Progressive multifocal leukoencephalopathy

Handbook of Clinical Neurology

Volumn 85, Issue , 2007, Pages 169-183

  Berger, Joseph R ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 67349141018     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0072-9752(07)85013-5     Document Type: Review

References (165)

1. Ahmed S., Rappaport J., Tada H., et al. A nuclear protein derived from brain cells stimulates transcription of the human neurotropic virus promoter, JCVE, in vitro. J Biol Chem 265 23 (1990) 13899-13905
2. Aksamit A., and Proper J. JC virus replicates in primary adult astrocytes in culture. Ann Neurol 24 (1988) 471
3. Albrecht H., Hoffmann C., Degen O., et al. Highly active antiretroviral therapy significantly improves the prognosis of patients with HIV-associated progressive multifocal leukoencephalopathy. AIDS 12 10 (1998) 1149-1154
4. Amemiya K., Traub R., Durham L., et al. Interaction of a nuclear factor-1-like protein with the regulatory region of the human polyomavirus JC virus. J Biol Chem 264 12 (1989) 7025-7032
5. Amemiya K., Traub R., Durham L., et al. Adjacent nuclear factor-1 and activator protein binding sites in the enhancer of the neurotropic JC virus. A common characteristic of many brain-specific genes. J Biol Chem 267 20 (1992) 14204-14211
6. Andrei G., Snoeck R., Vandeputte M., et al. Activities of various compounds against murine and primate polyomaviruses. Antimicrob Agents Chemother 41 3 (1997) 587-593
7. Antinori A., Ammassari A., Giancola M.L., et al. Epidemiology and prognosis of AIDS-associated progressive multifocal leukoencephalopathy in the HAART era. J Neurovirol 7 4 (2001) 323-328
8. Antinori A., Cingolani A., Lorenzini P., et al. Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy: data from the Italian Registry Investigative Neuro AIDS (IRINA). J Neurovirol 9 Suppl 1 (2003) 47-53
9. Arbusow V., Strupp M., Pfister H.W., et al. Contrast enhancement in progressive multifocal leukoencephalopathy: a predictive factor for long-term survival? [letter]. J Neurol 247 4 (2000) 306-308
10. Arthur R.R., Dagostin S., Shah K.V., et al. Detection of BK virus and JC virus in urine and brain tissue by the polymerase chain reaction. J Clin Microbiol 27 6 (1989) 1174-1179
11. Astrom K., Mancall E., Richardson E.P., et al. Progressive multifocal leukoencephalopathy. Brain 81 1 (1958) 93-127
12. Bacellar H., Munoz A., Miller E.N., et al. Temporal trends in the incidence of HIV-1-related neurologic diseases: multicenter AIDS Cohort Study, 1985-1992. Neurology 44 10 (1994) 1892-1900
13. Baril L., Jouan M., Agher R., et al. Impact of highly active antiretroviral therapy on onset of Mycobacterium avium complex infection and cytomegalovirus disease in patients with AIDS [In Process Citation]. AIDS 14 16 (2000) 2593-2596
14. Bauer W.R., Turel Jr. A.P., and Johnson K.P. Progressive multifocal leukoencephalopathy and cytarabine. Remission with treatment. JAMA 226 2 (1973) 174-176
15. Bedri J., Weinstein W., De Gregorio P., et al. Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome. N Engl J Med 309 8 (1983) 492-493
16. Berger J.R. Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions. J Neurovirol 9 Suppl 1 (2003) 38-41
17. Berger J.R., and Koralnik I.J. Progressive multifocal leukoencephalopathy and natalizumab: unforeseen consequences. N Engl J Med 353 4 (2005) 414-416
18. Berger J.R., Kaszovitz B., Post M.J., et al. Progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection. A review of the literature with a report of sixteen cases. Ann Intern Med 107 1 (1987) 78-87
19. Berger J., Pall L., McArthur J., et al. A pilot study of recombinant alpha 2a interferon in the treatment of AIDS-related progressive multifocal leukoencephalopathy [abstract]. Neurology 42 Suppl 3 (1992) 257
