Polyomavirus JC reactivation and noncoding control region sequence analysis in pediatric Crohn's disease patients treated with infliximab

Journal of NeuroVirology

Volumn 17, Issue 4, 2011, Pages 303-313

  Bellizzi, Anna ^a   Anzivino, Elena ^a   Ferrari, Federica ^a   Di Nardo, Giovanni ^a   Colosimo, Maria Teresa ^a   Fioriti, Daniela ^b   Mischitelli, Monica ^a   Chiarini, Fernanda ^a   Cucchiara, Salvatore ^a   Pietropaolo, Valeria ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^c TEMPLE UNIVERSITY   (United States)

Author keywords

Crohn's disease; Human polyomavirus JC; Infliximab; Noncoding control region; PML; Spi B

Indexed keywords

INFLIXIMAB;

ADOLESCENT; ARTICLE; BINDING SITE; CLINICAL ARTICLE; COLON; CONTROLLED STUDY; CROHN DISEASE; DISEASE SEVERITY; FEMALE; FOLLOW UP; GENE DELETION; GENE MUTATION; GENETIC REASSORTMENT; HUMAN; HUMAN TISSUE; ILEUM; INTESTINE BIOPSY; MALE; NONCODING CONTROL REGION; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; POLYOMA VIRUS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECTUM; SEQUENCE ANALYSIS; TREATMENT DURATION; URINALYSIS; VIREMIA; VIRUS DETECTION; VIRUS GENOME; VIRUS LOAD; VIRUS REACTIVATION; VIRUS VIRULENCE;

ADOLESCENT; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; BINDING SITES; CASE-CONTROL STUDIES; CHILD; COHORT STUDIES; CROHN DISEASE; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; JC VIRUS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; MALE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; VIRUS ACTIVATION;

JC POLYOMAVIRUS;

EID: 80054767987     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-011-0036-3     Document Type: Article

References (44)

