mTHPC-based photodynamic therapy induction of autophagy and apoptosis in cultured cells in relation to mitochondria and endoplasmic reticulum stress

International Journal of Oncology

Volumn 39, Issue 6, 2011, Pages 1537-1543

  François, Aurélie ^a   Marchal, Sophie ^a   Guillemin, François ^a   Bezdetnaya, Lina ^a  

^a CENTRE DE RECHERCHE EN AUTOMATIQUE DE NANCY   (France)

Author keywords

Apoptosis; Autophagy; Caspases; ER oxidative stress; mTHPC; Photodynamic therapy

Indexed keywords

CASPASE 7; CASPASE 9; CASPASE INHIBITOR; GLUCOSE REGULATED PROTEIN 78; TETRAKIS(3 HYDROXYPHENYL)CHLORIN; UNCLASSIFIED DRUG; WORTMANNIN; Z VAD FMK;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MITOCHONDRION; OXIDATIVE STRESS; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

AMINO ACID CHLOROMETHYL KETONES; ANDROSTADIENES; APOPTOSIS; AUTOPHAGY; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMANS; KINETICS; MESOPORPHYRINS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; OXIDATIVE STRESS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE INHIBITORS;

EID: 80054814022     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1174     Document Type: Article

References (42)

1. Dougherty TJ: An update on photodynamic therapy applications. J Clin Laser Med Surg 20: 3-7, 2002.
2. Whitacre CM, Satoh TH, Xue L, Gordon NH and Oleinick NL: Photodynamic therapy of human breast cancer xenografts lacking caspase-3. Cancer Lett 179: 43-49, 2002. (Pubitemid 34195652)
3. Oleinick NL, Morris RL and Belichenko I: The role of apoptosis in response to photodynamic therapy: what, where, why, and how. Photochem Photobiol Sci 1: 1-21, 2002. (Pubitemid 37069701)
4. Agostinis P, Buytaert E, Breyssens H and Hendrickx N: Regulatory pathways in photodynamic therapy induced apoptosis. Photochem Photobiol Sci 3: 721-729, 2004. (Pubitemid 39302970)
5. Buytaert E, Dewaele M and Agostinis P: Molecular effectors of multiple cell death pathways initiated by photodynamic therapy. Biochim Biophys Acta 1176: 86-107, 2007. (Pubitemid 47332075)
6. Andrzejak M, Price M and Kessel DH: Apoptotic and autophagic responses to photodynamic therapy in 1c1c7 murine hepatoma cells. Autophagy 7: Sep 1, 2010 (Epub ahead of print).
7. Buytaert E, Callewaert G, Hendrickx N, et al.: Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy. FASEB J 20: 756-758, 2006. (Pubitemid 46671205)
8. Kessel D, Vicente MG and Reiners JJ Jr: Initiation of apoptosis and autophagy by photodynamic therapy. Lasers Surg Med 38: 482-488, 2006.
9. Reiners JJ Jr, Agostinis P, Berg K, Oleinick NL and Kessel D: Assessing autophagy in the context of photodynamic therapy. Autophagy 6: 7-18, 2010.
10. Xue LY, Chiu SM, Azizuddin K, Joseph S and Oleinick NL: The death of human cancer cells following photodynamic therapy: apoptosis competence is necessary for Bcl-2 protection but not for induction of autophagy. Photochem Photobiol 83: 1016-1023, 2007. (Pubitemid 47438527)
11. Rosenfeldt MT and Ryan KM: The multiple roles of autophagy in cancer. Carcinogenesis: Feb 11, 2011 (Epub ahed of print).
12. Codogno P and Meijer AJ: Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 12: 1509-1518, 2005. (Pubitemid 41553987)
13. Chen F, Wang CC, Kim E and Harrison LE: Hyperthermia in combination with oxidative stress induces autophagic cell death in HT-29 colon cancer cells. Cell Biol Int 32: 715-723, 2008.
14. Chen Y, McMillan-Ward E, Kong J, Israels SJ and Gibson SB: Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ 15: 171-182, 2008. (Pubitemid 350286185)
15. Scherz-Shouval R and Elazar Z: ROS, mitochondria and the regulation of autophagy. Trends Cell Biol 17: 422-427, 2007. (Pubitemid 47499043)
16. Valencia A and Moran J: Reactive oxygen species induce different cell death mechanisms in cultured neurons. Free Radic Biol Med 36: 1112-1125, 2004. (Pubitemid 38479865)
17. Yorimitsu T, Nair U, Yang Z and Klionsky DJ: Endoplasmic reticulum stress triggers autophagy. J Biol Chem 281: 30299-30304, 2006. (Pubitemid 44537037)
