Muscarinic receptor subtypes involved in regulation of colonic motility in mice: Functional studies using muscarinic receptor-deficient mice

European Journal of Pharmacology

Volumn 670, Issue 1, 2011, Pages 236-243

  Kondo, Takaji ^a   Nakajima, Miwa ^a   Teraoka, Hiroki ^a   Unno, Toshihiro ^b   Komori, Sei Ichi ^b   Yamada, Masahisa ^c   Kitazawa, Takio ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY   (Japan)

Author keywords

Keywords; Knockout mouse; Mouse colon; Muscarinic receptor; Nitrergic nerve

Indexed keywords

MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; CHOLINERGIC ACTIVITY; COLON MOTILITY; CONTROLLED STUDY; DEFECATION; DESCENDING COLON; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CONTRACTION; MALE; MOUSE; NITRERGIC NERVE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SMOOTH MUSCLE RELAXATION; WILD TYPE;

(4-(M-CHLOROPHENYLCARBAMOYLOXY)-2-BUTYNYL)TRIMETHYLAMMONIUM CHLORIDE; ANIMALS; BIOMECHANICS; CARBACHOL; COLON; DEFECATION; FEMALE; GASTROINTESTINAL MOTILITY; GENE KNOCKOUT TECHNIQUES; MALE; MICE; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; PIRENZEPINE; RECEPTORS, MUSCARINIC;

EID: 80054716482     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.08.034     Document Type: Article

References (40)