20. Berger J.R., Scott G., Albrecht J., et al. Progressive multifocal leukoencephalopathy in HIV-1-infected children. AIDS 6 8 (1992) 837-841
21. Berger J.R., Levy R.M., Flomenhoft D., et al. Predictive factors for prolonged survival in acquired immunodeficiency syndrome-associated progressive multifocal leukoencephalopathy. Ann Neurol 44 3 (1998) 341-349
22. Berger J.R., Pall L., Lanska D., et al. Progressive multifocal leukoencephalopathy in patients with HIV infection. J Neurovirol 4 1 (1998) 59-68
23. Berger J.R., Miller C., et al. Are saliva and oropharyngeal secretions a source of JCV infection?. J Neurovirol 11 Suppl 2 (2005) 83
24. Bhigjee A.I., Patel V.B., Bhagwan B., et al. HIV and acute disseminated encephalomyelitis [letter]. S Afr Med J 89 3 (1999) 283-284
25. Blick G., Whiteside M., Griegor P., et al. Successful resolution of progressive multifocal leukoencephalopathy after combination therapy with cidofovir and cytosine arabinoside [see comments]. Clin Infect Dis 26 1 (1998) 191-192
26. Brambilla A.M., Castagna A., Novati R., et al. Remission of AIDS-associated progressive multifocal leukoencephalopathy after cidofovir therapy [letter]. J Neurol 246 8 (1999) 723-725
27. Brochet B., and Dousset V. Pathological correlates of magnetization transfer imaging abnormalities in animal models and humans with multiple sclerosis. Neurology 53 5 (1999) S12-S17
28. Brooks B.R., and Walker D.L. Progressive multifocal leukoencephalopathy. Neurol Clin 2 2 (1984) 299-313
29. Caldarelli-Stefano R., Vago L., Omodea-Zorini E., et al. Detection and typing of JC virus in autopsy brains and extraneural organs of AIDS patients and non-immunocompromised individuals. J Neurovirol 5 2 (1999) 125-133
30. Cavanaugh J., Greenbaum D., Marshall A., et al. Cerebral dymyelination associated with disorders of the reticuloendothelial system. Lancet 2 (1959) 524-529
31. Chang L., Ernst T., Tornatore C., et al. Metabolite abnormalities in progressive multifocal leukoencephalopathy by proton magnetic resonance spectroscopy. Neurology 48 4 (1997) 836-845
32. Chetty K.G., Kim R.C., and Mahutte C.K. Acute hemorrhagic leukoencephalitis during treatment for disseminated tuberculosis in a patient with AIDS. Int J Tuberc Lung Dis 1 6 (1997) 579-581
33. Church J.A. Reversible leukoencephalopathy in a patient with nucleoside analogue-associated mitochondrial DNA depletion and metabolic disease. AIDS 16 17 (2002) 2366-2367
34. Cinque P., Pierotti C., Vigano M.G., et al. The good and evil of HAART in HIV-related progressive multifocal leukoencephalopathy. J Neurovirol 7 4 (2001) 358-363
35. Cinque P., Bossolasco S., Brambilla A.M., et al. The effect of highly active antiretroviral therapy-induced immune reconstitution on development and outcome of progressive multifocal leukoencephalopathy: study of 43 cases with review of the literature. J Neurovirol 9 Suppl 1 (2003) 73-80
36. Clifford D.B., Yiannoutsos C., Glicksman M., et al. HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy. Neurology 52 3 (1999) 623-625
37. Coleman D.V., Wolfendale M.R., Daniel R.A., et al. A prospective study of human polyomavirus infection in pregnancy. J Infect Dis 142 1 (1980) 1-8
38. Conomy J., Beard N., Matsumoto H., et al. Cytarabine treatment of progressive multifocal leukoencephalopathy. JAMA 229 (1974) 1313-1316
39. Conway B., Halliday W.C., Brunhan R.C., et al. Human immunodeficiency virus-associated progressive multifocal leukoencephalopathy: apparent response to 3′-azido-3′-deoxythymidine. Rev Infect Dis 12 3 (1990) 479-482
40. d'Arminio Monforte A., Duca P.G., Vago L., et al. Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy. Neurology 54 9 (2000) 1856-1859
