Synthesis of isotopically labelled [14C]ZT-1 (Debio-9902), [d3]ZT-1 and (-)-[d3]huperzine A, a new generation of acetylcholinesterase inhibitors

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 54, Issue 11, 2011, Pages 720-730

  Leman, Loïc ^a   Kitson, Sean L ^a   Brown, Rodney T ^a   Cairns, Jana ^a   Watters, William ^a   McMordie, Austin ^a   Murrell, Victor L ^a   Marfurt, Judith ^b  

^a Almac Sciences   (United Kingdom)

^b DEBIOPHARM SA   (Switzerland)

Author keywords

( ) huperzine A; acetylcholinesterase; Alzheimer's disease; carbon 14; Debio 9902; deuterium; ZT 1

Indexed keywords

CARBON; NEURODEGENERATIVE DISEASES;

(-)-HUPERZINE A; ACETYLCHOLINESTERASE; ACETYLCHOLINESTERASE INHIBITORS; ALZHEIMERS DISEASE; CARBON 14; DEBIO-9902; HUPERZINE A; ISOTOPIC DISTRIBUTIONS; ISOTOPICALLY LABELED; ZT-1;

DEUTERIUM;

CHOLINESTERASE INHIBITOR; HUPERZINE A; MIMOPEZIL; PRODRUG; SCHIFF BASE;

ALZHEIMER DISEASE; ARTICLE; DRUG ISOLATION; DRUG SYNTHESIS; RADIOCHEMISTRY;

EID: 80054779669     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1918     Document Type: Article

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