The effect of intraoperative blood loss on serum cefazolin level in patients undergoing instrumented spinal fusion: A prospective, controlled study

Spine

Volumn 21, Issue 20, 1996, Pages 2363-2367

  Polly Jr , David W ^a   Meter, Jeffrey J ^a   Brueckner, Ralf ^b   Asplund, Lynn ^a   Van Dam, Bruce E ^c  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c SCRIPPS MEMORIAL HOSPITAL   (United States)

Author keywords

blood loss; cefazolin; pharmacokinetics; spine fusion

Indexed keywords

CEFAZOLIN; CREATININE;

ADOLESCENT; ADULT; AGED; ARTICLE; BLEEDING; CLINICAL ARTICLE; CLINICAL TRIAL; CREATININE CLEARANCE; DRUG BLOOD LEVEL; DRUG CLEARANCE; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; OSTEOSYNTHESIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPINE FUSION;

ADOLESCENT; ADULT; AGED; BLOOD LOSS, SURGICAL; CEFAZOLIN; CEPHALOSPORINS; CREATININE; FEMALE; HUMANS; INFECTION CONTROL; INTRAOPERATIVE COMPLICATIONS; MALE; MIDDLE AGED; SPINAL FUSION;

EID: 10244228006     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199610150-00011     Document Type: Article

References (32)

1. Anderson LD, Mayer FN. Management of infected implants. In: Chapman MW, ed. Operative Orthopaedics. Philadelphia: JB Lippincott, 1988:875-84.
2. Bradford DS. The Pediatric Spine. New York: Thieme, 1985:434-47.
3. Brawley RL. Surgical wound infection. In: Donowitz LG, ed. Hospital Acquired Infections in the Pediatric Patient. Baltimore: Williams & Wilkins, 1988:47-55.
4. Chang CC, Merritt K. Infection at the site of implanted materials with and without preadhered bacteria. J Orthop Res 1994;12:526-31.
5. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
6. Colaizzi PA, Goodwin SD, Poyner WJ, Karnes HT, Polk RE. Single dose pharmacokinetics of cefuroxime and cefamandole in healthy subjects. Clin Pharm 1987;6:894-9.
7. Cunha BA, Gossling HR, Pasternak HS, Nightingale CH, Quintiliani R. The penetration characteristics of cefazolin, cephalothin, and cephradine into bone in patients undergoing total hip replacement. J Bone Joint Surg [Am] 1977;59:856-9.
8. Fitzgerald RH, Washington JA. Contamination of the operative wound. Orthop Clin North Am 1975;6:1105-14.
9. Fitzgerald RH, Thompson RL. Cephalosporin antibiotics in the prevention and treatment of musculoskeletal sepsis. J Bone Joint Surg [Am] 1983;65:1201-5.
10. Gibaldi M, Perrier D. Pharmacokinetics. New York: Marcel Dekker, 1982.
11. Golper TA, Noonan HM, Elzing L, et al. Vancomycin pharmacokinetics, renal-handling, and non-renal clearances in normal human subjects. Clin Pharmacol Ther 1988;43:565-70.
12. Gristina AG, Costerton JW. Bacterial adherence to biomaterials and tissue: The significance of its role in clinical sepsis. J Bone Joint Surg [Am] 1985;67:264-73.
13. Gristina AG, Costerton JW. Bacterial adherence and the glycocalx and their role in musculoskeletal infection. Orthop Clin North Am 1984;15:517-35.
14. Guglielmo BJ, Salazar TA, Rodondi LC, Carver M, Goldstone J, Stoney RJ. Altered pharmacokinetics of antibiotics during vascular surgery. AmJ Surg 1989;157:410-2.
15. Holford N. MKMODEL. Version 4. Milltown, New Jersey: Biosoft, 1990.
16. Keller RB, Pappas AM. Infection after spinal fusion using internal fixation instrumentation. Orthop Clin North Am 1972;3:99-111.
17. Kloth DD, Tegtmeier CK, Akahoshi MP, Leach SH, Beatty JD, Zaia JA. Altered gentamicin pharmacokinetics during the perioperative period. Clin Pharm 1985;4:182-5.
18. Lonstein JE. Complications of treatment. In: Bradford DS, Lonstein JE, Moe JH, Ogilvie JW, Winter RB, eds. Moe's Textbook of Scoliosis and Other Spinal Deformities. 2nd ed. Philadelphia: WB Saunders, 1987:456-90.
19. Lopez-Sosa FH, Polly D, Bowen JR, et al. Serum cefazolin levels during spinal fusion: Effect of blood loss and duration of surgery. J Spinal Disord 1993;6:296-9.
20. Mader JT, Cierny G. The principles of the use of preventive antibiotics. Clin Orthop 1984;190:75-82.
21. Moe JH. Complications of scoliosis treatment. Clin Orthop 1967;53:21-30.
22. Nelson CL, Bergfeld JA, Schwartz J, Kolczun M. Antibiotics in human hematoma and wound fluid. Clin Orthop 1975; 108:138-44.
23. Neu HC. Cephalosporin antibiotics as applied in surgery of bones and joints. Clin Orthop 1984;190:50-64.
24. Ritter MA, Stringer EA, Williams J, Carlson S. The effect of hypotensive anesthesia on cephalosporin concentrations in serum, soft tissue, and bone. Clin Orthop 1983;175:218-22.
25. Schentag JJ, Jusko WJ, Vance JW, et al. Gentamycin disposition and tissue accumulation on multiple dosing. J Pharmacokinet Biopharm 1977;5:559-77.
26. Schurman DJ, Hirshman HP, Kajiyama G, Moser K, Burton DS. Cefazolin concentrations in bone and synovial fluid. J Bone Joint Surg [Am] 1978;60:359-62.
27. Schutzer SF, Harris WH. Deep-wound infection after total hip replacement under contemporary aseptic conditions. J Bone Joint Surg [Am] 1988;70:724-7.
28. Shanks CA, Avram MJ, Ronai AK, Bowsher DJ. The pharmacokinetics of d-tubocurarine with surgery involving salvaged autologous blood. Anesthesiology 1985;62:161-5.
29. Sue D, Salazar TA, Turley K, Guglielmo BJ. Effect of surgical blood loss and volume replacement on antibiotic pharmacokinetics. Ann Thorac Surg 1989;47:857-9.
30. Welch WD, Jantzen JP, Johnson K, Bawdon RE. Effects of general and local anesthesia on the pharmacokinetics of cefazolin in patients undergoing orthopedic surgery. Antimicrob Agents Chemother 1985;27:874-5.
31. Wiggins CE, Nelson CL, Clarke R, Thompson CH. Concentration of antibiotics in normal bone after intravenous injection. J Bone Joint Surg [Am] 1978;60:93-6.
32. Williams DN, Gustilo RB, Beverly R, Kind AC. Bone and serum concentrations of five cephalosporin drugs. Clin Orthop 1983;179:253-5.