41. De Luca A., Ammassari A., Cingolani A., et al. Disease progression and poor survival of AIDS-associated progressive multifocal leukoencephalopathy despite highly active antiretroviral therapy [letter]. AIDS 12 14 (1998) 1937-1938
42. De Luca A., Fantoni M., Tartaglione T., et al. Response to cidofovir after failure of antiretroviral therapy alone in AIDS-associated progressive multifocal leukoencephalopathy. Neurology 52 4 (1999) 891-892
43. De Luca A., Giancola M.L., Ammassari A., et al. The effect of potent antiretroviral therapy and JC virus load in cerebrospinal fluid on clinical outcome of patients with AIDS-associated progressive multifocal leukoencephalopathy. J Infect Dis 182 4 (2000) 1077-1083
44. Di Giambenedetto S., Vago G., Pompucci A., et al. Fatal inflammatory AIDS-associated PML with high CD4 counts on HAART: a new clinical entity?. Neurology 63 12 (2004) 2452-2453
45. Dodge R.T. A case study: the use of cidofovir for the management of progressive multifocal leukoencephalopathy. J Assoc Nurses AIDS Care 10 4 (1999) 70-74
46. Dorries K. Progressive multifocal leucoencephalopathy: analysis of JC virus DNA from brain and kidney tissue. Virus Res 1 1 (1984) 25-38
47. Drews K., Bashir T., and Dorries K. Quantification of human polyomavirus JC in brain tissue and cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy by competitive PCR. J Virol Methods 84 1 (2000) 23-36
48. Du Pasquier R.A., and Koralnik I.J. Inflammatory reaction in progressive multifocal leukoencephalopathy: harmful or beneficial?. J Neurovirol 9 Suppl 1 (2003) 25-31
49. Du Pasquier R.A., Clark K.W., Smith P.S., et al. JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy. J Neurovirol 7 4 (2001) 318-322
50. Elovaara I., Iivanainen M., Valle S.L., et al. CSF protein and cellular profiles in various stages of HIV infection related to neurological manifestations. J Neurol Sci 78 3 (1987) 331-342
51. Elphick G.F., Querbes W., Jordan J.A., et al. The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science 306 5700 (2004) 1380-1383
52. Flaegstad T., Sundsfjord A., Arthur R.R., et al. Amplification and sequencing of the control regions of BK and JC virus from human urine by polymerase chain reaction. Virology 180 2 (1991) 553-560
53. Fong I.W., Britton C.B., Luinstra K.E., et al. Diagnostic value of detecting JC virus DNA in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. J Clin Microbiol 33 2 (1995) 484-486
54. Frisque R.J., Martin J.D., Padgett B.L., et al. Infectivity of the DNA from four isolates of JC virus. J Virol 32 2 (1979) 476-482
55. Frisque R.J., Bream G.L., and Cannella M.T. Human polyomavirus JC virus genome. J Virol 51 2 (1984) 458-469
56. Gardner S.D., Field A.M., Coleman D.V., et al. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1 7712 (1971) 1253-1257
57. Geschwind M.D., Skolasky R.I., Royal W.S., et al. The relative contributions of HAART and alpha-interferon for therapy of progressive multifocal leukoencephalopathy in AIDS. J Neurovirol 7 4 (2001) 353-357
58. Gillespie S.M., Chang Y., Lemp G., et al. Progressive multifocal leukoencephalopathy in persons infected with human immunodeficiency virus, San Francisco, 1981-1989. Ann Neurol 30 4 (1991) 597-604
59. Goodman A., Goodman L., Rall T., et al. The Pharmacological Basis of Therapeutics (1985), Macmillan, New York
60. Gray F., Belec L., Lescs M.C., et al. Varicella-zoster virus infection of the central nervous system in the acquired immune deficiency syndrome. Brain 117 Pt 5 (1994) 987-999
61. Hall C.D., Dafni U., Simpson D., et al. Failure of cytarabine in progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection. AIDS Clinical Trials Group 243 Team [see comments]. N Engl J Med 338 19 (1998) 1345-1351
