A case of progressive multifocal leukoencephalopathy in a patient treated with infliximab

Arthritis and Rheumatism

Volumn 62, Issue 11, 2010, Pages 3191-3195

  Kumar, Deepak ^a   Bouldin, Thomas W ^a   Berger, Robert G ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE MODIFYING ANTIRHEUMATIC DRUG; HYDROXYCHLOROQUINE; INFLIXIMAB; METHOTREXATE; PREDNISONE;

AGED; ARTICLE; BRAIN BIOPSY; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; DEMYELINATION; DRUG DOSE TITRATION; DRUG WITHDRAWAL; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; LUMBAR PUNCTURE; MALE; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; RHEUMATOID ARTHRITIS; VERTIGO; WHITE MATTER;

AGED; ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; HUMANS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; MAGNETIC RESONANCE IMAGING; MALE; METHOTREXATE; NERVE FIBERS, MYELINATED; PREDNISONE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78249286239     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27687     Document Type: Article

References (19)

1. Maini RN, Feldmann M,. How does infliximab work in rheumatoid arthritis? Arthritis Res 2002; 4 Suppl 2: S22 - 8.
2. Johnson & Johnson. Remicade becomes first anti-TNF biologic therapy to treat one million patients worldwide. November 2007. URL:.
3. Carson KR, Focosi D, Major EO, Petrini M, Richey EA, West DP, et al. Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a review from the Research on Adverse Drug Events and Reports (RADAR) project. Lancet Oncol 2009; 10: 816 - 24.
4. Piccinni C, Sacripanti C, Poluzzi E, Motola D, Magro L, Moretti U, et al. Stronger association of drug-induced progressive multifocal leukoencephalopathy (PML) with biological immunomodulating agents. Eur J Clin Pharmacol 2010; 66: 199 - 206.
5. Yokoo H, Nakazato Y, Harigaya Y, Sasaki N, Igeta Y, Itoh H,. Massive myelinolytic leukoencephalopathy in a patient medicated with low-dose oral methotrexate for rheumatoid arthritis: an autopsy report. Acta Neuropathol 2007; 114: 425 - 30.
6. Renard D, Westhovens R, Vandenbussche E, Vandenberghe R,. Reversible posterior leucoencephalopathy during oral treatment with methotrexate. J Neurol 2004; 251: 226 - 8.
7. Raghavendra S, Nair MD, Chemmanam T, Krishnamoorthy T, Radhakrishnan VV, Kuruvilla A,. Disseminated necrotizing leukoencephalopathy following low-dose oral methotrexate. Eur J Neurol 2007; 14: 309 - 14.
8. Worthley SG, McNeil JD,. Leukoencephalopathy in a patient taking low dose oral methotrexate therapy for rheumatoid arthritis. J Rheumatol 1995; 22: 335 - 7.
9. Shprecher D, Frech T, Chin S, Eskandari R, Steffens J,. Progressive multifocal leucoencephalopathy associated with lupus and methotrexate overdose. Lupus 2008; 17: 1029 - 32.
10. Fleischmann RM,. Progressive multifocal leukoencephalopathy following rituximab treatment in a patient with rheumatoid arthritis. Arthritis Rheum 2009; 60: 3225 - 8.
11. US Food and Drug Administration. URL:.
12. Cross AH, Stark JL, Lauber J, Ramsbottom MJ, Lyons JA,. Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 2006; 180: 63 - 70.
13. + progressive multifocal leukoencephalopathy patients with a CTL response specific for a commonly recognized JC virus epitope. J Immunol 2002; 168: 499 - 504.
14. Du Pasquier RA, Kuroda MJ, Schmitz JE, Zheng Y, Martin K, Peyerl FW, et al. Low frequency of cytotoxic T lymphocytes against the novel HLA-A*0201-restricted JC virus epitope VP1(p36) in patients with proven or possible progressive multifocal leukoencephalopathy. J Virol 2003; 77: 11918 - 26.
15. Du Pasquier RA, Kuroda MJ, Zheng Y, Jean-Jacques J, Letvin NL, Koralnik IJ,. A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy. Brain 2004; 127: 1970 - 8.
16. Du Pasquier RA, Schmitz JE, Jean-Jacques J, Zheng Y, Gordon J, Khalili K, et al. Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals. J Virol 2004; 78: 10206 - 10.
17. Marzocchetti A, Tompkins T, Clifford DB, Gandhi RT, Kesari S, Berger JR, et al. Determinants of survival in progressive multifocal leukoencephalopathy. Neurology 2009; 73: 1551 - 8.
18. Gottlieb AB, Chamian F, Masud S, Cardinale I, Abello MV, Lowes MA, et al. TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques. J Immunol 2005; 175: 2721 - 9.
19. - T cell compartment in peripheral blood in patients with rheumatoid arthritis. Rheumatol Int 2004; 24: 351 - 4.