Epigenetic modifiers exert renal toxicity through induction of p66shc

Anticancer Research

Volumn 31, Issue 10, 2011, Pages 3267-3271

  Arany, Istvan ^a   Clark, Jeb S ^a   Ember, Istvan ^b   Juncos, Luis A ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Epigenetic modifiers; Kidney; Mitochondria; P66shc; ROS; Toxicity

Indexed keywords

AZACITIDINE; CYTOCHROME C; PROTEIN P66; REACTIVE OXYGEN METABOLITE; TRICHOSTATIN A;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL ISOLATION; CONTROLLED STUDY; EPIGENETICS; KIDNEY PROXIMAL TUBULE; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

ANIMALS; AZACITIDINE; BINDING SITES; CELL LINE, TRANSFORMED; CYTOCHROMES C; EPIGENESIS, GENETIC; GENE KNOCKDOWN TECHNIQUES; HYDROXAMIC ACIDS; KIDNEY TUBULES, PROXIMAL; MICE; MITOCHONDRIA; MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; SHC SIGNALING ADAPTOR PROTEINS; UP-REGULATION;

EID: 80054743481     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Sigalotti L, Fratta E, Coral S, Cortini E, Covre A, Nicolay HJ, Anzalone L, Pezzani L, Di Giacomo AM, Fonsatti E, Colizzi F, Altomonte M, Calabro L and Maio M: Epigenetic drugs as pleiotropic agents in cancer treatment: biomolecular aspects and clinical applications. J Cell Physiol 212: 330-344, 2007. (Pubitemid 47025622)
2. Peterson BA, Collins AJ, Vogelzang NJ and Bloomfield CD: 5-Azacytidine and renal tubular dysfunction. Blood 57: 182-185, 1981. (Pubitemid 11188889)
3. Peterson BA, Bloomfield CD, Gottlieb AJ, Coleman M and Greenberg MS: 5-Azacytidine and zorubicin for patients with previously treated acute nonlymphocytic leukemia: a Cancer and Leukemia Group B pilot study. Cancer Treat Rep 66: 563-566, 1982. (Pubitemid 12084954)
4. Kintzel PE: Anticancer drug-induced kidney disorders. Drug Saf 24: 19-38, 2001.
5. Gao S, Mobley A, Miller C, Boklan J and Chandra J: Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells. Leuk Res 32: 771-780, 2008. (Pubitemid 351323931)
6. Xu WS, Parmigiani RB and Marks PA: Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26: 5541-5552, 2007. (Pubitemid 47255934)
7. Nadasi E, Clark JS, Szanyi I, Varjas T, Ember I, Baliga R and Arany I: Epigenetic modifiers exacerbate oxidative stress in renal proximal tubule cells. Anticancer Res 29: 2295-2299, 2009.
8. Pellegrini M, Pacini S and Baldari CT: p66SHC: the apoptotic side of Shc proteins. Apoptosis 10: 13-18, 2005. (Pubitemid 40558111)
9. Arany I, Faisal A, Clark JS, Vera T, Baliga R and Nagamine Y: p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury. Am J Physiol Renal Physiol 298: F1214-F1221, 2010.
10. Arany I, Faisal A, Nagamine Y and Safirstein RL: p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells. J Biol Chem 283: 6110-6117, 2008.
11. Ventura A, Luzi L, Pacini S, Baldari CT and Pelicci PG: The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. J Biol Chem 277: 22370-22376, 2002. (Pubitemid 34967205)
12. Ernest S and Bello-Reuss E: Expression and function of P-glycoprotein in a mouse kidney cell line. Am J Physiol 269: C323-333, 1995.
13. 2 cytotoxicity in mouse renal proximal tubule cells. Kidney Int 65: 1231-1239, 2004.
14. Kim CS, Jung SB, Naqvi A, Hoffman TA, DeRicco J, Yamamori T, Cole MP, Jeon BH and Irani K: p53 impairs endothelium-dependent vasomotor function through transcriptional up regulation of p66shc. Circ Res 103: 1441-1450, 2008.
15. Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C, Pelliccia G, Luzi L, Minucci S, Marcaccio M, Pinton P, Rizzuto R, Bernardi P, Paolucci F and Pelicci PG: Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122: 221-233, 2005. (Pubitemid 41032986)
16. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M and Pelicci PG: The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans membrane potential. J Biol Chem 279: 25689-25695, 2004. (Pubitemid 38756832)
17. Arany I, Herbert J, Herbert Z and Safirstein RL: Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. Am J Physiol Renal Physiol 294: F577-581, 2008. (Pubitemid 351442228)
18. Dong G, Luo J, Kumar V and Dong Z: Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. Am J Physiol Renal Physiol 298: F293-300, 2010.
19. Dong G, Wang L, Wang CY, Yang T, Kumar MV and Dong Z: Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents. J Pharmacol Exp Ther 325: 978-984, 2008. (Pubitemid 351724333)
20. Droge W: Free Radicals in the Physiological Control of Cell Function. Physiol Rev 82: 47-95, 2002.