Genotype of the LMNA 1908C>T variant is associated with generalized obesity in Asian Indians in North India

Clinical Endocrinology

Volumn 75, Issue 5, 2011, Pages 642-649

  Sharma, Mukti ^a   Misra, Anoop ^b   Vikram, Naval ^c   Suryaprakash, Bhatt ^c   Chhabra, Shivani ^a   Garg, Neha ^a   Pandey, Ravindra Mohan ^a   Upadhyay, Ashish Datt ^a   Luthra, Kalpana ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b FORTIS HOSPITAL   (India)

^c All India of Medical Sciences   (India)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIN A;

ADULT; ARTICLE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INDIA; INDIAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDIA; LAMIN TYPE A; LOGISTIC MODELS; MALE; MIDDLE AGED; OBESITY; YOUNG ADULT;

EID: 80054739833     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2011.04111.x     Document Type: Article

References (34)

1. Wydner, K.L., McNeil, J.A., Lin, F., et al. (1996) Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1 AND LBR by fluorescence in situ hybridization. Genomics, 32, 474-478. (Pubitemid 26094354)
2. Lin, F., &, Worman, H.J., (1993) Structural organization of the human gene encoding lamin A and nuclear laminC. The Journal of Biological Chemistry, 268, 16321-16326. (Pubitemid 23229934)
3. Fisher, D.Z., Chaudhary, N., &, Blobel, G., (1986) cDNA sequencing of nuclear lamins A and C reveals primary and secondary structure between nuclear envelope and intermediate filament proteins. Proceedings of the National Academy of Sciences of the United States of America, 83, 6450-6454. (Pubitemid 17174752)
4. Gruenbaum, Y., Goldman, R.D., Meyuhas, R., et al. (2003) The nuclear lamina and its function in the nucleus. International Review of Cytology, 226, 1-62. (Pubitemid 36959354)
5. Clements, L., Manilal, S., Love, D.R., et al. (2000) Direct interaction between emerin and lamin A. Biochemical and Biophysical Research Communications, 267, 709-714. (Pubitemid 30099388)
6. Cohen, M., Lee, K.K., Wilson, K.L., et al. (2001) Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina. Trends in Biochemical Sciences, 26, 41-47. (Pubitemid 32124709)
7. Stuurman, N., Heins, S., &, Aebi, U., (1998) Nuclear lamins: their structure, assembly and interactions. Journal of Structural Biology, 122, 42-46.
8. Chen, P.L., Riley, D.J., &, Lee, W.H., (1996) Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes and Development, 10, 2794-2804. (Pubitemid 26384498)
9. Cao, H., &, Hegele, R.A., (2000) Nuclear Lamin A/C R482Q mutation in Canadian kindred's with Dunningan type familial partial lipodystophy. Human Molecular Genetics, 9, 109-112. (Pubitemid 30145295)
10. Garg, A., &, Misra, A., (2002) Hepatic steatosis, insulin resistance, and adipose tissue disorders. Journal of Clinical Endocrinology and Metabolism, 87, 3019-3022. (Pubitemid 34816337)
11. Novelli, G., Muchir, A., Sangiuolo, F., et al. (2002) Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding laminA/C. American Journal of Human Genetics, 71, 426-431. (Pubitemid 34800259)
12. Hegele, R.A., Cao, H., Harris, S.B., et al. (2000) Genetic variation in LMNA modulates plasma leptin and indices of obesity in aboriginal Canadians. Physiological Genomics, 3, 39-44.
13. Hegele, R.A., Huff, M.W., &, Young, T.K., (2001) Common genomic variation in LMNA modulate indexes of obesity in Inuit. The Journal of Clinical Endocrinology & Metabolism, 86, 2747-2751. (Pubitemid 32545733)
14. Steinle, N.I., Kazlauskaite, R., Imumorin, I.G., et al. (2004) Variation in the lamin A/C gene: association with metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 1708-1713. (Pubitemid 39180899)
