Inhibitors of the protease domain of urokinase-type plasminogen activator

Current Pharmaceutical Design

Volumn 8, Issue 28, 2002, Pages 2541-2558

  Rockway, T W ^a   Nienaber, V ^a   Giranda, V L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOMETHYLBENZOIC ACID; AMILORIDE; AMINO ACID DERIVATIVE; AMINOCAPROIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; BENZAMIDINE DERIVATIVE; BENZOTHIOPHENE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CATHEPSIN; COUMARIN DERIVATIVE; ENZYME INHIBITOR; ENZYME PRECURSOR; GLYCOSYLPHOSPHATIDYLINOSITOL; GUANIDINE DERIVATIVE; HEXANOIC ACID DERIVATIVE; HEXAPEPTIDE; ISOQUINOLINE DERIVATIVE; LEUPEPTIN; PLASMA KALLIKREIN; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; TRANEXAMIC ACID; TRYPSIN; TRYPSIN INHIBITOR; UNINDEXED DRUG; UROKINASE; UROKINASE RECEPTOR;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; CANCER GROWTH; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; DISEASE COURSE; DRUG DESIGN; DRUG HALF LIFE; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; IC 50; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTERACTION; REVIEW; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; HUMANS; MODELS, MOLECULAR; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; URINARY PLASMINOGEN ACTIVATOR;

EID: 0036431989     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612023392676     Document Type: Review

References (95)

