Cyclic AMP levels in ventricular myocytes from noradrenaline-treated guinea-pigs

European Journal of Pharmacology

Volumn 310, Issue 2-3, 1996, Pages 235-242

  Wynne, Dylan G ^a   Del Monte, Federica ^a   Harding, Sian E ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

cAMP; Cardiac myocyte; Contractility; Adrenoceptor desensitization

Indexed keywords

BETA ADRENERGIC RECEPTOR; CYCLIC AMP; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; NORADRENALIN; PHOSPHODIESTERASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; GUINEA PIG; HEART FAILURE; HEART VENTRICLE WALL; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030605956     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00380-9     Document Type: Article

References (41)

1. Adie, E.J. and G. Milligan, 1994. Regulation of basal adenylate cyclase activity in neuroblastoma X glioma hybrid. NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade, Biochem. J. 303, 803.
2. Bohm, M., P. Gierschik, K.H. Jakobs, P. Schnabel, B. Kemkes and E. Erdmann, 1989, Localization of a 'postreceptor' defect in human dilated cardiomyopathy. Am. J. Cardiol. 64, 812.
3. Bohm, M., B. Reiger. R.H.G. Schwinger and E. Erdmann, 1994, cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium, Cardiovasc. Res. 28, 1713.
4. Bradford. M.M., 1976, A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding, Analyt. Biochem. 72, 248.
5. Bristow, M.R.. R.E. Hershberger, J. D. Port, E.M. Gilbert, A. Sandoval, R. Rasmussen, A.E. Cates and A.M. Feldman, 1990, Beta-adrenergic pathways in nonfailing and failing human ventricular myocardium, Circulation 82, 112.
6. Bristow, M.R.. W. Minobe, R. Rasmussen, P. Larrabee, L. Skerl, J. W. Klein, F.L. Anderson, J. Murray, L. Mestroni, S.V. Karwande and et al., 1992, Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms, J. Clin. Invest. 89, 803.
7. Brown, L.A. and S.E. Harding. 1992. The effect of pertussis toxin on β-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure, Br. J. Pharmacol. 106, 115.
8. Danielsen, W., H. von der Leyen, W. Meyer, J. Neumann, W. Schmitz, H. Scholz, J. Starbatty, B. Stein, V. Doring and P. Kalmar, 1989, Basal and isoprenaline-stimulated cAMP content in failing versus nonfailing human cardiac preparations, J. Cardiovasc. Pharmacol. 14, 171.
9. Davies, C.H., K. Davia, J. G. Bennett, J. R. Pepper, P.A. Poole-Wilson and S.E. Harding, 1995, Reduced contraction and altered frequency response of isolated ventricular myocytes from patients with heart failure. Circulation 92, 2540.
10. 2-adrenoceptors in single myocytes from human ventricle. Circulation 88, 854.
11. Del Monte, F.. P. O'Gara, P.A. Poole-Wilson, M.H. Yacoub and S.E. Harding, 1995. Cell geometry and contractile abnormalities of myocytes from failing human left ventricle. Cardiovasc. Res. 30, 281.
12. Eschenhagen, T., U. Mende, M. Nose, W. Schmitz, H. Scholz, A. Warnholtz and J.M. Wustel, 1991a. Isoprenaline-induced increase in mRNA levels of inhibitory G-protein alpha-subunits in rat heart, Naunyn-Schmiedeberg's Arch. Pharmacol. 343, 609.
13. Eschenhagen. T.. U. Mende, W. Schmitz, H. Scholz, J. Schulte am Esch. R. Sempell, A. Warnholtz and J. M. Wustel, 1991b. Beta-adrenoceptor stimulation-induced increase in cardiac Gi-protein expression and in carbachol sensitivity. Eur. Heart J. 12 (Suppl. F), 127.