15. Murase, Y., Yagi, K., Katsuda, Y., et al. (2002) An LMNA variant is associated with dyslipidimia and insulin resistance in the Japanese. Metabolism, 51, 1017-1021.
16. Wegner, L., &, Anderson, G., (2007) Common variation in LMNA increases susceptibility to type2 Diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population. Diabetes, 56, 694-698. (Pubitemid 46348468)
17. Bhardwaj, S., Misra, A., Khurana, L., et al. (2008) Childhood obesity in Asian Indians: a burgeoning cause of insulin resistance, diabetes and sub-clinical inflammation. Asia Pacific Journal of Clinical Nutrition, 17 (Suppl. 1), 172-175.
18. Misra, A., &, Khurana, L., (2008) Obesity and the metabolic syndrome in developing countries. Journal of Clinical Endocrinology and Metabolism, 93, S9-S30.
19. Dudeja, V., Misra, A., Pandey, R.M., et al. (2001) BMI does not accurately predict overweight in Asian Indians in northern India. British Journal of Nutrition, 86, 105-112. (Pubitemid 32640256)
20. Misra, A., Wasir, J.S., Vikram, N.K., et al. (2010) Cutoffs of abdominal adipose tissue compartments as measured by magnetic resonance imaging for detection of cardiovascular risk factors in apparently healthy adult Asian Indians in North India. Metabolic Syndrome and Related Disorders, 8, 243-247.
21. Misra, A., Vikram, N.K., Arya, S., et al. (2004) High prevalence of insulin resistance in post-pubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fat. International Journal of Obesity and Related Metabolic Disorders, 28, 1217-1226. (Pubitemid 39389577)
22. Vikram, N.K., Dwivedi, M., Sharma, R., et al. (2003) Correlation of C-reactive proteins with anthropometric profile percentage of body fat and lipids in healthy adolescents and young adults in urban north India. Atherosclerosis, 168, 305-313. (Pubitemid 36703330)
23. Friedewald, W.T., Levy, R.I., &, Fredrikson, D.S., (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clinical Chemistry, 18, 499-502.
24. Lahiri, D.K., &, Nurnberger Jr, J.I., (1991) A rapid non enzymatic method for the preparation of HMW enzymatic method from blood for RFLP studies. Nucleic acids Research, 19, 5444.
25. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA, 285, 2486-2497. Available at
26. Chobanian, A.V, Bakris, G.L, Black, H.R., et al. (2003) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. JAMA, 289, 2560-2571.
27. Vikram, N.K., Misra, A., Pandey, R.M., et al. (2008) Distribution of cut off points of fasting insulin in Asian Indian adolescent and association with metabolic syndrome. The Journal of the Association of Physicians of India, 56, 949-954.
28. Goel, K., Misra, A., Vikram, N.K., et al. (2010) Subcutaneous abdominal adipose tissue is associated with the metabolic syndrome in Asian Indians independent of intra-abdominal and total body fat. Heart, 96, 579-583.
29. Wardle, J., Carnell, S., Haworth, C.M., et al. (2006) Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. American Journal of Clinical Nutrition, 87, 398-404. (Pubitemid 351226077)
30. Selby, J.V., Newman, B., Quesenberry Jr, C.P., et al. (1989) Evidence of genetic influence on central body fat in middle aged twins. Human Biology, 61, 179-194.
31. Malis, C., Rasmussen, E.L., Poulsen, P., et al. (2005) Total and regional fat distribution is strongly influenced by genetics factors in young an elderly twins. Obesity Research, 13, 2139-2145.
32. Blakemore, A.I., &, Froguel, P., (2008) Is obesity our genetic legacy? Journal of Clinical Endocrinology and Metabolism, 93, S51-S56.
33. Chambers, J., Elliot, P., Zabaneh, D., et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nature Genetics, 6, 716-718. (Pubitemid 351748872)
34. Scuteri, A., Sanna, S., Chen, W.M., et al. (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genetics, 3, e115.