Selectivity of 3′-O-methylponkoranol for inhibition of N- and C-terminal maltase glucoamylase and sucrase isomaltase, potential therapeutics for digestive disorders or their sequelae

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 21, 2011, Pages 6491-6494

  Eskandari, Razieh ^a   Pinto, B Mario ^a   Jones, Kyra ^b   Rose, David R ^b  

^a SIMON FRASER UNIVERSITY   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

Author keywords

3 O Methylponkoranol; Maltase glucoamylase; Selective inhibition; Sucrase isomaltase; Therapeutics of digestive disorders; Glucosidase inhibitors

Indexed keywords

3' O METHYLPONKORANOL; ALPHA GLUCOSIDASE; ENZYME INHIBITOR; SUCRASE ISOMALTASE; UNCLASSIFIED DRUG; 3'-O-METHYLPONKORANOL; AMYLOPECTIN; AMYLOSE; THIOPHENE DERIVATIVE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; GASTROINTESTINAL DISEASE; HYDROPHOBICITY; THERMODYNAMICS; CARBOHYDRATE ANALYSIS; CHEMISTRY; DRUG ANTAGONISM; HUMAN; MOLECULAR GENETICS;

ALPHA-GLUCOSIDASES; AMYLOPECTIN; AMYLOSE; CARBOHYDRATE SEQUENCE; ENZYME INHIBITORS; GASTROINTESTINAL DISEASES; HUMANS; MOLECULAR SEQUENCE DATA; SUCRASE-ISOMALTASE COMPLEX; THIOPHENES;

EID: 80054777640     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.069     Document Type: Article

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