Precision Manufacture of Phase-Change Perfluorocarbon Droplets Using Microfluidics

Ultrasound in Medicine and Biology

Volumn 37, Issue 11, 2011, Pages 1952-1957

  Martz, Thomas D ^a   Sheeran, Paul S ^b   Bardin, David ^c   Lee, Abraham P ^c   Dayton, Paul A ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b USA and North Carolina State University   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acoustic droplet vaporization; Microfluidic; Monodisperse; Perfluoropentane; Ultrasound

Indexed keywords

FAT DROPLET; PERFLUOROPENTANE;

ACOUSTICS; DISPERSION; MICROFLUIDICS; MOLECULAR SIZE; MOLECULAR STABILITY; NOTE; PHASE TRANSITION; PRESSURE; PRIORITY JOURNAL; SYNTHESIS; ULTRASOUND; VAPORIZATION;

EID: 80054740899     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2011.08.012     Document Type: Article

References (29)

1. Apfel R.E. Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis United States 1998, Apfel Enterprises, Inc., New Haven, CT.
2. Fabiilli M.L., Lee J.A., Kripfgans O.D., Carson P.L., Fowlkes J.B. Delivery of water-soluble drugs using acoustically triggered perfluorocarbon double emulsions. Pharm Res 2010, 27:2753-2765.
3. Fabiilli M.L., Haworth K.J., Fakhri N.H., Kripfgans O.D., Carson P.L., Fowlkes J.B. The role of inertial cavitation in acoustic droplet vaporization. IEE Trans Ultrason Ferroelectr Freq Control 2009, 56:1006-1017.
4. Giesecke T., Hynynen K. Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro. Ultrasound Med Biol 2003, 29:1359-1365.
5. Haworth K.J., Fowlkes J.B., Carson P.L., Kripfgans O.D. Towards aberration correction of transcranial ultrasound using acoustic droplet vaporization. Ultrasound Med Biol 2008, 34:435-445.
6. Hettiarachchi K., Talu E., Longo M.L., Dayton P.A., Lee A.P. On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging. Lab Chip 2007, 7:463-468.
7. Hettiarachchi K., Zhang S., Feingold S., Lee A.P., Dayton P.A. Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy. Biotechnol Prog 2009, 25:938-945.
8. Huh D., Bahng J.H., Ling Y., Wei H.H., Kripfgans O.D., Fowlkes J.B., Grotberg J.B., Takayama S. Gravity-driven microfluidic particle sorting device with hydrodynamic separation amplification. Anal Chem 2007, 79:1369-1376.
9. Kaya M., Feingold S., Hettiarachchi K., Lee A.P., Dayton P.A. Acoustic responses of monodisperse lipid-encapsulated microbubble contrast agents produced by flow focusing. Bubble Sci Eng Technol 2010, 2:33-40.
10. Kripfgans O.D., Fowlkes J.B., Woydt M., Eldevik O.P., Carson P.L. In vivo droplet vaporization for occlusion therapy and phase aberration correction. IEEE Trans Ultrason Ferroelectr Freq Control 2002, 49:726-738.
11. Kripfgans O.D., Orifici C.M., Carson P.L., Ives K.A., Eldevik O.P., Fowlkes J.B. Acoustic droplet vaporization for temporal and spatial control of tissue occlusion: A kidney study. IEEE Trans Ultrason Ferroelectr Freq Control 2005, 52:1101-1110.
12. Lo A.H., Kripfgans O.D., Carson P.L., Rothman E.D., Fowlkes J.B. Acoustic droplet vaporization threshold: Effects of pulse duration and contrast agent. IEEE Trans Ultrason Ferroelectr Freq Control 2007, 54:933-946.
13. Marsh J.N., Partlow K.C., Abendschein D.R., Scott M.J., Lanza G.M., Wickline S.A. Molecular imaging with targeted perfluorocarbon nanoparticles: Quantification of the concentration dependence of contrast enhancement for binding to sparse cellular epitopes. Ultrasound Med Biol 2007, 33:950-958.
14. Miller D.L., Averkiou M.A., Brayman A.A., Everbach E.C., Holland C.K., Wible J.H., Wu J. Bioeffects considerations for diagnostic ultrasound contrast agents. J Ultrasound Med 2008, 27:611-632. quiz 633-636.
15. Quay S.C. Phase shift colloids as ultrasound contrast agents United States 1996, Sonus Pharmaceuticals, Waltham, MA.
16. Rapoport N., Christensen D.A., Kennedy A.M., Nam K.H. Cavitation properties of block copolymer stabilized phase-shift nanoemulsions used as drug carriers. Ultrasound Med Biol 2010, 36:419-429.
17. Rapoport N.Y., Kennedy A.M., Shea J.E., Scaife C.L., Nam K.H. Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. J Control Release 2009, 138:268-276.
18. Rapoport N.Y., Efros A.L., Christensen D.A., Kennedy A.M., Nam K.H. Microbubble generation in phase-shift nanoemulsions used as anticancer drug carriers. Bubble Sci Eng Technol 2009, 1:31-39.
19. Rapoport N., Gao Z., Kennedy A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J Natl Cancer Inst 2007, 99:1095-1106.
20. Sheeran P.S., Wong V.P., Luois S., McFarland R.J., Ross W.D., Feingold S., Matsunaga T.O., Dayton P.A. Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasound imaging. Ultrasound Med Biol 2011, E-pub:1-13.
21. Tan Y.C., Fisher J.S., Lee A.I., Cristini V., Lee A.P. Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting. Lab Chip 2004, 4:292-298.
22. Tan Y.C., Lee A.P. Microfluidic separation of satellite droplets as the basis of a monodispersed micron and submicron emulsification system. Lab Chip 2005, 5:1178-1183.
23. Teh S.Y., Lin R., Hung L.H., Lee A.P. Droplet microfluidics. Lab Chip 2008, 8:198-220.
24. Wang W., Xie R., Ju X.J., Luo T., Liu L., Weitz D.A., Chu L.Y. Controllable microfluidic production of multicomponent multiple emulsions. Lab Chip 2011, 11:1587-1592.
25. Xu S., Nie Z., Seo M., Lewis P., Kumacheva E., Stone H.A., Garstecki P., Weibel D.B., Gitlin I., Whitesides G.M. Generation of monodisperse particles by using microfluidics: Control over size, shape, and composition. Angew Chem Int Ed Engl 2005, 44:724-728.
26. Xu J.H., Li S.W., Tan J., Wang Y.J., Luo G.S. Controllable preparation of monodisperse O/W and W/O emulsions in the same microfluidic device. Langmuir 2006, 22:7943-7946.
27. Zhang M., Fabiilli M.L., Haworth K.J., Fowlkes J.B., Kripfgans O.D., Roberts W.W., Ives K.A., Carson P.L. Initial investigation of acoustic droplet vaporization for occlusion in canine kidney. Ultrasound Med Biol 2010, 36:1691-1703.
28. Zhang P., Porter T. An in vitro study of a phase-shift nanoemulsion: A potential nucleation agent for bubble-enhanced HIFU tumor ablation. Ultrasound Med Biol 2010, 36:1856-1866.
29. Zhang M., Fabiilli M.L., Haworth K.J., Padilla F., Swanson S.D., Kripfgans O.D., Carson P.L., Fowlkes J.B. Acoustic droplet vaporization for enhancement of thermal ablation by high intensity focused ultrasound. Acad Radiol 2011, 18:1123-1132.