18. Ferraro E and Cecconi F: Autophagic and apoptotic response to stress signals in mammalian cells. Arch Biochem Biophys 462: 210-219, 2007. (Pubitemid 46856320)
19. Kessel D and Arroyo AS: Apoptotic and autophagic responses to Bcl-2 inhibition and photodamage. Photochem Photobiol Sci 6: 1290-1295, 2007. (Pubitemid 350191106)
20. Sasnauskiene A, Kadziauskas J, Vezelyte N, Jonusiene V and Kirveliene V: Apoptosis, autophagy and cell cycle arrest following photodamage to mitochondrial interior. Apoptosis 14: 276-286, 2009.
21. Marchal S, Francois A, Dumas D, Guillemin F and Bezdetnaya L: Relationship between subcellular localisation of Foscan and caspase activation in photosensitised MCF-7 cells. Br J Cancer 96: 944-951, 2007. (Pubitemid 46452278)
22. Teiten MH, Marchal S, D'Hallewin MA, Guillemin F and Bezdetnaya L: Primary photodamage sites and mitochondrial events after Foscan photosensitization of MCF-7 human breast cancer cells. Photochem Photobiol 78: 9-14, 2003.
23. Kabeya Y, Mizushima N, Ueno T, et al.: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728, 2000.
24. Karim MR, Kanazawa T, Daigaku Y, Fujimura S, Miotto G and Kadowaki M: Cytosolic LC3 ratio as a sensitive index of macroautophagy in isolated rat hepatocytes and H4-II-E cells. Autophagy 3: 553-560, 2007. (Pubitemid 350060051)
25. Mizushima N: Methods for monitoring autophagy. Int J Biochem Cell Biol 36: 2491-2502, 2004.
26. Bampton ET, Goemans CG, Niranjan D, Mizushima N and Tolkovsky AM: The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/ lysosomes. Autophagy 1: 23-36, 2005.
27. Biederbick A, Rose S and Elsasser HP: A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles. J Cell Sci 112: 2473-2484, 1999. (Pubitemid 29401670)
28. Blommaart EF, Krause U, Schellens JP, Vreeling-Sindelarova H and Meijer AJ: The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 243: 240-246, 1997. (Pubitemid 27060408)
29. Lockshin RA and Zakeri Z: Apoptosis, autophagy, and more. Int J Biochem Cell Biol 36: 2405-2419, 2004. (Pubitemid 39119755)
30. Marchal S, Fadloun A, Maugain E, D'Hallewin MA, Guillemin F and Bezdetnaya L: Necrotic and apoptotic features of cell death in response to Foscan® photosensitization of HT29 monolayer and multicell spheroids. Biochem Pharmacol 69: 1167-1176, 2005. (Pubitemid 40417488)
31. Bressenot A, Marchal S, Bezdetnaya L, Garrier J, Guillemin F and Plenat F: Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells, spheroid, and subcutaneous xenografts of human carcinoma. J Histochem Cytochem 57: 289-300, 2009.
32. Klionsky DJ, Abeliovich H, Agostinis P, et al.: Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4: 151-175, 2008.
33. Xu Y, Kim SO, Li Y and Han J: Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem 281: 19179-19187, 2006. (Pubitemid 44035422)
34. Kessel D and Reiners JJ Jr: Apoptosis and autophagy after mitochondrial or endoplasmic reticulum photodamage. Photochem Photobiol 83: 1024-1028, 2007. (Pubitemid 47438509)
35. Reddy RK, Mao C, Baumeister P, Austin RC, Kaufman RJ and Lee AS: Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem 278: 20915-20924, 2003. (Pubitemid 36806399)
36. Lee AS: GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res 67: 3496-3499, 2007.
37. Li J, Ni M, Lee B, Barron E, Hinton DR and Lee AS: The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ 15: 1460-1471, 2008.
38. Verfaillie T, Salazar M, Velasco G and Agostinis P: Linking ER stress to autophagy: potential implications for cancer therapy. Int J Cell Biol 2010: 930509, 2010.
39. Wu YT, Tan HL, Huang Q, et al.: Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy 4: 2008.
40. Cao C, Subhawong T, Albert JM, et al.: Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res 66: 10040-10047, 2006. (Pubitemid 44672057)
41. Chiu SM, Xue LY, Usuda J, Azizuddin K and Oleinick NL: Bax is essential for mitochondrion-mediated apoptosis but not for cell death caused by photodynamic therapy. Br J Cancer 89: 1590-1597, 2003.
42. Xue LY, Chiu SM and Oleinick NL: Atg7 deficiency increases resistance of MCF-7 human breast cancer cells to photodynamic therapy. Autophagy 6: 248-255, 2011.