14. Feldman, A.M., A.E. Cates, W.B. Veazey, R.E. Hershberger, M.R. Bristow. K.L. Baughman, W.A. Baumgartner and C. Van Dop, 1988a, Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart, J. Clin. Invest. 82, 189.
15. Feldman, M.D., J.D. Alderman, J.M. Aroesty, J.J. Ferguson, R.M. Owen, W. Grossman and R.G. McKay, 1988b, Depression of systolic and diastolic myocardial reserve during atrial pacing tachycardia in patients with dilated cardiomyopathy, J. Clin. Invest. 82, 1661.
16. Harding, S.E., G. Vescovo, M. Kirby, S.M. Jones, J. Gurden and P.A. Poole-Wilson, 1988. Contractile responses of isolated rat and rabbit myocytes to isoproterenol and calcium. J. Mol. Cell. Cardiol. 20, 635.
17. Harding. S.E., S.M. Jones. G. Vescovo, F. Del Monte and P.A. Poole-Wilson, 1992, Reduced contractile responses to forskolin and a cyclic AMP analogue in myocytes from failing human ventricle, Eur. J. Pharmacol. 223, 39.
18. Harding, S.E., E.A. Brown, F. Del Monte, P. O'Gara, D.G. Wynne and P.A. Poole-Wilson, 1993. Parallel changes in the β-adrenoceptor/adenylyl cyclase system between the failing human heart and the noradrenaline-treated guinea-pig, in: The Cardiomyopathic Heart, eds. M. Nagano, N. Takeda and N.S. Dhalla (Raven Press, New York).
19. Harding, S.E., L.A. Brown, D.G. Wynne, C.H. Davies and P.A. Poole-Wilson, 1994, Mechanisms of beta-adrenoceptor desensitisation in the failing human heart, Cardiovasc. Res. 28, 1451.
20. Harding, S.E., L.A. Brown, F. Del Monte, C.H. Davies, P. O'Gara, G. Vescovo, D.G. Wynne and P.A. Poole-Wilson, 1996, Acceleration of contraction by β-adrenoceptor stimulation is greater in ventricular myocytes from failing than non-failing human hearts. Basic Res. Cardiol. 92 (Suppl. 2), in press.
21. Hasenfuss, G., C. Holubarsch, H.P. Hermann, K. Astheimer, B. Pieske and H. Just, 1994, Influence of the force-frequency relationship on haemodynamics and left ventricular function in patients with non-failing hearts and in patients with dilated cardiomyopathy, Eur. Heart J. 15, 164.
22. Kaumann, A.J. , H. Lemoine, U. Schwederski Menke and B. Ehle, 1989. Relations between beta-adrenoceptor occupancy and increases of contractile force and adenylate cyclase activity induced by catecholamines in human ventricular myocardium. Acute desensitization and comparison with feline ventricle, Naunyn-Schmiedeberg's Arch. Pharmacol. 339, 99.
23. Kompa, A.R., P. Molenaar and R.J. Summers, 1992, Regulation of guinea-pig cardiac β-adrenoceptor subtypes after ( - )-adrenaline and ( - )-noradrenaline treatment. Mol. Neuropharmacol. 1, 203.
24. Maisch, B., 1981. Enrichment of vital adult cardiac muscle cells by contiuous silica sol gradient centrifugation. Basic Res. Cardiol. 76, 622.
25. Mann, D.L. and G. Cooper, 1989, Neurohumoral activation in congestive heart failure: a double-edged sword? Clin. Cardiol. 12, 485.
26. Mewes, T., S. Dutz. U. Ravens and K.H. Jakobs, 1993. Activation of calcium currents in cardiac myocytes by empty beta-adrenoceptors. Circulation 88, 2916.
27. Milano, C.A., L.F. Allen, P.C. Dolber, T.D, Johnson, H.A. Rockman, R.A. Bond and R.J. Lefkowitz, 1995, Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene, J, Thor. Cardiovasc. Surg. 109, 236.
