Determination of metformin in human plasma and urine by high-performance liquid chromatography using small sample volume and conventional octadecyl silane column

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 13, Issue 4, 2010, Pages 486-494

  Gabr, Raniah Q ^a   Padwal, Raj S ^a   Brocks, Dion R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 BUTANOL HEXANE; ACETIC ACID; ACETONITRILE; DODECYL SULFATE SODIUM; HEXANE; METFORMIN; OCTADECYLSILANE; RANITIDINE; SILANE DERIVATIVE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG MONITORING; DRUG URINE LEVEL; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PLASMA CONCENTRATION-TIME CURVE; QUANTITATIVE ANALYSIS; SAMPLE SIZE; SENSITIVITY AND SPECIFICITY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDITY;

EID: 78650381848     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j32c71     Document Type: Article

References (27)

1. Canadian Diabetes Association 2008 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Can J Diab 2008; 32: S1-S201.
2. Aburuz S, Millership J, Mcelnay J. Determination of metformin in plasma using a new ion pair solid phase extraction technique and ion pair liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 2003; 798: 203-209.
3. Amini H, Ahmadiani A, Gazerani P.Determination of metformin in human plasma by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 2005; 824: 319-322.
4. Brohon J, Noel M. Determination of metformin in plasma therapeutic levels by gas--liquid chromatography using a nitrogen detector. J Chromatogr 1978; 146: 148-151.
5. Charles BG, Jacobsen NW, Ravenscroft PJ.Rapid liquid-chromatographic etermination of metformin in plasma and urine. Clin Chem 1981; 27: 434-436.
6. Chen X, Gu Q, Qiu F, Zhong D. Rapid determination of metformin in human plasma by liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci 2004; 802: 377-381.
7. Cheng CL, Chou CH. Determination of metformin in human plasma by highperformance liquid chromatography with spectrophotometric detection. J Chromatogr B Biomed Sci Appl 2001; 762: 51-58.
8. Garrett ER, Tsau J, Hinderling PH. Application of ion-pair methods to drug extraction from biological fluids. II. Quantitative determination of biguanides in biological fluids and comparison of protein binding estimates. J Pharm Sci 1972; 61: 1411-1418.
9. Heinig K, Bucheli F. Fast liquid chromatographic-tandem mass spectrometric (LC-MS-MS) determination of metformin in plasma samples. J Pharm Biomed Anal 2004; 34: 1005-1011.
10. Henry CW, 3rd, Shamsi SA, Warner IM. Separation of natural pyrethrum extracts using micellar electrokinetic chromatography. J Chromatogr A 1999; 863: 89-103.
11. Huupponen R, Ojala-Karlsson P, Rouru J, Koulu M. Determination of metformin in plasma by high-performance liquid chromatography. J Chromatogr 1992; 583: 270-273.
12. Kah Hay Y, Kok Khiang P. Simple highperformance liquid chromatographic method for the determination of metformin in human plasma. J Chromatogr B Biomed Sci Appl 1998; 710: 243-246.
13. Keal J, Somogyi A. Rapid and sensitive highperformance liquid chromatographic assay for metformin in plasma and urine using ion-pair extraction techniques. J Chromatogr 1986; 378: 503-508.
14. Kolte BL, Raut BB, Deo AA, Bagool MA, Shinde DB. Simultaneous determination of metformin in combination with rosiglitazone by reversed-phase liquid chromatography. J Chromatogr Sci 2004; 42: 70-73.
15. Matin SB, Karam JH, Forshan PH. Simple elcetron capture gas chromatographic method for the determination of oral hypoglycemic biguanidis in biological fluids. Anal Chem 1975; 47: 545-548.
16. Pentikainen PJ, Neuvonen PJ, Penttila A. Pharmacokinetics of metformin after intravenous and oral administration to man. Eur J Clin Pharmacol 1979; 16: 195-202.
17. Porta V, Schramm SG, Kano EK, Koono EE, Armando YP, Fukuda K, Serra CH. HPLC-UV determination of metformin in human plasma for application in pharmacokinetics and bioequivalence studies. J Pharm Biomed Anal 2008; 46: 143-147.
18. Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG. Kidney function and age are both predictors of pharmacokinetics of metformin. J Clin Pharmacol 1995; 35: 1094-1102.
19. Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 1996; 30: 359-371.
20. Somogyi A, Stockley C, Keal J, Rolan P, Bochner F. Reduction of metformin renal tubular secretion by cimetidine in man. Br J Clin Pharmacol 1987; 23: 545-551.
21. Song JZ, Chen HF, Tian SJ, Sun ZP. Determination of metformin in plasma by capillary electrophoresis using field-amplified sample stacking technique. J Chromatogr B Biomed Sci Appl 1998; 708: 277-283.
22. Tache F, David V, Farca A, Medvedovici A. HPLC-DAD determination of Metformin in human plasma using derivatization with pnitrobenzoyl chloride in a biphasic system. Microchemical Journal 2001; 68: 13-19.
23. Tahara K, Yonemoto A, Yoshiyama Y, Nakamura T, Aizawa M, Fujita Y, Nishikawa T. Determination of antihyperglycemic biguanides in serum and urine using an ion-pair solid-phase extraction technique followed by HPLC-UV on a pentafluorophenylpropyl column and on an octadecyl column. Biomed Chromatogr 2006; 20: 1200-1205.
24. Vesterqvist O, Nabbie F, Swanson B. Determination of metformin in plasma by highperformance liquid chromatography after ultrafiltration. J Chromatogr B Biomed Sci Appl 1998; 716: 299-304.
25. Wang Y, Tang Y, Gu J, Fawcett JP, Bai X. Rapid and sensitive liquid chromatographytandem mass spectrometric method for the quantitation of metformin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2004; 808: 215-219.
26. Zarghi A, Foroutan SM, Shafaati A, Khoddam A. Rapid determination of metformin in human plasma using ion-pair HPLC. J Pharm Biomed Anal 2003; 31: 197-200.
27. Zhang M, Moore GA, Lever M, Gardiner SJ, Kirkpatrick CM, Begg EJ. Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 766: 175-179.