62. Henin D., Smith T.W., and De Girolami U. Neuropathology of the spinal cord in the acquired immunodeficiency syndrome. Hum Pathol 23 10 (1992) 1106-1114
63. Henson J., Saffer J., and Furneaux H. The transcription factor Sp1 binds to the JC virus promoter and is selectively expressed in glial cells in human brain. Ann Neurol 32 1 (1992) 72-77
64. Hoffmann C., Horst H.A., Albrecht H., et al. Progressive multifocal leucoencephalopathy with unusual inflammatory response during antiretroviral treatment. J Neurol Neurosurg Psych 74 8 (2003) 1142-1144
65. Holman R.C., Janssen R.S., Buehler J.W., et al. Epidemiology of progressive multifocal leukoencephalopathy in the United States: analysis of national mortality and AIDS surveillance data. Neurology 41 11 (1991) 1733-1736
66. Holman R.C., Torok T.J., Belay E.D., et al. Progressive multifocal leukoencephalopathy in the United States, 1979-1994: increased mortality associated with HIV infection. Neuroepidemiology 17 6 (1998) 303-309
67. Hou J., and Major E.O. The efficacy of nucleoside analogs against JC virus multiplication in a persistently infected human fetal brain cell line. J Neurovirol 4 4 (1998) 451-456
68. Houff S.A., Major E.O., Katz D.A., et al. Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. N Engl J Med 318 5 (1988) 301-305
69. Huang S.S., Skolasky R.L., Dal Pan G.J., et al. Survival prolongation in HIV-associated progressive multifocal leukoencephalopathy treated with alpha-interferon: an observational study. J Neurovirol 4 3 (1998) 324-332
70. Inui K., Miyagawa H., Sashihara J., et al. Remission of progressive multifocal leukoencephalopathy following highly active antiretroviral therapy in a patient with HIV infection. Brain Dev 21 6 (1999) 416-419
71. Iranzo A., Marti-Fabregas J., Domingo P., et al. Absence of thallium-201 brain uptake in progressive multifocal leukoencephalopathy in AIDS patients. Acta Neurol Scand 100 2 (1999) 102-105
72. Kalayjian R.C., Cohen M.L., Bonomo R.A., et al. Cytomegalovirus ventriculoencephalitis in AIDS. A syndrome with distinct clinical and pathologic features. Medicine (Baltimore) 72 2 (1993) 67-77
73. Kastrup O., Wanke I., Esser S., et al. Evolution of purely infratentorial PML under HAART: negative outcome under rapid immune reconstitution. Clin Neurol Neurosurg 107 6 (2005) 509-513
74. Katz R.L., Alappattu C., Glass J.P., et al. Cerebrospinal fluid manifestations of the neurologic complications of human immunodeficiency virus infection. Acta Cytol 33 2 (1989) 233-244
75. Kerr D.A., Chang C.F., Gordon J., et al. Inhibition of human neurotropic virus (JCV) DNA replication in glial cells by camptothecin. Virology 196 2 (1993) 612-618
76. Khalili K., Rappaport J., and Khoury G. Nuclear factors in human brain cells bind specifically to the JCV regulatory region. EMBO J 7 4 (1988) 1205-1210
77. Kleinschmidt-DeMasters B.K., and Tyler K.L. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 353 4 (2005) 369-374
78. Koralnik I.J. Overview of the cellular immunity against JC virus in progressive multifocal leukoencephalopathy. J Neurovirol 8 Suppl 2 (2002) 59-65
79. Koralnik I.J., Du Pasquier R.A., and Letvin N.L. JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy. J Virol 75 7 (2001) 3483-3487
80. Koralnik I.J., Wuthrich C., Dang X., et al. JC virus granule cell neuronopathy: a novel clinical syndrome distinct from progressive multifocal leukoencephalopathy. Ann Neurol 57 4 (2005) 576-580
81. Krupp L.B., Lipton R.B., Swerdlow M.L., et al. Progressive multifocal leukoencephalopathy: clinical and radiographic features. Ann Neurol 17 4 (1985) 344-349
82. Kuchelmeister K., Gullotta F., Bergmann M., et al. Progressive multifocal leukoencephalopathy (PML) in the acquired immunodeficiency syndrome (AIDS). A neuropathological autopsy study of 21 cases. Pathol Res Pract 189 2 (1993) 163-173
