Quantifying the evolution of vascular barrier disruption in advanced atherosclerosis with semipermeant nanoparticle contrast agents

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Zhang, Huiying ^a   Zhang, Lei ^a   Myerson, Jacob ^a,b   Bibee, Kristin ^a   Scott, Michael ^a   Allen, John ^a   Sicard, Gregorio ^c   Lanza, Gregory ^a,b   Wickline, Samuel ^a,b  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CHOLESTEROL; CONTRAST MEDIUM; FLUORINE; FLUOROCARBON; NANOPARTICLE; DIAGNOSTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL PERMEABILITY; CELL MEMBRANE PERMEABILITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTRAST ENHANCEMENT; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; EROSION; FLUORINE NUCLEAR MAGNETIC RESONANCE; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; RABBIT; SIGNAL NOISE RATIO; ANIMAL; CHEMISTRY; CLINICAL TRIAL (TOPIC); HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PERMEABILITY; TIME; VASCULAR ENDOTHELIUM;

ORYCTOLAGUS CUNICULUS;

ANIMALS; CLINICAL TRIALS AS TOPIC; CONTRAST MEDIA; ENDOTHELIUM, VASCULAR; HUMANS; MAGNETIC RESONANCE IMAGING; NANOPARTICLES; PERMEABILITY; PLAQUE, ATHEROSCLEROTIC; RABBITS; TIME FACTORS;

EID: 80054765284     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026385     Document Type: Article

References (51)