1. Agostini HT, Ryschkewitsch CF, Stoner GL (1996) Genotype profile of human polyomavirus JC excreted in urine of immunocompetent individuals. J Clin Microbiol 34:159-164 (Pubitemid 126506913)
2. Agostini HT, Deckhut A, Jobes DV, Girones R, Schlunck G, Prost MG, Frias C, Pérez-Trallero E, Ryschkewitsch CF, Stoner GL (2001) Genotypes of JC virus in East, Central and Southwest Europe. J Gen Virol 82:1221-1331 (Pubitemid 32454622)
3. Ault GS, Stoner GL (1993) Human polyomavirus JC promoter/enhancer rearrangement patterns from progressive multifocal leukoencephalopathy brain are unique derivatives of a single archetypal structure. J Gen Virol 74:1499-1507 (Pubitemid 23243159)
4. Bellizzi A, Barucca V, Fioriti D, Colosimo MT, Mischitelli M, Anzivino E, Chiarini F, Pietropaolo V (2010) Early years of biological agents therapy in Crohn's disease and risk of the human polyomavirus JC reactivation. J Cell Physiol 224:316-326
5. Berger JR (2007) Progressive multifocal leukoencephalopathy. Handb Clin Neurol 85:169-183
6. Clifford DB, De Luca A, Simpson DM, Arendt G, Giovannoni G, Nath A (2010) Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol 9:438-446
7. Comerford LW, Bickston SJ (2004) Treatment of luminal and fistulizing Crohn's disease with infliximab. Gastroenterol Clin North Am 3:387-406 (Pubitemid 38737278)
8. Costa C, Bergallo M, Sidoti F, Astegiano S, Terlizzi ME, Mazzucco G, Segoloni GP, Cavallo R (2009) Polyomaviruses BK-And JC-DNA quantitation in kidney allograft biopsies. J Clin Virol 44:20-23
9. Delbue S, Branchetti E, Boldorini R, Vago L, Zerbi P, Veggiani C, Tremolada S, Ferrante P (2008) Presence and expression of JCV early gene large T Antigen in the brains of immunocopromised and immunocompetent individuals. J Med Virol 80:2147-2152
10. Flaegstad T, Sundsfjord A, Arthur RR, Pedersen M, Traavik T, Subramani S (1991) Amplification and sequencing of the control regions of BK and JC virus from human urine by polymerase chain reaction. Virology 180:553-560
11. Frenz MB, Dunckley P, Camporota L, Jewell DP, Travis SP (2005) Comparison between prospective and retrospective evaluation of Crohn's disease activity index. Am J Gastroenterol 100:1117-1120 (Pubitemid 40769050)
12. Frisque RJ (1983) Nucleotide sequence of the region encompassing the JC virus origin of DNA replication. J Virol 46:170-176 (Pubitemid 13161256)
13. Frisque RJ, Bream GL, Cannella MT (1984) Human polyomavirus JC virus genome. J Virol 51:458-469 (Pubitemid 14091437)
14. Garrett-Sinha LA, Su GH, Rao S, Kabak S, Hao Z, Clark MR, Simon MC (1999) PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction. Immunity 10:399-408 (Pubitemid 29205476)
15. Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ (2010) The safety and side effects of monoclonal antibodies. Nat Rev Drug Discov 9:325-338
16. Khalili K, Safak M, Del Valle L, White MK (2008) JC virus molecular biology and the human demyelinating disease, progressive multifocal leukoencephalopathy. In: Shoshkes Reiss C (ed) Neurotropic virus infections. Cambridge University Press, Cambridge, UK, pp 190-211
17. Kleinschmidt-DeMasters BK, Tyler KL (2005) Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon β-1a for multiple sclerosis. N Engl J Med 353:369-374 (Pubitemid 41132341)
18. Knight DM, Trinh H, Le J, Siegel S, Shealy D, McDonough M, Scallon B, Moore MA, Vilcek J, Daddona P (1993) Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol 30:1443-1453
19. Kumar D, Bouldin TW, Berger RG (2010) A case of progressive multifocal leukoencephalopathy in a patient treated with infliximab. Arthritis Rheum 62:3191-3195
20. Kwok S, Higuchi R (1989) Avoiding false positive with PCR. Nature 339:232-238
21. Langer-Gould A, Atlas SW, Green AJ, Bollen AW, Pelletier D (2005) Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 353:375-381 (Pubitemid 41132342)
22. Lavagna A, Bergallo M, Daperno M, Sostegni R, Costa C, Leto R, Crocellà L, Molinaro G, Rocca R, Cavallo R, Pera A (2007) Infliximab and the risk of latent viruses reactivation in active Crohn's disease. Inflamm Bowel Dis 13:896-902 (Pubitemid 47203868)
23. Lindberg RL, Achtnichts L, Hoffmann F, Kuhle J, Kappos L (2008) Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients. J Neuroimmunol 194:153-164
24. Major EO (2009) Reemergence of PML in natalizumab-treated patients: new cases, same concerns. N Engl J Med 361:1041-1043
25. Major EO (2010) Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies. Annu Rev Med 61:35-47
26. Markowitz RB, Thompson HC, Mueller JF, Cohen JA, Dynan WS (1993) Incidence of BK virus and JC virus viruria in human immunodeficiency virus-infected and uninfected subjects. J Infect Dis 167:13-20 (Pubitemid 23002831)
27. Marshall LJ, Major EO (2010) Molecular regulation of JC virus tropism: insights into potential therapeutic targets for progressive multifocal leukoencephalopathy. J Neuroimmune Pharmacol 5:404-417
28. Marshall LJ, Dunham L, Major EO (2010) Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activity. J Gen Virol 91:3042-3052
29. Mayer L (2010) Evolving paradigms in the pathogenesis of IBD. J Gastroenterol 45:9-16
30. Mischitelli M, Fioriti D, Videtta M, Degener AM, Antinori A, Cinque P, Giordano A, Pietropaolo V (2005) Investigation on the role of cell transcriptional factor Sp1 and HIV-1 TAT protein in PML onset or development. J Cell Physiol 204:913-918 (Pubitemid 41099277)
31. Mischitelli M, Fioriti D, Anzivino E, Bellizzi A, Barucca V, Boldorini R, Miglio U, Sica S, Sorà F, De Matteis S, Chiarini F, Pietropaolo V (2010) Viral infection in bone marrow transplants: is JC virus involved? J Med Virol 82:138-145
32. Pietropaolo V, Videtta M, Fioriti D, Mischitelli M, Arancio A, Orsi N, Degener AM (2003) Rearrangement patterns of JC virus noncoding control region from different biological samples. J Neurovirol 9:603-611 (Pubitemid 37536716)
33. Present DH, Rutgeerts P, Targan S, Hanauer SB, Mayer L, van Hogezand RA, Podolsky DK, Sands BE, Braakman T, DeWoody KL, Schaible TF, van Deventer SJ (1999) Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 340:1398-1405 (Pubitemid 29205403)
34. Randhawa P, Baksh F, Aoki N, Tschirhart D, Finkelstein S (2001) JC virus infection in allograft kidneys: analysis by polymerase chain reaction and immunohistochemistry. Transplantation 71:1300-1303
35. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GTAN (1985) Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350-1354 (Pubitemid 16105164)
36. Sandborn WJ (2001) Transcending conventional therapies: the role of biologic and other novel therapies. Inflamm Bowel Dis 1:9-16
37. Sandborn WJ, Targan SR (2002) Biologic therapy of inflammatory bowel disease. Gastroenterology 122:1592-1608 (Pubitemid 34533555)
38. Selgrad M, De Giorgio R, Fini L, Cogliandro RF, Williams S, Stanghellini V, Barbara G, Tonini M, Corinaldesi R, Genta RM, Domiati-Saad R, Meyer R, Goel A, Boland CR, Ricciardiello L (2009) JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction. Gut 58:25-32
39. Su GH, Ip HS, Cobb BS, Lu MM, Chen HM, Simon MC (1996) The Ets protein Spi-B is expressed exclusively in B cells and T cells during development. J Exp Med 184:203-214 (Pubitemid 26247230)
40. Tan CS, Dezube BJ, Bhargava P, Autissier P, Wuthrich C, Miller J, Koralnik IJ (2009) Detection of JC virus DNA and proteins in the bone marrow of HIV-positive and HIV-negative patients: implications for viral latency and neurotropic transformation. J Infect Dis 199:881-888
41. ® (2010) Prescribing Program. In: Tysabri (Natalizumab). Available via DIALOG. http://www.tysabri.com/. Accessed 10 Jan 2011
42. Van Assche G, Van Ranst M, Sciot R, Dubois B, Vermeire S, Noman M, Verbeeck J, Geboes K, Robberecht W, Rutgeerts P (2005) Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 353:362-368 (Pubitemid 41132340)
43. Verbeeck J, Van Assche G, Ryding J, Wollants E, Rans K, Vermeire S, Pourkarim MR, Noman M, Dillner J, Van Ranst M, Rutgeerts P (2008) JC viral loads in patients with Crohn's disease treated with immunosuppression: can we screen for elevated risk of progressive multifocal leukoencephalopathy? Gut 57:1393-1397
44. Yogo Y, Kitamura T, Sugimoto C, Ueki T, Aso Y, Hara K, Taguchi F (1990) Isolation of a possible archetypal JC virus DNA sequence from non immuno-compromised individuals. J Virol 64:3139-3143 (Pubitemid 20171319)