1. L. Borjesson, A. Ali, S. Nordgren, and D.S. Delbro Relaxation of rat distal colon by activation of muscarinic neural receptors: possible involvement of P2y purinoceptors J. Auton. Nerv. Syst. 81 2000 53 58 (Pubitemid 30409977)
2. S.M. Brierley, K. Nichols, D.J. Grasby, and S.A. Waterman Neural mechanisms underlying migrating motor complex formation in mouse isolated colon Br. J. Pharmacol. 132 2001 507 517 (Pubitemid 32142365)
3. M.P. Caulfield, and N.J. Birdsall International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors Pharmacol. Rev. 50 1998 279 290 (Pubitemid 28304029)
4. 2 muscarinic receptors in trachea and ileum of diabetic rats Br. J. Pharmacol. 135 2002 1355 1362 (Pubitemid 34270906)
5. 7 receptor subtypes in the initiation, generation, and propagation of the murine colonic migrating motor complex Am. J. Physiol. Gastrointest. Liver Physiol. 299 2010 G144 G157
6. 3 muscarinic receptors in the circular muscle of the guinea-pig ileum Nauyn-Schmiedeberg's Arch. Pharmacol. 351 1995 237 243
7. R.M. Eglen Muscarinic receptors and gastrointestinal smooth muscle function Life Sci. 23 2001 2573 2578 (Pubitemid 32455696)
8. R.M. Eglen, S.S. Hegde, and N. Watson Muscarinic receptor subtypes and smooth muscle function Pharmacol. Rev. 48 1996 531 565 (Pubitemid 27023820)
9. F.J. Ehlert, R.S. Ostrom, and G.W. Sawyer Subtypes of the muscarinic receptor in smooth muscle Life Sci. 61 1997 1729 1740 (Pubitemid 27440628)
10. 3 muscarinic receptors in guinea-pig ileum and transfected cells J. Pharmacol. Exp. Ther. 289 1999 981 992 (Pubitemid 29191257)
11. R. Fida, D.J. Lyster, R.A. Bywater, and G.S. Taylor Colonic migrating motor complexes (CMMCs) in the isolated mouse colon Neurogastroenterol. Motil. 9 1997 99 107 (Pubitemid 27260806)
12. 4 muscarinic receptor subtypes J. Pharmacol. Exp. Ther. 328 2009 331 342
13. 2 muscarinic acetylcholine receptor knockout mice Proc. Natl. Acad. Sci. U. S. A. 96 1999 1692 1697 (Pubitemid 29098513)
14. G. Gourcerol, L. Wang, D.W. Adelson, M. Larauche, Y. Taché, and M. Million Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G992 G1002
15. A.M. Harrington, J.M. Hutson, and B.R. Southwell Immunohistochemical localization of cholinergic muscarinic receptor subtype 1 (M1r) in the guinea-pig and human enteric nervous system J. Chem. Neuroanat. 33 2007 193 201 (Pubitemid 46755540)
16. 3R in the human colon Neurogastroenterol. Motil. 22 2010 999 1008
17. 2+ influx pathways in taenia coli Br. J. Pharmacol. 122 1997 985 992 (Pubitemid 27494208)
18. 1 receptor activation Eur. J. Pharmacol. 331 1997 213 219 (Pubitemid 27331452)
19. A.A. Izzo, N. Mascolo, F. Borrelli, and F. Capasso Defecation, intestinal fluid accumulation and motility in rodents: implications of cannabinoid CB1 receptors Naunyn-Schimiedeberg's Arch. Pharmacol. 359 1999 65 70 (Pubitemid 29142572)
20. 3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice Eur. J. Pharmacol. 554 2007 212 222 (Pubitemid 44879413)
21. N.I. Kortezova, L.I. Shikova, E.A. Milusheva, D.E. Itzev, V.A. Bagaev, and Z.N. Mizhorkova Muscarinic modulation of nitrergic neurotransmission in guinea-pig gastric fundus Neurogastroenterol. Motil. 16 2004 155 165 (Pubitemid 38580960)
22. N.-M. Law, A.E. Bharucha, A.S. Undale, and A.R. Zinsmeister Cholinergic stimulation enhances colonic motor activity, transit, and sensation in humans Am. J. Physiol. Gastrointest. Liver Physiol. 281 2001 G1228 G1237
23. A.I. Levey Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain Life Sci. 52 1993 441 448
24. D.J. Lyster, R.A. Bywater, and G.S. Taylor Neurogenic control of myoelectric complexes in the mouse isolated colon Gastroenterology 108 1995 1371 1378
25. J.G. McCarron, J.W. Craig, K.N. Bradley, and T.C. Muir Agonist-induced phasic and tonic responses in smooth muscle are mediated by InsP3 J. Cell Sci. 115 2002 2207 2218 (Pubitemid 34746386)
26. 1 receptors stimulate a nonadrenergic noncholinergic inhibitory pathway in the isolated rat duodenum J. Pharmacol. Exp. Ther. 244 1987 680 684 (Pubitemid 18076614)
27. 1 muscarinic receptor activation in the rat small intestine Br. J. Pharmacol. 127 1999 309 313 (Pubitemid 29213263)
28. L. Pinto, A.A. Izzo, M. Cascio, T. Bisogno, K. Hospodar-Scott, D.R. Brown, N. Mascolo, V. Di Marzo, and F. Capasso Endocannabinoids as physiological regulators of colonic propulsion in mice Gastroenterology 123 2002 227 234 (Pubitemid 34747543)
29. A.K. Powell, and R.A. Bywater Endogenous nitric oxide release modulates the direction and frequency of colonic migrating motor complexes in the isolated mouse colon Neurogastroenterol. Motil. 13 2001 221 228 (Pubitemid 32525673)
30. M.H. Richards, and P.L. Van Giersbergen Differences in agonist potency ratios at human m1 muscarinic receptors expressed in A9L and CHO cells Life Sci. 57 1995 397 402
31. T. Sakamoto, T. Unno, T. Kitazawa, T. Taneike, M. Yamada, J. Wess, M. Nishimura, and S. Komori Three distinct muscarinic signaling pathways for cationic channel activation in mouse gut smooth muscle cells J. Physiol. 582 2007 41 61 (Pubitemid 46993560)
32. 3 muscarinic receptors in the guinea pig colon J. Pharmacol. Exp. Ther. 284 1998 269 277 (Pubitemid 28109555)
33. R. Serio, M. Alessandro, M.G. Zizzo, M. Tamburello, and F. Mule Neurotransmitters involved in the fast inhibitory junctional potentials in mouse distal colon Eur. J. Pharmacol. 460 2003 183 190 (Pubitemid 36139987)
34. 3-receptor knockout mice J. Pharmacol. Exp. Ther. 304 2003 675 682 (Pubitemid 36152344)
35. N. Struckmann, S. Schwering, S. Wiegand, A. Gschnell, M. Yamada, W. Kummer, J. Wess, and R.V. Haberberger Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice Mol. Pharmacol. 64 2003 1444 1451 (Pubitemid 37532234)
36. 3 muscarinic receptor mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice Br. J. Pharmacol. 146 2005 98 108 (Pubitemid 43086099)
37. E.S. Vizi, O. Kobayashi, and A. Torocsik Heterogeneity of presynaptic muscarinic receptors involved in modulation of transmitter release Neuroscience 31 1989 259 267 (Pubitemid 19209716)
38. J. Wess Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications Annu. Rev. Pharmacol. Toxicol. 44 2004 423 450 (Pubitemid 38263848)
39. C.U. Wiklund, N.P. Wiklund, and L.E. Gustafsson Modulation of neuroeffector transmission by endogenous nitric oxide: a role for acetylcholine receptor-activated nitric oxide formation, as indicated by measurements of nitric oxide/nitrite release Eur. J. Pharmacol. 3 1993 235 242 (Pubitemid 23255222)
40. 3 muscarinic acetylcholine receptor are hypophagic and lean Nature 410 2001 207 212 (Pubitemid 32216592)