Development of a high-affinity inhibitor of the prostaglandin transporter

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 2, 2011, Pages 633-641

  Chi, Yuling ^a   Min, Jaeki ^b   Jasmin, Jean Francois ^e   Lisanti, Michael P ^e   Chang, Young Tae ^c,d   Schuster, Victor L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d AGENCY FOR SCIENCE   (Singapore)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N [2 [2 (2 AZIDOETHOXY)ETHOXY]ETHYL] 4 [[4 [[2 [2 (2 BENZAMIDOETHOXY)ETHOXY]ETHYL]AMINO] 6 [(4 HYDROXYPHENYL)AMINO] 1,3,5 TRIAZIN 2 YL]AMINO]BENZAMIDE; ORGANIC ANION TRANSPORTER; PROSTAGLANDIN E2; PROSTAGLANDIN INHIBITOR; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; GENETIC STABILITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION;

4-AMINOBENZOIC ACID; ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CONTROL GROUPS; DINOPROSTONE; DOGS; DUCTUS ARTERIOSUS, PATENT; HIGH-THROUGHPUT SCREENING ASSAYS; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MICE; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; ORGANIC ANION TRANSPORTERS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 80054775987     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.181354     Document Type: Article

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