83. Kure K., Llena J.F., Lyman W.D., et al. Human immunodeficiency virus-1 infection of the nervous system: an autopsy study of 268 adult, pediatric, and fetal brains. Hum Pathol 22 7 (1991) 700-710
84. Lang W., Miklossy J., Deruaz J.P., et al. Neuropathology of the acquired immune deficiency syndrome (AIDS): a report of 135 consecutive autopsy cases from Switzerland. Acta Neuropathol 77 4 (1989) 379-390
85. Langer-Gould A., Atlas S.W., Green A.J., et al. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 353 4 (2005) 375-381
86. Lidman C., Lindqvist L., Mathiesen T., et al. Progressive multifocal leukoencephalopathy in AIDS. AIDS 5 8 (1991) 1039-1041
87. London W.T., Houff S.A., Madden D.L., et al. Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus). Science 201 4362 (1978) 1246-1249
88. Lynch K.J., and Frisque R.J. Identification of critical elements within the JC virus DNA replication origin. J Virol 64 12 (1990) 5812-5822
89. Lynch K.J., and Frisque R.J. Factors contributing to the restricted DNA replicating activity of JC virus. Virology 180 1 (1991) 306-317
90. Major E.O., Amemiya K., Elder G., et al. Glial cells of the human developing brain and B cells of the immune system share a common DNA binding factor for recognition of the regulatory sequences of the human polyomavirus, JCV. J Neurosci Res 27 4 (1990) 461-471
91. Major E.O., Amemiya K., Tornatore C.S., et al. Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin Microbiol Rev 5 1 (1992) 49-73
92. Marra C.M., Rajicic N., Barner D.E., et al. A pilot study of cidofovir for progressive multifocal leukoencephalopathy in AIDS. AIDS 16 13 (2002) 1791-1797
93. Marshall D.W., Brey R.L., Cahill W.T., et al. Spectrum of cerebrospinal fluid findings in various stages of human immunodeficiency virus infection. Arch Neurol 45 9 (1988) 954-958
94. Martin J.D., King D.M., Slauch J.M., et al. Differences in regulatory sequences of naturally occurring JC virus variants. J Virol 53 1 (1985) 306-311
95. Maschke M., Kastrup O., Esser S., et al. Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psych 69 3 (2000) 376-380
96. Mazlo M., and Herndon R. Progressive multifocal leukoencephalopathy: ultrastructural findings in two brain biopsies. Neuropathol Appl Neurobiol 3 (1977) 323-339
97. Mazlo M., and Tariska I. Are astrocytes infected in progressive multifocal leukoencephalopathy (PML)?. Acta Neuropathol 56 1 (1982) 45-51
98. McGuire D., Barhite S., Hollander H., et al. JC virus DNA in cerebrospinal fluid of human immunodeficiency virus-infected patients: predictive value for progressive multifocal leukoencephalopathy. Ann Neurol 37 3 (1995) 395-399 [published erratum appears in
99. McGuire D., Barhite S., Hollander H., et al. JC virus DNA in cerebrospinal fluid of human immunodeficiency virus-infected patients: predictive value for progressive multifocal leukoencephalopathy. Ann Neurol 37 5 (1995) 687
100. Messite J., and Stellman S.D. Accuracy of death certificate completion: the need for formalized physician training. JAMA 275 10 (1996) 794-796
101. Meylan P.R., Vuadens P., Maeder P., et al. Monitoring the response of AIDS-related progressive multifocal leukoencephalopathy to HAART and cidofovir by PCR for JC virus DNA in the CSF. Eur Neurol 41 3 (1999) 172-174
102. Miller J.R., Barrett R.E., Britton C.B., et al. Progressive multifocal leukoencephalopathy in a male homosexual with T-cell immune deficiency. N Engl J Med 307 23 (1982) 1436-1438
103. Miller R.F., Lucas S.B., Hall-Craggs M.A., et al. Comparison of magnetic resonance imaging with neuropathological findings in the diagnosis of HIV and CMV associated CNS disease in AIDS. J Neurol Neurosurg Psych 62 4 (1997) 346-351
