic jaundice. J Clin Invest 95 (1995) 2581-2586
30. Ruiz-Gaspá S., Enjuanes A., Guañabens N., et al. Lithocholic acid down-regulates vitamin D effects in human osteoblasts. Eur J Clin Invest 40 (2010) 34-35
31. Ruiz-Gaspà S., Martinez-Ferrer A., Enjuanes A., et al. High bilirubin reduces cell survival and differentiation of primary human osteoblasts. Is this effect applicable to the serum of chronic cholestatic patients?. J Bone Miner Res 24 (Suppl 1). http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx?aid=a928 a897-3e9d-4dea-a390-433c532b7802 Accessed September 17, 2009
32. Kawelke N., Bentmann A., Hackl N., et al. Isoform of fibronectin mediates bone loss in patients with primary biliary cirrhosis by suppressing bone formation. J Bone Miner Res 23 (2008) 1278-1286
33. Olivier B.J., Schoenmaker T., Mebius R.E., et al. Increased osteoclast formation and activity by peripheral blood mononuclear cells in chronic liver disease patients with osteopenia. Hepatology 47 (2008) 259-267
34. Collier J.D., Ninkovic M., and Compston J.E. Guidelines on the management of osteoporosis associated with chronic liver disease. Gut 50 Suppl 1 (2002) 1-19