1. Duffy, M. J. Blood Coagulation Fibrinolysis, 1990, 1, 681.
2. Behrendt, N., Ronne, E., Ploug, M., Petri, T., Leber, D. J. Biol. Chem., 1990, 265, 6453.
3. Schmitt, M., Wilhelm, O., Janicke, F., Magdolen, V., Reuning, U. J. Obstetrics Gynaecology, 1995, 21, 151.
4. Schmitt, M., Janicke, F., Moniwa, N., Chucholowski, N., Pache, L. Biological Chemistry Hoppe-Seyler, 1992, 373, 611.
5. Andreasen, P. A., Kjoller, L., Christensen, L., Duffy, M. J. Int. J. Cancer, 1997, 72, 1.
6. Dano, K., Andreasen, P. A., Grondahl-Hansen, J., Kristensen, P., Nielsen, L. S. Adv. Cancer Res., 1985, 44, 139.
7. Kobayashi, H., Schmitt, M., Goretzki, L., Chucholowski, N., Calvete, J. J. Biol. Chem., 1991, 266, 5147.
8. Koivunen, E., Huhtala, M. L., Stenman, U.H. J. Biol. Chem., 1989, 264, 14095.
9. Stack, M. S., Johnson, D. A. J. Biol. Chem., 1994, 269, 9416.
10. Vassalli, J. D., Baccino, D., Belin, D. J. Cell Biol., 1985, 100, 86.
11. Stoppelli, M. P., Corti, A., Soffientini, A., Cassani, G., Blasi, F. Proc. Nat. Acad Sci. USA, 1985, 82, 4939.
12. Mondino, A., Resnati, M., Blasi, F. Thrombosis Haemostasis, 1999, 82, 19.
13. Pyke, C., Kristensen, P., Ralfkiaer, E., Grondahl-Hansen, J., Eriksen, J. Amer. J. Pathology, 1991, 138, 1059.
14. Christensen, L., Wiborg Simonsen, A. C., Heegaard, C. W., Moestrup, S. K., Andersen, J. A. Int. J. Cancer, 1996, 66, 441.
15. Nielsen, B. S., Sehested, M., Timshel, S., Pyke, C., Dano, K Laboratory Investigation, 1996, 74, 168.
16. Pyke, C., Graem, N., Ralfkiaer, E., Ronne, E., Hoyer-Hansen, G. Cancer Res., 1993, 53, 1911.
17. Parolini, S., Flagiello, D., Cinquetti, A., Gozzi, R., Cristini, S. British J. Cancer, 1996, 74, 1168.
18. Sandstrom, M., Johansson, M., Sandstrom, J., Bergenheim, A. T., Henriksson, R. Int. J. Developmental Neuroscience, 1999, 17, 473.
19. Morita, S., Sato, A., Hayakawa, H., Ihara, H., Urano, T. Int. J. Cancer, 1998, 78, 286.
20. Bolon, I., Devouassoux, M., Robert, C., Moro, D., Brambilla, C. Amer. J. Pathology, 1997, 150, 1619.
21. Gladson, C. L., Pijuan-Thompson, V., Olman, M. A., Gillespie, G. Y., Yacoub, I. Z. Amer. J. Pathology, 1995, 146, 1150.
22. Yamamoto, M., Sawaya, R., Mohanam, S., Bindal, A. K., Bruner, J. M. Cancer Res., 1994, 54, 3656.
23. Sappino, A. P., Belin, D., Huarte, J., Hirschel-Scholz, S., Saurat, J. H. J. Clin. Investigation, 1991, 88, 1073.
24. Degryse, B., Orlando, S., Resnati, M., Rabbani, S. A., Blasi, F. Oncogene, 2001, 20, 2032.
25. Yebra, M., Parry, G. C. N., Stromblad, S., Mackman, N., Rosenberg, S. J. Biol. Chem., 1996, 271, 29393.
26. Yebra, M., Goretzki, L., Pfeifer, M., Mueller, B. M. Exp. Cell Res., 1999, 2505 231.
27. Simon, D. I, Wei, Y., Zhang, L., Rao, N. K., Xu, H. J. Biol. Chem., 2000, 275, 10228.
28. Tarui, T., Mazar, A. P., Cines, D. B., Takada, Y. J. Biol. Chem., 2001, 276, 3983.
29. Ossowski, L., Aguirre-Ghiso, J. A. Curr. Opin. Cell Biol., 2000, 12, 613.
30. Blasi, F. Thrombosis Haemostasis, 1999, 82, 298.
31. Dano, K., Romer, J., Nielsen, B. S., Bjorn, S., Pyke, C. APMIS, 1999, 107, 120.
32. Johnsen, M., Lund, L. R., Romer, J., Almholt, K., Dano, K Curr. Opin. Cell Biol., 1998, 10, 667.
33. Carmeliet, P., Moons, L., Lijnen, R., Baes, M., Lemaitre, V. Nature Genetics, 1997, 17, 439.
34. Falkenberg, M., Giglio, D., Bjornheden, T., Nygren, H., Risberg, B. J. Vascular Res., 1998, 35, 318.
35. Lupu, F., Heim, D. A., Bachmann, F., Hurni, M., Kakkar, V. V. Arteriosclerosis, Thrombosis Vascular Biology, 1995, 15, 1444.
36. Noda-Heiny, H., Daugherty, A., Sobel, B. E. Arteriosclerosis, Thrombosis Vascular Biology, 1995, 15,37.
37. Caccamo, D. V., Keohane, M. E., McKeever, P. E. P Modern Pathology, 1994, 7, 99.
38. Christ, G., Kostner, K., Zehetgruber, M., Binder, B. R., Gulba, D. J. Thrombosis Thrombolysis, 1999, 7, 277.
39. Kanse, S. M., Benzakour, O., Kanthou, C., Kost, C., Lijnen, H. R. Arteriosclerosis, Thrombosis Vascular Biology, 1997, 17, 2848.
40. Del Rosso, M., Fibbi, G., Matucci Cerinic, M. Clin. Exp. Rheumatology, 1999, 17, 485.
41. Busso, N., Peclat, V., Van Ness, K., Kolodziesczyk, E., Degen, J. J. Clin. Investigation, 1998, 102, 41.
42. Medcalf, R. L., Hamilton, J. A. Arthritis Rheumatism, 1986, 29, 1397.
43. Koolwijk, P., Miltenburg, A. M., van Erck. M. G., Oudshoorn, M., Niedbala, M. J. J. Rheumatology, 1995, 22, 385.
44. Heymans, S., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E. Nature Medicine, 1999, 5, 1135.
45. Das, A., McGuire, P. G., Eriqat, C., Ober, R. R., DeJuan, E., Jr. Investigative Ophthalmology Visual Science, 1999, 40, 809.
46. Duffy, M. J., Maguire, T. M., McDermott, E. W., O'Higgins, N. J. Surgical Oncology, 1999, 71, 130.