104. Miralles P., Berenguer J., Garcia de Viedma D., et al. Treatment of AIDS-associated progressive multifocal leukoencephalopathy with highly active antiretroviral therapy. AIDS 12 18 (1998) 2467-2472
105. Monaco M.C., Jensen P.N., Hou J., et al. Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection. J Virol 72 12 (1998) 9918-9923
106. Morriss M.C., Rutstein R.M., Rudy B., et al. Progressive multifocal leukoencephalopathy in an HIV-infected child. Neuroradiology 39 2 (1997) 142-144
107. Myers C., Frisque R.J., and Arthur R.R. Direct isolation and characterization of JC virus from urine samples of renal and bone marrow transplant patients. J Virol 63 10 (1989) 4445-4449
108. Nelson P.K., Masters L.T., Zagzag D., et al. Angiographic abnormalities in progressive multifocal leukoencephalopathy: an explanation based on neuropathologic findings. AJNR Am J Neuroradiol 20 3 (1999) 487-494
109. O'Reilly S. Efficacy of camptothecin in progressive multifocal leucoencephalopathy. Lancet 350 9073 (1997) 291
110. O'Riordan T., Daly P., Hutchinson M., et al. Progressive multifocal leukoencephalopathy: remission with cytarabine. J Infect Dis 20 (1990) 51-54
111. Ormerod L., Rhodes R., Gross S.A., et al. Ophthalmologic manifestations of acquired immune deficiency syndrome-associated progressive multifocal leukoencephalopathy. Ophthalmology 103 (1996) 899-906
112. Padgett B.L., and Walker D.L. Virologic and serologic studies of progressive multifocal leukoencephalopathy. Prog Clin Biol Res 105 (1983) 107-117
113. Padgett B.L., Walker D.L., ZuRhein G.M., et al. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1 7712 (1971) 1257-1260
114. Pho M.T., Ashok A., Atwood W.J., et al. JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis. J Virol 74 5 (2000) 2288-2292
115. Port J.D., Miseljic S., Lee R.R., et al. Progressive multifocal leukoencephalopathy demonstrating contrast enhancement on MRI and uptake of thallium-201: a case report. Neuroradiology 41 12 (1999) 895-898
116. Post M.J., Yiannoutsos C., Simpson D., et al. Progressive multifocal leukoencephalopathy in AIDS: are there any MR findings useful to patient management and predictive of patient survival? AIDS Clinical Trials Group, 243 Team. AJNR Am J Neuroradiol 20 10 (1999) 1896-1906
117. Querbes W., Benmerah A., Tosoni D., et al. A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway. J Virol 78 1 (2004) 250-256
118. Rand K.H., Johnson K.P., Rubinstein L.J., et al. Adenine arabinoside in the treatment of progressive multifocal leukoencephalopathy: use of virus-containing cells in the urine to assess response to therapy. Ann Neurol 1 5 (1977) 458-462
119. Richardson E.J. Progressive multifocal leukoencephalopathy. In: Vinken P., and Bruyn G. (Eds). Handbook of Clinical Neurology Vol. 9 (1970), Elsevier, New York 485-499
120. Richardson Jr. E.P. Our evolving understanding of progressive multifocal leukoencephalopatha. Ann N Y Acad Sci 230 (1974) 358-364
121. Sacktor N. The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. J Neurovirol 8 Suppl 2 (2002) 115-121
122. Sadler M., Chinn R., Healy J., et al. New treatments for progressive multifocal leukoencephalopathy in HIV-1-infected patients. AIDS 12 5 (1998) 533-535
123. Safdar A., Rubocki R.J., Horvath J.A., et al. Fatal immune restoration disease in human immunodeficiency virus type 1-infected patients with progressive multifocal leukoencephalopathy: impact of antiretroviral therapy-associated immune reconstitution. Clin Infect Dis 35 10 (2002) 1250-1257
124. Samorei I.W., Schmid M., Pawlita M., et al. High sensitivity detection of JC-virus DNA in postmortem brain tissue by in situ PCR. J Neurovirol 6 1 (2000) 61-74
125. Satishchandra P., Nalini A., Gourie-Devi M., et al. Profile of neurologic disorders associated with HIV/AIDS from Bangalore, south India (1989-96). Indian J Med Res 111 (2000) 14-23
