RGS14 at the interface of hippocampal signaling and synaptic plasticity

Trends in Pharmacological Sciences

Volumn 32, Issue 11, 2011, Pages 666-674

  Vellano, Christopher P ^a   Lee, Sarah Emerson ^a   Dudek, Serena M ^b   Hepler, John R ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RGS PROTEIN; RGS14 PROTEIN; UNCLASSIFIED DRUG;

BRAIN NERVE CELL; CELLULAR DISTRIBUTION; ENZYME PHOSPHORYLATION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPUS; HUMAN; LEARNING; LONG TERM POTENTIATION; MEMORY; MOLECULAR MODEL; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

CA1 REGION, HIPPOCAMPAL; GTP-BINDING PROTEINS; HUMANS; LEARNING; MEMORY; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONAL PLASTICITY; RGS PROTEINS; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 80054807478     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2011.07.005     Document Type: Review

References (71)

1. L. De Vries The Regulator of G protein Signaling family Annu. Rev. Pharmacol. Toxicol. 40 2000 235 271 (Pubitemid 30340681)
2. S. Hollinger, and J.R. Hepler Cellular regulation of RGS proteins: modulators and integrators of G protein signaling Pharmacol. Rev. 54 2002 527 559
3. E.M. Ross, and T.M. Wilkie GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein Signaling (RGS) and RGS-like proteins Annu. Rev. Biochem. 69 2000 795 827
4. G.B. Willars Mammalian RGS proteins: multifunctional regulators of cellular signalling Semin. Cell Dev. Biol. 17 2006 363 376 (Pubitemid 44066847)
5. A.G. Gilman G proteins: transducers of receptor-generated signals Annu. Rev. Biochem. 56 1987 615 649
6. K.L. Neitzel, and J.R. Hepler Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling Semin. Cell Dev. Biol. 17 2006 383 389 (Pubitemid 44066843)
7. B.E. Snow Molecular cloning and expression analysis of rat Rgs12 and Rgs14 Biochem. Biophys. Res. Commun. 233 1997 770 777 (Pubitemid 27217729)
8. S. Traver RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of Gαo Biochem. J. 350 2000 19 29
9. S. Hollinger RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain J. Neurochem. 79 2001 941 949 (Pubitemid 33117072)
10. H. Cho RGS14, a GTPase-activating protein for Giα, attenuates Giα- and G13α-mediated signaling pathways Mol. Pharmacol. 58 2000 569 576
11. S.E. Lee RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory Proc. Natl. Acad. Sci. U.S.A. 107 2010 16994 16998
12. G. Neves Synaptic plasticity, memory and the hippocampus: a neural network approach to causality Nat. Rev. Neurosci. 9 2008 65 75 (Pubitemid 350295694)
13. K. Nakazawa Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience Neuron 38 2003 305 315 (Pubitemid 36555655)
14. E.T. Rolls, and R.P. Kesner A computational theory of hippocampal function, and empirical tests of the theory Prog. Neurobiol. 79 2006 1 48
15. R. Lorente de No Studies on the structure of the cerebral cortex II. Continuation of the study of the ammonic system J. Psychol. Neurol. 46 1934 113 117
16. S.B. Simons Regional differences in hippocampal calcium handling provide a cellular mechanism for limiting plasticity Proc. Natl. Acad. Sci. U.S.A. 106 2009 14080 14084
17. M. Zhao Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons J. Neurosci. 27 2007 12025 12032 (Pubitemid 350072106)
18. V. Chevaleyre, and S.A. Siegelbaum Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop Neuron 66 2010 560 572
19. V.V. Pineda Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation Neuron 41 2004 153 163 (Pubitemid 38068441)
20. Z. Fu Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons J. Neurochem. 100 2007 118 131 (Pubitemid 46085843)
21. J. Ryu Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction J. Neurosci. 28 2008 8178 8188
22. Y. Zhu Rap2-JNK removes synaptic AMPA receptors during depotentiation Neuron 46 2005 905 916 (Pubitemid 40805351)
23. S.A. Kushner Modulation of presynaptic plasticity and learning by the H-ras/Extracellular Signal-Regulated Kinase/Synapsin I signaling pathway J. Neurosci. 25 2005 9721 9734 (Pubitemid 41510912)
24. M.B. Kennedy Integration of biochemical signalling in spines Nat. Rev. Neurosci. 6 2005 423 434 (Pubitemid 40774860)
25. C. Kiel Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations J. Mol. Biol. 348 2005 759 775 (Pubitemid 40515681)
26. F.-J. Shu RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways Cell. Signal. 22 2010 366 376
27. F.S. Willard Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector PLoS ONE 4 2009 e4884
28. C. Marty, and R.D. Ye Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptors Mol. Pharmacol. 78 2010 12 18
29. A.M. Conway Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase Biochem. J. 337 1999 171 177
30. G.E. Woodard Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle Mol. Cell. Biol. 30 2010 3519 3530
31. F. Alderton Tethering of the platelet-derived growth factor β receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells J. Biol. Chem. 276 2001 28578 28585 (Pubitemid 37391573)
32. C.P. Vellano G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of G protein signaling 14(RGS14):Gαi1 complex in live cells J. Biol. Chem. 2011 [Epub ahead of print], PMID: 21880739
33. R.J. Kimple RGS12 and RGS14 GoLoco motifs are Gαi interaction sites with guanine nucleotide dissociation inhibitor activity J. Biol. Chem. 276 2001 29275 29281