47. Bugge, T. H., Lund, L. R., Kombrinck, K. K., Nielsen, B. S., Holmback, K. Oncogene, 1998, 16, 3097.
48. Shapiro, R. L., Duquette, J. G., Roses, D. F., Nunes, I., Harris, M. N. Cancer Res., 1996, 56, 3597.
49. Lund, L. R., Romer, J., Bugge, T. H., Nielsen, B. S., Frandsen, T. L. EMBO J., 1999, 18, 4645.
50. Ignar, D. M., Andrews, J. L., Witherspoon, S. M., Leray, J. D., Clay, W. C. Clin. Exp. Metastasis, 1998, 16,9.
51. Tressler, R. T., Pitot, P. A., Stratton, J. R., Forrest, L. D., Zhuo, S. APMIS, 1999, 107, 168-173.
52. Kawazoe, Y., Sawada, T., Chung, Y.-S., Sowa, M Int. J Oncology, 1997, 10, 983.
53. Jankun, J., Keck, R., Skrzypczak-Jankun, E., Swiercz, R. Cancer Res., 1997, 57, 559.
54. Evans, D., Sloan-Stakleff, K., Arvan, M., Guyton, D. Clin. Exp. Metastasis, 1998, 16, 353.
55. Xing, R. H., Mazar, A., Henkin, J., Rabbani, S. Cancer Res., 1997, 57, 3585.
56. Alonso, D. F., Tejera, A. M., Farias, E. F., Bal de Kier Joffe, E., Gomez, D. E. Anticancer Res., 1998, 18, 4499.
57. Alonso, D. F., Farias, E. F., Ladeda, V., Davel, L., Puricelli, L. Breast Cancer Res. Treatment, 1996, 40, 209.
58. Rabbani, S. A., Harakidas, P., Davidson, D. J., Henkin, J., Mazar, A. P. Int. J. Cancer, 1995, 63, 840.
59. Pilat, M. J., Lehr, J. E., Quigley, M. M., Pienta, K. J. Oncology Reports, 1998, 5, 889.
60. Foekens, J. A., Buessecker, F., Peters, H. A., Krainick, U., van Putten, W. L. Cancer Res., 1995, 55, 1423.
61. Umeda, T., Eguchi, Y., Okino, K., Kodama, M., Hattori, T. J. Pathology, 1997, 183, 388.
62. Reuning, U., Magdolen, V., Wilhelm, O., Fischer, K., Lutz, V. Int. J. Oncology, 1998, 13, 893.
63. Bajou, K., Masson, V., Gerard, R. D., Schmitt, P. M., Albert, V. J. Cell Biology, 2001, 152, 777.
64. Spraggon, G., Phillips, C., Nowak, U. K., Ponting, C. P., Saunders, D. Structure, 1995, 3, 681.
65. Nienaber, V. L., Davidson, D., Edalji, R., Giranda, V. L., Klinghofer, V. Structure, 2000, 8, 553.
66. Katz, B. A., Mackman, R., Luong, C., Radika, K., Martelli, A. Chem. Biol., 2000, 7,299.
67. Lorand, L., Condit, E. V. Biochemistry, 1965, 4, 265.
68. Walton, P. L. Biochimica Biophysica Acta, 1967, 132, 104.
69. Ong, E. B., Johnson, A. J., Schoellmann, G. Biochimica Biophysica Acta, 1976, 429, 252.
70. Westlund, L. E., Lunden, R., Wallen, P. Haemostasis, 1982, 11, 235.
71. Christova, E., Yomtova, V., Blagoev, B. Int. J. Pep. Prot. Res., 1980, 15, 459
72. Menegatti, E., Guarneri, M., Bolognesi, M., Ascenzi, P., Amiconi, G. J. Enzyme Inhibition, 1989, 2, 249.
73. Wakselman, M., Xie, J., Mazaleyrat, J.-P., Boggetto, A.-C., Montagne, J.-J. J. Med. Chem., 1993, 36, 1539.
74. Bechet, J. J., Dupaix, A., Roucous, C., Bonamy, A.-M. Biochimie, 1977, 59, 241.
75. Kawada, M., Umezawa, K. Biochem. Biophys. Res. Comm., 1995, 209, 25.
76. Ke, S. H., Coombs, G. S., Tachias, K., Corey, D. R., Madison, E. L. J. Biol. Chem., 1997, 272, 20456.
77. Tamura, S. Y., Weinhouse, M. I., Roberts, C. A., Goldman, E. A., Masukawa, K. Bioorg. Med Chem. Lett., 2000, 109, 983.
78. Yang, H., Henkin, J., Kim, K. H., Greer, J. J. Med Chem., 1990, 33, 2956.
79. Sperl, S., Jacob, U., Arroyo de Prada, N., Sturzebecher, J., Wilhelm, O., Bode, W., Magdolen, V., Huber, R., Moroder, L. Proc. Nat. Acad Sci. USA, 2000, 97, 5113.
80. Vassalli, J. D., Belin, D. FEBS Lett., 1987, 214, 187.
81. Menear, K. Curr. Med. Chem., 1998, 5, 457.
82. Towle, M. J., Lee, A., Maduakor, E, C., Schwartz, C. E., Bridges, A. J. Cancer Res., 1993, 53, 2553.
83. Bridges, A. J., Lee, A., Schwartz, C. E., Towle, M. J., Littlefield, B. A. Bioorg. Med. Chem., 1993, 1, 403.
84. Bridges, A. L., B. A., Schwartz, C.E. US 5340833, Eisai Co., Ltd., Tokyo, Japan, 1994.
85. Dellaria, J. Abbott Laboratories: US 6207701, 2001.
86. Sturzebecher, J., Markwardt, F. Pharmazie, 1978, 33, 599.
87. Menegatti, E., Ferroni, R., Nastruzzi, C., Bortolotti, F., Scalia, S., Amiconi, G. Farmaco, 1991, 46, 1297.
88. Odagki, Y., Nakai, H., Senokuchi, K., Kawamura, M., Hamanaka, N. Biochemistry, 1995, 34, 12849.
89. Sturzebecher, J., Vieweg, H., Steinmetzer, T., Schweinitz, A., Stubbs, M. T. Bioorg. Med Chem, Lett., 1999, 9, 3147.
90. Zeslawska, E., Schweinitz, A., Karcher, A., Sondermann, P., Sperl, S., Sturzebecher, J., Jacob, U. J. Mol. Biol., 2000, 301, 465.
91. Pfizer, I. In US patent 6093731, 2000,
92. Pfizer, I. In EP patent 1044967A2, 2000.
93. Hajduk, P. J., Boyd, S., Nettesheim, D., Nienaber, V., Severin, J.J. Med Chem., 2000, 43, 3862.
94. Nienaber, V. L., Richardson, P. L., Klighofer, V., Bouska, J. J., Giranda, V. L. Nature Biotechnol., 2000, 18, 1105.
95. Tidwell, R. R., Geratz, J. D., Dubovi, E. J. J. Med. Chem., 1983, 26, 294.