126. Scaravilli F., Daniel S.E., Harcourt-Webster N., et al. Chronic basal meningitis and vasculitis in acquired immunodeficiency syndrome. A possible role for human immunodeficiency virus [see comments]. Arch Pathol Lab Med 113 2 (1989) 192-195
127. Selik R.M., Karon J.M., and Ward J.W. Effect of the human immunodeficiency virus epidemic on mortality from opportunistic infections in the United States in 1993. J Infect Dis 176 3 (1997) 632-636
128. Silverman L., and Rubinstein L.J. Electron microscopic observations on a case of progressive multifocal leukoencephalopathy. Acta Neuropathol (Berl) 5 2 (1965) 215-224
129. Singer C., Berger J.R., Bowen B.C., et al. Akinetic-rigid syndrome in a 13-year-old girl with HIV-related progressive multifocal leukoencephalopathy. Mov Disord 8 1 (1993) 113-116
130. Sparano J.A., Anand K., Desai J., et al. Effect of highly active antiretroviral therapy on the incidence of HIV-associated malignancies at an urban medical center. J Acquir Immune Defic Syndr 21 Suppl 1 (1999) S18-S22
131. Steiger M.J., Tarnesby G., Gabe S., et al. Successful outcome of progressive multifocal leukoencephalopathy with cytarabine and interferon. Ann Neurol 33 4 (1993) 407-411
132. Stoner G., and Ryschkewitsch C. Evidence of JC virus in two progressive multifocal leukoencephalopathy (PML) brains previously reported to be infected with SC40. J Neuropathol Exp Neurol 50 (1991) 342
133. Sweeney B.J., Manji H., Miller R.F., et al. Cortical and subcortical JC virus infection: two unusual cases of AIDS associated progressive multifocal leukoencephalopathy. J Neurol Neurosurg Psychiatry 57 8 (1994) 994-997
134. Tada H., Lashgari M., Rappaport J., et al. Cell type-specific expression of JC virus early promoter is determined by positive and negative regulation. J Virol 63 1 (1989) 463-466
135. Taguchi F., Kajioka L., Miyamura T., et al. Prevalence rate and age of acquisition of antibodies against JC virus and BK virus in human sera. Microbiol Immunol 26 11 (1982) 1057-1064
136. Tamura T., Inoue T., Nagata K., et al. Enhancer of human polyoma JC virus contains nuclear factor I-binding sequences; analysis using mouse brain nuclear extracts. Biochem Biophys Res Commun 157 2 (1988) 419-425
137. Tantisiriwat W., Tebas P., Clifford D.B., et al. Progressive multifocal leukoencephalopathy in patients with AIDS receiving highly active antiretroviral therapy. Clin Infect Dis 28 5 (1999) 1152-1154
138. Taoufik Y., Gasnault J., Karaterki A., et al. Prognostic value of JC virus load in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. J Infect Dis 178 6 (1998) 1816-1820
139. Tashiro K., Doi S., Moriwaka F., et al. Progressive multifocal leucoencephalopathy with magnetic resonance imaging verification and therapeutic trials with interferon. J Neurol 234 6 (1987) 427-429
140. Thurnher M.M., Post M.J., Rieger A., et al. Initial and follow-up MR imaging findings in AIDS-related progressive multifocal leukoencephalopathy treated with highly active antiretroviral therapy. AJNR Am J Neuroradiol 22 5 (2001) 977-984
141. Tominaga T., Yogo Y., Kitamura T., et al. Persistence of archetypal JC virus DNA in normal renal tissue derived from tumor-bearing patients. Virology 186 2 (1992) 736-741
142. Tooze J. Human papovaviruses. In: Tooze J. (Ed). Molecular Biology of Tumor Viruses Vol. 2 (1980), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
143. Tornatore C., Berger J., Houft S.A., et al. Detection of JC viral genome in the lymphocytes of non-PML HIV positive patients: association with B cell lymphopenia. Neurology 42 Suppl 3 (1992) 211
144. Tornatore C., Berger J.R., Houft J.L., et al. Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathy. Ann Neurol 31 4 (1992) 454-462
