Olfaction: The physics of how smell works?

Contemporary Physics

Volumn 52, Issue 5, 2011, Pages 385-402

  Brookes, Jennifer C ^a  

^a USA   (United States)

Author keywords

Electron transfer; Olfaction; Smell; Tunnelling; Vibrations

Indexed keywords

EID: 80054780152     PISSN: 00107514     EISSN: 13665812     Source Type: Journal    
DOI: 10.1080/00107514.2011.597565     Document Type: Review

References (52)

1. R. Bentley, The nose as a stereochemist. Enantiomers and odor, Chem. Rev. 106 (2006), pp. 4099-4112.
2. J.C. Brookes, A.P. Horsfield, and A.M. Stoneham, Odour character differences for enantiomers correlate with molecular flexibility, J. R. Soc. Interface 6 (2009), pp. 75-86.
3. L. Buck and R. Axel, Odorant receptors and the organization of the olfactory system, Cell 65 (1991), pp. 175-187.
4. C.M. Willis, S.M. Church, C.M. Guest, W.A. Cook, N. McCarthy, A.J. Bransbury, M.R.T. Church, and J.C.T. Church, Olfactory detection of human bladder cancer by dogs: proof of principle study, BMJ 329 (7468) (2004), p. 712.
5. P. Munday, D.L. Dixson, J.M. Donelson, G.P. Jones, M.S. Pratchett, G.V. Devitsina, and K.B. Doving, Ocean acidification impairs olfactory discrimination and homing ability of a marine fish, Proc. Natl. Acad. Sci. U.S.A. 106 (2009), pp. 1848-1852.
6. G. Sanz, C. Schlegel, J. Pernollet, and L. Briand, Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism, Chem. Senses 30(1) (2005), pp. 69-80.
7. B. Malnic, J. Hirono, T. Sato, and L.B. Buck, Combinatorial receptor codes for odors, Cell 96 (1999), pp. 713-723.
8. J.C. Brookes, A microscopic model of signal transduction mechanisms, Ph.D. thesis, University College London, 2008.
9. J. Amoore, The stereochemical theory of olfaction, Nature 199 (1963), pp. 912-913.
10. K. Mori and G. Shepard, Emerging principles of molecular signal processing by mitral/tufted cells in the olfactory bulb, Semin. Cell. Biol. 5 (1994), pp. 65-74.
11. C.S. Sell, On the unpredictability of odor, Angew. Chem. Int. Ed. 45 (2006), pp. 6254-6261.
12. T.S. Kuhn The Structure of Scientific Revolutions, 3rd ed., University of Chicago Press, Chicago, 1996.
13. L. Turin, A spectroscopic mechanism for primary olfactory reception, Chem. Senses 21(6) (1996), pp. 773-791.
14. R.H. Wright The Science of Smell, George Allen and Unwin, London, 1964.
15. G. Dyson, The scientific basis of odour, Chem. Ind. 57 (1938), pp. 647-651.
16. R. Wright, Odor and molecular vibrations: neural coding of olfactory information, J. Theor. Biol. 64 (1977), pp. 473-502.
17. J. Vidic, J. Grosclaude, R. Monnerie, M.A. Persuy, K. Badonnel, C. Baly, M. Caillol, L. Briand, R. Salesse, and E. Pajot-Augy, On a chip demonstration of a functional role for odorant binding protein in the preservation of olfactory receptor activity at high odorant concentration, Lab on a Chip 8(5) (2008), p. 678.
18. F.M.S. Souzade and G. Antunes, Biophysics of olfaction, Rep. Progr. Phys. 70 (2007), pp. 451-491.
19. P. Graziadei, Handbook of Sensory Physiology, Chemical Senses, Part 1, Olfaction, Vol. 4, Springer, New York, 1971.
20. L. Buck and R. Axel, A novel multi-gene family may encode odorant receptors, Cell 65 (1991), pp. 175-187.
21. H. Breer, Olactory receptors: molecular basis for recognition and discrimination of odors, Anal. Bioanal. Chem. 377 (2003), pp. 427-433.
22. D. Colquhoun, Binding, gating, affinity and efficacy: The interpretation of struture-activity relationships for agonists and of the effects of mutating receptors, Br. J. Pharmacol. 125 (1998), pp. 923-947.
23. F. Yoshii, S. Hirono, and I. Moriguchi, Relations between the odor of (R) ethyl citronellyl oxalate and its stable conformations, Quant. Struct.-Act. Relat. 13(2) (1994), pp. 144-147.
24. R.C. Araneda, A.D. Kini, and S. Firestein, The molecular receptive range of an odorant receptor, Nat. Neurosci. 3(12) (2000), pp. 1248-1255.
