Chronic sympathetic activation promotes downregulation of β-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction

Pflugers Archiv European Journal of Physiology

Volumn 462, Issue 4, 2011, Pages 529-543

  Soltysinska, Ewa ^a   Thiele, Stefanie ^b   Olesen, Søren Peter ^a   Osadchii, Oleg E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

adrenoceptor; Downregulation; Structural remodeling; Sympathetic activation; Systolic dysfunction

Indexed keywords

ADENOSINE PHOSPHATE; ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; ISOPRENALINE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL CAV1.2; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL KV7.1;

ADRENERGIC STIMULATION; ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; DRUG TOLERABILITY; GUINEA PIG; HEART CONTRACTION; HEART MUSCLE POTENTIAL; HEART MUSCLE REFRACTORY PERIOD; HEART WEIGHT; LONG TERM CARE; MALE; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SYSTOLIC DYSFUNCTION;

ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM CHANNELS, L-TYPE; CYCLIC AMP; DOWN-REGULATION; FORSKOLIN; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GUINEA PIGS; ISOPROTERENOL; KCNQ1 POTASSIUM CHANNEL; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; RECEPTORS, ADRENERGIC, BETA; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL; SIGNAL TRANSDUCTION; SYSTOLE; VENTRICULAR REMODELING;

EID: 80054759363     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-1005-7     Document Type: Article

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