34. V. Mittal, and M.E. Linder The RGS14 GoLoco domain discriminates among Gαi isoforms J. Biol. Chem. 279 2004 46772 46778 (Pubitemid 39518326)
35. F.-J. Shu Selective interactions between Giα1 and Giα3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization Cell. Signal. 19 2007 163 176
36. M. Sato Accessory proteins for G proteins: partners in signaling Annu. Rev. Pharmacol. Toxicol. 46 2006 151 187 (Pubitemid 43271187)
37. F.S. Willard Return of the GDI: the GoLoco motif in cell division Annu. Rev. Biochem. 73 2004 925 951
38. K. Colombo Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos Science 300 2003 1957 1961 (Pubitemid 36734605)
39. B. Groves A specific role of AGS3 in the surface expression of plasma membrane proteins Proc. Natl. Acad. Sci. U.S.A. 104 2007 18103 18108 (Pubitemid 350210827)
40. B. Hampoelz, and J.A. Knoblich Heterotrimeric G proteins: new tricks for an old dog Cell 119 2004 453 456 (Pubitemid 39482345)
41. Reynolds Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network Genetics 169 2005 651 670 (Pubitemid 40404301)
42. N. Sans mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression Nat. Cell Biol. 7 2005 1179 1190
43. D.P. Siderovski The GoLoco motif: a Galphai/o binding motif and potential guanine-nucleotide exchange factor Trends Biochem. Sci. 24 1999 340 341
44. A. Takesono Receptor-independent activators of heterotrimeric G-protein signaling pathways J. Biol. Chem. 274 1999 33202 33205 (Pubitemid 129511615)
45. M. Ghosh Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation J. Biol. Chem. 278 2003 34747 34750 (Pubitemid 37102232)
46. M. Natochin Inhibition of GDP/GTP exchange on G alpha subunits by proteins containing G-protein regulatory motifs Biochemistry 40 2001 5322 5328 (Pubitemid 32374017)
47. Y.K. Peterson Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3 J. Biol. Chem. 275 2000 33193 33196
48. G.G. Tall, and A.G. Gilman Resistance to inhibitors of cholinesterase 8A catalyzes release of Gαi-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Gαi-GDP complexes Proc. Natl. Acad. Sci. U.S.A. 102 2005 16584 16589 (Pubitemid 41688820)
49. C.J. Thomas Ric-8A catalyzes guanine nucleotide exchange on Gαi1 bound to the GPR/GoLoco exchange inhibitor AGS3 J. Biol. Chem. 283 2008 23150 23160
50. C.P. Vellano Activation of the Regulator of G protein Signaling 14-Galphai1-GDP signaling complex is regulated by Resistance to Inhibitors of Cholinesterase-8A Biochemistry 50 2011 752 762
51. K.G. Miller RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system Neuron 27 2000 289 299
52. G.G. Tall Mammalian Ric-8A (synembryn) is a heterotrimeric Gα protein guanine nucleotide exchange factor J. Biol. Chem. 278 2003 8356 8362 (Pubitemid 36800584)
53. Garcia-Marcos GIV is a nonreceptor GEF for Gαi with a unique motif that regulates Akt signaling Proc. Natl. Acad. Sci. U.S.A. 106 2009 3178 3183
54. H. Le-Niculescu Identification and characterization of GIV, a novel Gαi/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles J. Biol. Chem. 280 2005 22012 22020 (Pubitemid 40827855)
55. C. Cao Gαi1 and Gαi3 are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway Sci. Signal. 2 2009 ra17
56. S.S. Oner Regulation of the AGS3·Gαi signaling complex by a seven-transmembrane span receptor J. Biol. Chem. 285 2010 33949 33958
57. S.S. Oner Receptor-regulated interaction of Activator of G-protein Signaling-4 and Galphai J. Biol. Chem. 285 2010 20588 20594
58. S. Hollinger, and J.R. Hepler Methods for measuring RGS protein phosphorylation by G protein-regulated kinases Methods Mol. Biol. 237 2003 205 219
59. S. Hollinger Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i Biochemistry 42 2003 811 819 (Pubitemid 36133306)
60. E.S. Lein Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional reconstruction J. Comp. Neurol. 485 2005 1 10 (Pubitemid 40488081)
61. E.S. Lein Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization J. Neurosci. 24 2004 3879 3889 (Pubitemid 38509418)
62. M. Sheng, and C.C. Hoogenraad The postsynaptic architecture of excitatory synapses: a more quantitative view Annu. Rev. Biochem. 76 2007 823 847
63. J.D. Sweatt Mitogen-activated protein kinases in synaptic plasticity and memory Curr. Opin. Neurobiol. 14 2004 311 317 (Pubitemid 38759861)
64. M. Zhao, and S.M. Dudek Vasopressin induces synaptic potentiation in hippocampal CA2 neurons. Program Number 550.7 Neuroscience Meeting Planner 2010 Society for Neuroscience
65. S.M. Dudek, and S.B. Simons A novel mechanism for caffeine-induced cognitive enhancement. Program Number 550.8 Neuroscience Meeting Planner 2010 Society for Neuroscience
66. J.J. Zhu Ras and Rap control AMPA receptor trafficking during synaptic plasticity Cell 110 2002 443 455 (Pubitemid 35232288)
67. T. Manabe Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation J. Neurosci. 20 2000 2504 2511 (Pubitemid 30220337)
68. Y.S. Lee, and A.J. Silva The molecular and cellular biology of enhanced cognition Nat. Rev. Neurosci. 10 2009 126 140
69. J.B. Blumer Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis J. Biol. Chem. 277 2002 15897 15903 (Pubitemid 34967870)
70. M.S. Bowers Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma Proc. Natl. Acad. Sci. U.S.A. 105 2008 12533 12538
71. M.S. Bowers Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking Neuron 42 2004 269 281 (Pubitemid 38501649)