28. Molenaar, P., J.J. Smolich, F.D. Russell, L.R. McMartin and R.J. Summers, 1990, Differential regulation of beta-1 and beta-2 adrenoceptors in guinea pig atrioventricular conducting system after chronic ( - )-isoproterenol infusion, J. Pharmacol. Exp. Ther. 255, 393.
29. Mulieri, L.A., G. Hasenfuss, B.J. Leavitt, P.D. Allen and N.R. Alpert, 1992, Altered myocardial force-frequency relation in human heart failure. Circulation 85, 1743.
30. 1 alpha-2 in rat heart. Circ. Res. 72, 696.
31. Naqvi, R.U., F. Del Monte, P. O'Gara, S.E. Harding and K.T. MacLeod, 1994, Characteristics of myocytes isolated from the hearts of renovascular hypertensive guinea-pigs, Am. J. Physiol. 266, H1886.
32. Raum, W.J. , M.M. Laks, D. Garner and R.S. Swerdloff, 1983, β-Adrenergic receptor and cyclic AMP alterations in the canine ventricle septum during long-term noradrenaline infusion: implications for hypertrophic cardiomyopathy, Lab. Invest. 68, 693.
33. Regitz-Zagrosek, V., R. Hertrampf, C. Steffen, A. Hidebrandt and E. Fleck, 1994, Myocardial cyclic AMP and norepinephrine content in human heart failure, Eur. Heart J. 15D, 7.
34. Reithmann, C. and K. Werdan, 1989, Noradrenaline-induced desensitization in cultured heart cells as a model for the defects of the adenylate cyclase system in severe heart failure, Naunyn-Schmiedeberg's Arch. Pharmacol. 339, 138.
35. Reithmann, C., P. Gierschik, D. Sidiropoulos, K. Werdan and K.H. Jakobs, 1989, Mechanism of noradrenaline-induced heterologous desensitisation of adenylate cyclase stimulation in rat heart muscle cells: increase in the level of inhibitory G-protein alpha-subunits, Eur. J. Pharmacol. 172, 211.
36. Schwinger, R.H.G., M. Bohm, J. Muller-Ehmsen, R. Uhlmann, U. Schmidt, A. Stablein, P. Uberfuhr, E. Kreuzer, B. Reichart, H-J. Eissner and E. Erdmann, 1993, Effect of inotropic stimulation on the negative force-frequency relationship in the failing human heart, Circulation 88, 2267.
37. Souffer, R., D. Wohlgelernter, N.A. Vita, M. Amuchestegui, H.D. Sostman, H. Berger and B. Zaret, 1985, Intact systolic left ventricular function in clinical congestive heart failure. Am. J. Cardiol, 55, 1032.
38. von der Leyen, H., U. Mende, W. Meyer, J. Neumann, M. Nose, W. Schmitz, H. Scholz, J. Starbatty, B. Stein, H. Wenzlaff, V. Doring, P. Kalmar and A. Haverich, 1991, Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to non-failing human cardiac muscle preparations, Naunyn-Schmiedeberg's Arch. Pharmacol. 344, 90.
39. Waagstein, F., M.R. Bristow, K. Swedberg, F. Camerini, M.B. Fowler, M.A. Silver, E.M. Gilbert, M.R. Johnson, F.G. Goss and A. Hjalmarson, 1993, Beneficial effects of metoprolol in idiopathic dilated cardimyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group, Lancet 342, 1441.
40. Wheatley, A.M., F.T. Thandroyen and L.H. Opie, 1985, Catecholamine-induced myocardial cell damage: catecholamines or adrenochrome, J Mol, Cell. Cardiol. 17, 349.
41. Wynne, D.G., P.A. Poole-Wilson and S.E. Harding, 1993, Incomplete reversal of β-adrenoceptor desensitisation by cyclic nucleotide phosphodiesterase inhibition in isolated cardiac myocytes from patients with cardiac failure and noradrenaline-treated guinea-pigs, Br. J. Pharmacol. 109, 1071.