The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 2, 2011, Pages 394-402

  Joshi, Chintamani N ^a   Martin, Danielle N ^a   Fox, Jonathan C ^a   Mendelev, Natalia N ^b   Brown, Trisha A ^a   Tulis, David A ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 AMINO 5 CYCLOPROPYLPYRIMIDINE 2 YL) 1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4B]PYRIDINE; BAY 4122772; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC NUCLEOTIDE; DT 2; GUANYLATE CYCLASE; GUANYLATE CYCLASE ACTIVATOR; PROTEIN KINASE; SERINE; TYROSYLGLYCYLARGINYLLYSYLLYSYLLYSLARGINYLARGINYLGLUTAMYLARGINYLARGINYLARGINYLPROLYLPROLYLLEUCYLARGINYLLYSYLLYSYLLYSYLLYSYLLYSYLHISTIDINE; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY INJURY; CELL LEVEL; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MUSCLE GROWTH; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ADMINISTRATION, TOPICAL; ANIMALS; CAROTID ARTERY INJURIES; CELL CYCLE; CELL MIGRATION ASSAYS; CELL PROLIFERATION; CELL SURVIVAL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; GROWTH INHIBITORS; GUANYLATE CYCLASE; MALE; MOLECULAR TARGETED THERAPY; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

EID: 80054788887     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.183400     Document Type: Article

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