Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: The 14-3-3σ case

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 22, 2011, Pages 6867-6871

  Corradi, Valentina ^a   Mancini, Manuela ^b   Santucci, Maria Alessandra ^b   Carlomagno, Teresa ^c   Sanfelice, Domenico ^c   Mori, Mattia ^a   Vignaroli, Giulia ^a   Falchi, Federico ^a   Manetti, Fabrizio ^a   Radi, Marco ^a   Botta, Maurizio ^a,d  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d TEMPLE UNIVERSITY   (United States)

Author keywords

14 3 3; Leukemia; Molecular modeling; Protein protein interaction; T315I

Indexed keywords

4 (4 HEXYLOXYCARBONYL PHENYLAMINO) 3,5 DINITROBENZOIC ACID; 4 NITRO 2 [(4 PHENYL 6 4 TOLYL PYRIMIDIN 2 YL)HYDRAZONOMETHYL]PHENOL; ABELSON KINASE; BREAKPOINT CLUSTER REGION PROTEIN; BV 01; BV 02; BV 101; ISOLEUCINE; PROTEIN INHIBITOR; SERINE; STRATIFIN; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPUTER ANALYSIS; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG STRUCTURE; HIGH THROUGHPUT DOCKING; LD 50; MITOCHONDRIAL MEMBRANE; MOLECULAR DOCKING; MOLECULAR LIBRARY; MOUSE; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; WILD TYPE;

14-3-3 PROTEINS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE; DRUG DESIGN; EXONUCLEASES; HUMANS; MICE; MODELS, MOLECULAR; NEOPLASMS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTO-ONCOGENE PROTEINS C-ABL; SMALL MOLECULE LIBRARIES; TUMOR MARKERS, BIOLOGICAL;

MURINAE;

EID: 80054723464     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.011     Document Type: Article

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