A recombinant prodrug type approach for triggered delivery of streptokinase

Journal of Controlled Release

Volumn 59, Issue 1, 1999, Pages 119-122

  Wang, Hong ^a   Song, Hui ^a   Yang, Victor C ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Hirudin; Hirulog streptokinase (HSK) fusion protein; Prodrug type delivery system; Recombinant DNA technology; Thrombin; Triggered release

Indexed keywords

HIRULOG; HIRULOG STREPTOKINASE FUSION PROTEIN; HYBRID PROTEIN; PLASMIN; PLASMINOGEN; PRODRUG; STREPTOKINASE; THROMBIN; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ARTICLE; BLOOD CLOT LYSIS; DRUG ACTIVITY; DRUG RELEASE; HUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RECOMBINANT DNA TECHNOLOGY; THROMBOSIS;

AMINO ACID SEQUENCE; ANTITHROMBINS; BINDING SITES; FIBRINOLYTIC AGENTS; HIRUDINS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PLASMINOGEN; PRODRUGS; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; STREPTOKINASE;

EID: 0032945676     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00019-X     Document Type: Article

References (6)

1. Lijnen H.R., Collen D. Strategies for the improvement of thrombolytic agents. Thromb. Haemost. 66:1991;88-110.
2. United States Department of Health and Human Services, DHHS Publication No. (PHS) 85-1232, National Center for Health Statistics, Hyattsville, MD, 1984.
3. Maraganore J.M., Bourdon P., Jablonski J., Ramachandran K.L., Fenton J.W. Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin. Biochemistry. 29:1990;7095-7101.
4. Markwardt F. Current status of antithrombin agents as novel antithrombotics. Proceedings of the Fourth International Symposium on Advances in Anticoagulant, Antithrombotic and Thrombolytic Drugs. 1993;IBC Conferences, Southborough, MA.
5. Lottenberg R., Broder C., Boyle M.D.P., et al. Cloning, sequence analysis, and expression in Escherichia coli of a streptococcal plasmin receptor. J. Bacteriol. 174:1992;5024-5210.
6. Bode C., Runge M.S., Branscomb E.E., Newell J.B., Matsueda G.R., Haber E. Antibody-directed fibrinolysis. J. Biol. Chem. 264:1989;944-948.