Receptor-mediated activation of a proinsulin-transferrin fusion protein in hepatoma cells

Journal of Controlled Release

Volumn 155, Issue 3, 2011, Pages 386-392

  Wang, Yan ^a   Chen, Yu Sheng ^a   Zaro, Jennica L ^a   Shen, Wei Chiang ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Bifunctional fusion protein; Insulin; Prohormone conversion; Proinsulin; Receptor mediated endocytosis and recycling; Transferrin

Indexed keywords

FUSION PROTEINS; PROHORMONE CONVERSION; PROINSULIN; RECEPTOR-MEDIATED ENDOCYTOSIS; TRANSFERRIN;

CELLS; GLUCOSE; INSULIN; MOLECULAR BIOLOGY; PHOSPHORYLATION; PROTEINS; RECYCLING; TUMORS;

CELL CULTURE;

HORMONE PRECURSOR; HYBRID PROTEIN; INSULIN; PROINSULIN; PROTEIN KINASE B; PROTEINASE; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOCYTOSIS; GLUCONEOGENESIS; GLUCOSE TRANSPORT; HEPATOMA CELL; INCUBATION TIME; INSULIN RELEASE; MICROTUBULE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOIMMUNOASSAY; RAT; TEMPERATURE DEPENDENCE; TRANS GOLGI NETWORK;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CULTURE MEDIA, SERUM-FREE; ENDOCYTOSIS; GLUCOSE; HEK293 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MICE; PRODRUGS; PROINSULIN; RADIOIMMUNOASSAY; RATS; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TRANSFERRIN;

EID: 80054715740     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.06.029     Document Type: Article

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