25. E. Tareilus, J. Noe, and H. Breer, Calcium signalling in olfactory neurons, Biochem. Biophys. Acta 1269 (1995), pp. 129-138.
26. N. Rawson and M.G. Gomez, Cell and molecular biology of human olfaction, Micros. Res. Tech. 58 (2002), pp. 142-151.
27. P.A. Sigala, D.A. Kraut, J.M.M. Caaveiro, B. Pybus, E.A. Ruben, D. Ringe, G.A. Petsko, and D. Herschlag, Testing geometrical discrimination within an enzyme active site: constrained hydrogen bonding in the ketosteroid isomerase hydrogen bonding in the ketosteroid isomerase oxyanion hole, J. Am. Chem. Soc. 130 (2008), pp. 13696-13708.
28. C. Roberts, Psychophysical tests of the vibration theory of olfaction, Chem. Senses 31 (2006), p. E 74.
29. M.I. Franco, L. Turin, A. Mershin, and E. Skoulakis, A molecular vibration-sensing component in Drosophila melanogaster olfaction, Proc. Natl. Acad. Sci. USA 108 (2011), pp. 3797-3802.
30. V. Jacquier, H. Pick, and H. Vogel, Characterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds, J. Neurochem. 97 (2006), pp. 537-544.
31. J. Lambe and R.C. Jaklevic, Molecular vibration spectra by inelastic electron tunneling, Phys. Rev. 165 (1968), pp. 821-832.
32. M. Galperin, M. Ratner, and A. Nitzan, Inelastic electron tunneling spectroscopy in molecular junctions: peaks and dips, J. Chem. Phys. 121 (2004), pp. 11965-11979.
33. L. Turin and F. Yoshii, Struture-odor relations: a modern perspective, in Handbook of Olfaction and Gustaion, R. Doty, ed., Marcel Dekker, New York, 2003.
34. A. Keller and L. Vosshall, A psychophysical test of the vibration theory of olfaction, Nat. Neurosci. 7 (2004), pp. 337-338.
35. L. Haffenden, V. Yaylagan, and J. Fortin, Investigation of vibrational theory of olfaction with variously labelled benzaldehydes, Food Chem. 73 (2001), pp. 67-72.
36. E.B. Wilson, J.C. Decius, and P.C. Cross Molecular Vibrations. The Theory of Infrared and Raman Vibrational Spectra, McGraw-Hill, New York, 1955.
37. J.W. Ochterski, Vibrational analysis in Gaussian. Available at http://www.gaussian.com/g_whitepap/vib.htm.
38. A. Szabo and N. Ostlund, Modern Quantum Chemistry: Introduction to Advanced Electronic Structure Theory, McGraw-Hill, New York, 1989.
39. J. Brookes, Science in perception: what can our sense of smell tell us about ourselves and the world around us?, Phil. Trans. R. Soc. 368 (2010), pp. 3491-3502.
40. D. Bendall (ed.), Protein Electron Transfer, Bios Scientific Publisher, Oxford, 1996.
41. D. DeVault Quantum-mechanical Tunnelling in Biological Systems, Cambridge University Press, Cambridge, 2008.
42. R. Marcus, Chemical and electrochemical electrontransfer theory, Annu. Rev. Phys. Chem. 15 (1964), pp. 155-196.
43. J.C. Brookes, F. Hartoutsiou, A.P. Horsfield, and A.M. Stoneham, Could humans recognize odor by phonon assisted tunneling?, Phys. Rev. Lett. 98 (2007), 038101.
44. K. Huang and A. Rhys, Theory of light absorption and non-radiative transitions in F-centres, Proc. R. Soc. Lond. 204 (1950), pp. 406-423.
45. A. Stoneham Theory of Defects in Solids. Electronic Structure of Defects in Insulators and Semiconductors, Oxford University Press, Oxford, 1975.
46. X. Song and R.A. Marcus, Quantum Correction for electron transfer rates. Comparison of polarizable versus nonpolarizable descriptions of solvent, J. Chem. Phys. 99(10) (1993), pp. 7768-7773.
47. J.C. Brookes, A.P. Horsfield, and A.M. Stoneham, The Physical Basis of Olfaction, submitted for publication.
48. A.M. Stoneham, Non-radiative transitions in semiconductors, Rep. Prog. Phys. 44 (1981), pp. 1251-1295.
49. N.A. Rakow and K.S. Suslick, A colorimetric sensor array for odour visualization, Nature 406(6797) (2000), pp. 710-713.
50. M. Simonsen and R. Coleman, Inelastic-tunnelling spectra of organic compounds, Phys. Rev. B 8 (1973), pp. 5875-5876.
51. P.B. Medawar, Advice to a Young Scientist, Basic Books, New York, 1981.
52. E.A. Hallem and J.R. Carlson, Coding of odors by a receptor repertoire, Cell 125(1) (2006), pp. 143-160.