1. Arora R, Rai F, (2008) Atherothrombosis and the Management of the Vulnerable Vascular Patient. Am J Ther.
2. Davies MJ, Thomas AC, (1985) Plaque fissuring-the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J 53: 363-373.
3. Falk E, Shah PK, Fuster V, (1995) Coronary plaque disruption. Circulation 92: 657-671.
4. Farb A, Burke AP, Tang AL, Liang TY, Mannan P, et al. (1996) Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. Circulation 93: 1354-1363.
5. Schwartz RS, Burke A, Farb A, Kaye D, Lesser JR, et al. (2009) Microemboli and microvascular obstruction in acute coronary thrombosis and sudden coronary death: relation to epicardial plaque histopathology. J Am Coll Cardiol 54: 2167-2173.
6. Borissoff JI, Spronk HM, Heeneman S, ten Cate H, (2009) Is thrombin a key player in the 'coagulation-atherogenesis' maze? Cardiovasc Res 82: 392-403.
7. Chen YL, Jan KM, Lin HS, Chien S, (1997) Relationship between endothelial cell turnover and permeability to horseradish peroxidase. Atherosclerosis 133: 7-14.
8. Davies MJ, Gordon JL, Gearing AJ, Pigott R, Woolf N, et al. (1993) The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol 171: 223-229.
9. Frank PG, Pavlides S, Lisanti MP, (2009) Caveolae and transcytosis in endothelial cells: role in atherosclerosis. Cell Tissue Res 335: 41-47.
10. Gates PE, Strain WD, Shore AC, (2009) Human endothelial function and microvascular ageing. Exp Physiol 94: 311-316.
11. Lee K, Forudi F, Saidel GM, Penn MS, (2005) Alterations in internal elastic lamina permeability as a function of age and anatomical site precede lesion development in apolipoprotein E-null mice. Circ Res 97: 450-456.
12. Lee K, Saidel GM, Penn MS, (2008) Permeability change of arterial endothelium is an age-dependent function of lesion size in apolipoprotein E-null mice. Am J Physiol Heart Circ Physiol 295: H2273-2279.
13. Tabas I, Williams KJ, Boren J, (2007) Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation 116: 1832-1844.
14. Schapira K, Heeneman S, Daemen MJ, (2007) Animal models to study plaque vulnerability. Curr Pharm Des 13: 1013-1020.
15. Durand E, Scoazec A, Lafont A, Boddaert J, Al Hajzen A, et al. (2004) In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation: a clue to the understanding of the mechanisms of thrombotic plaque erosion. Circulation 109: 2503-2506.
16. Staiger K, Staiger H, Weigert C, Haas C, Haring HU, et al. (2006) Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation. Diabetes 55: 3121-3126.
17. Shaish A, Keren G, Chouraqui P, Levkovitz H, Harats D, (2001) Imaging of aortic atherosclerotic lesions by (125)I-LDL, (125)I-oxidized-LDL, (125)I-HDL and (125)I-BSA. Pathobiology 69: 225-229.
18. Erusalimsky JD, (2009) Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol 106: 326-332.
19. Minamino T, Komuro I, (2007) Vascular cell senescence: contribution to atherosclerosis. Circ Res 100: 15-26.
20. Mun GI, Boo YC, (2010) Identification of CD44 as a senescence-induced cell adhesion gene responsible for the enhanced monocyte recruitment to senescent endothelial cells. Am J Physiol Heart Circ Physiol 298: H2102-2111.
21. Op den Buijs J, Musters M, Verrips T, Post JA, Braam B, et al. (2004) Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing, and telomere shortening. Am J Physiol Heart Circ Physiol 287: H2651-2658.
22. Sima AV, Stancu CS, Simionescu M, (2009) Vascular endothelium in atherosclerosis. Cell Tissue Res 335: 191-203.
23. Wickline SA, Lanza GM, (2003) Nanotechnology for molecular imaging and targeted therapy. Circulation 107: 1092-1095.
24. Wickline SA, Neubauer AM, Winter P, Caruthers S, Lanza G, (2006) Applications of nanotechnology to atherosclerosis, thrombosis, and vascular biology. Arterioscler Thromb Vasc Biol 26: 435-441.
25. Wickline SA, Neubauer AM, Winter PM, Caruthers SD, Lanza GM, (2007) Molecular imaging and therapy of atherosclerosis with targeted nanoparticles. J Magn Reson Imaging 25: 667-680.
26. Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, et al. (2011) A prospective natural-history study of coronary atherosclerosis. N Engl J Med 364: 226-235.
27. Morawski AM, Winter PM, Yu X, Fuhrhop RW, Scott MJ, et al. (2004) Quantitative "magnetic resonance immunohistochemistry" with ligand-targeted (19)F nanoparticles. Magn Reson Med 52: 1255-1262.
28. Partlow KC, Chen J, Brant JA, Neubauer AM, Meyerrose TE, et al. (2007) 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J 21: 1647-1654.
29. Waters EA, Chen J, Allen JS, Zhang H, Lanza GM, et al. (2008) Detection and quantification of angiogenesis in experimental valve disease with integrin-targeted nanoparticles and 19-fluorine MRI/MRS. J Cardiovasc Magn Reson 10: 43.
30. Kolodgie FD, Burke AP, Farb A, Weber DK, Kutys R, et al. (2002) Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion. Arterioscler Thromb Vasc Biol 22: 1642-1648.
31. Abela GS, Aziz K, Vedre A, Pathak DR, Talbott JD, et al. (2009) Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes. Am J Cardiol 103: 959-968.
32. Simionescu M, (2007) Implications of early structural-functional changes in the endothelium for vascular disease. Arterioscler Thromb Vasc Biol 27: 266-274.
33. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, et al. (2003) From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation 108: 1772-1778.
34. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, et al. (2003) From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 108: 1664-1672.
35. Jaffer FA, Libby P, Weissleder R, (2007) Molecular imaging of cardiovascular disease. Circulation 116: 1052-1061.
36. Wickline SA, Mason RP, Caruthers SD, Chen J, Winter PM, et al. (2010) Fluorocarbon agents for quantitative multimodal molecular imaging and targeted therapeutics. In: Weissleder R, Ross BD, Rehemtulla A, Gambhir SS, editors. Molecular Imaging: Principles and Practice pp. 542-573.
37. Brix G, Griebel J, Kiessling F, Wenz F, (2010) Tracer kinetic modelling of tumour angiogenesis based on dynamic contrast-enhanced CT and MRI measurements. Eur J Nucl Med Mol Imaging 37 (Suppl 1): S30-51.
38. Calcagno C, Mani V, Ramachandran S, Fayad ZA, (2010) Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) of atherosclerotic plaque angiogenesis. Angiogenesis 13: 87-99.
39. Pedersen SF, Thrysoe SA, Paaske WP, Thim T, Falk E, et al. (2011) CMR assessment of endothelial damage and angiogenesis in porcine coronary arteries using gadofosveset. J Cardiovasc Magn Reson 13: 10.
40. Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL, (2010) Imaging atherosclerosis and vulnerable plaque. J Nucl Med 51 (Suppl 1): 51S-65S.
41. Underhill HR, Hatsukami TS, Fayad ZA, Fuster V, Yuan C, (2010) MRI of carotid atherosclerosis: clinical implications and future directions. Nat Rev Cardiol 7: 165-173.
42. Yuan C, Kerwin WS, Ferguson MS, Polissar N, Zhang S, et al. (2002) Contrast-enhanced high resolution MRI for atherosclerotic carotid artery tissue characterization. J Magn Reson Imaging 15: 62-67.
43. Yuan C, Mitsumori LM, Beach KW, Maravilla KR, (2001) Carotid atherosclerotic plaque: noninvasive MR characterization and identification of vulnerable lesions. Radiology 221: 285-299.
44. Peter A, Weigert C, Staiger H, Rittig K, Cegan A, et al. (2008) Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity. Am J Physiol Endocrinol Metab 295: E339-349.
45. van Nieuw Amerongen GP, Vermeer MA, Negre-Aminou P, Lankelma J, Emeis JJ, et al. (2000) Simvastatin improves disturbed endothelial barrier function. Circulation 102: 2803-2809.
46. Yeh HI, Lu CS, Wu YJ, Chen CC, Hong RC, et al. (2003) Reduced expression of endothelial connexin37 and connexin40 in hyperlipidemic mice: recovery of connexin37 after 7-day simvastatin treatment. Arterioscler Thromb Vasc Biol 23: 1391-1397.
47. Hayashi T, Iguchi A, (2010) Possibility of the regression of atherosclerosis through the prevention of endothelial senescence by the regulation of nitric oxide and free radical scavengers. Geriatr Gerontol Int 10: 115-130.
48. Vasa M, Breitschopf K, Zeiher AM, Dimmeler S, (2000) Nitric oxide activates telomerase and delays endothelial cell senescence. Circ Res 87: 540-542.
49. Winter PM, Morawski AM, Caruthers SD, Fuhrhop RW, Zhang H, et al. (2003) Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles. Circulation 108: 2270-2274.
50. Flaim SF, (1994) Pharmacokinetics and side effects of perfluorocarbon-based blood substitutes. Artif Cells Blood Substit Immobil Biotechnol 22: 1043-1054.
51. Liu Y, Liu Y, Wang C, Qu S, Deng F, (2000) Microcalorimetric studies of the inhibition of sodium azide on the mitochondrial metabolism of fish liver tissue. Thermochimica Acta 351: 4.