145. Van Assche G., Van Ranst M., Sciot R., et al. Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 353 4 (2005) 362-368
146. Van Horn G., Bastian F., and Moake J.L. Progressive multifocal leukoencephalopathy: failure of response to transfer factor and cytarabine. Neurology 28 (1978) 794-797
147. Verbraak F.D., Boom R., Wertheim-van Dillen P.M., et al. Influence of highly active antiretroviral therapy on the development of CMV disease in HIV positive patients at high risk for CMV disease. Br J Ophthalmol 83 10 (1999) 1186-1189
148. Vollmer-Haase J., Young P., and Ringelstein E.B. Efficacy of camptothecin in progressive multifocal leucoencephalopathy. Lancet 349 9062 (1997) 1366
149. Von Einsiedel R.W., Fife T.D., Aksamit A.J., et al. Progressive multifocal leukoencephalopathy in AIDS: a clinicopathologic study and review of the literature. J Neurol 240 7 (1993) 391-406
150. Walker D., and Padgett B. The epidemiology of human polyomaviruses. In: Sever J., and Madden D. (Eds). Polyomaviruses and Human Neurological Disease (1983), Alan R. Liss, New York 99-106
151. Walker D., and Padgett B. Progressive multifocal leukoencephalopathy. In: Fraenkel-Conrat H., and Wagner R. (Eds). Comprehensive Virology (1983), Plenum, New York 161-193
152. Walker D.L., Padgett B.L., ZuRhein G.M., et al. Human papovavirus (JC): induction of brain tumors in hamsters. Science 181 100 (1973) 674-676
153. Weber F., Goldmann C., Kramer M., et al. Cellular and humoral immune response in progressive multifocal leukoencephalopathy. Ann Neurol 49 5 (2001) 636-642
154. Weber T., Turner R., Frye S., et al. JC virus detected by polymerase chain reaction in cerebrospinal fluid of AIDS patients with progressive multifocal leukoencephalopathy. Neurological and neuropsychological complications of HIV infection. Proceedings of the Satellite Meeting of the International Conference on AIDS (1990)
155. Weber T., Turner R.W., Frye S., et al. Progressive multifocal leukoencephalopathy diagnosed by amplification of JC virus-specific DNA from cerebrospinal fluid. AIDS 8 1 (1994) 49-57
156. Whiteman M.L., Post M.J., Berger J.R., et al. Progressive multifocal leukoencephalopathy in 47 HIV-seropositive patients: neuroimaging with clinical and pathologic correlation. Radiology 187 1 (1993) 233-240
157. Wolinsky J.S., Johnson K.P., Rand K., et al. Progressive multifocal leukoencephalopathy: clinical pathological correlates and failure of a drug trial in two patients. Trans Am Neurol Assoc 101 (1976) 81-82
158. Wong M.C., Suite N.D., and Labar D.R. Seizures in human immunodeficiency virus infection. Arch Neurol 47 6 (1990) 640-642
159. Wroblewska Z., Wellish M., and Gilden D. Growth of JC virus in adult human brain cell cultures. Arch Virol 65 (1980) 141-148
160. Wyen C., Hoffmann C., Schmeisser N., et al. Progressive multifocal leukoencephalopathy in patients on highly active antiretroviral therapy: survival and risk factors of death. J Acquir Immune Defic Syndr 37 2 (2004) 1263-1268
161. Yiannoutsos C.T., Major E.O., Curfman B., et al. Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy. Ann Neurol 45 6 (1999) 816-821
162. Yogo T., Kitamura T., Sugimoto C., et al. Isolation of a possible archetypal JC virus DNA sequence from nonimmunocompromised individuals. J Virol 64 (1990) 3139-3143
163. Yogo Y., Kitamura T., Sugimoto C., et al. Sequence rearrangement in JC virus DNAs molecularly cloned from immunosuppressed renal transplant patients. J Virol 65 5 (1991) 2422-2428
164. ZuRhein G. Particles resembling papovavirions in human cerebral demyelinating disease. Science 148 (1965) 1477-1479
165. ZuRhein G. Polyona-like virions in a human demyelinating disease. Acta Neuro Pathol (Berl) 8 (1967) 57-68