Vascular endothelial growth factor (VEGF 165) plus basic fibroblast growth factor (bFGF) producing cells induce a mature and stable vascular network - A future therapy for ischemically challenged tissue

Journal of Surgical Research

Volumn 171, Issue 1, 2011, Pages 329-338

  Spanholtz, Timo A ^a   Theodorou, Panagiotis ^a   Holzbach, Thomas ^b   Wutzler, Sebastian ^c   Giunta, Riccardo E ^b   MacHens, Hans Guenther ^b  

^a University Hospital of Witten/Herdecke   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

arteriogenesis; bFGF; cell based gene transfer; VEGF

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; VASCULOTROPIN 165;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CARDIOVASCULAR SYSTEM; CELL MATURATION; CELL TRANSPLANTATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; GENETIC CODE; IMMUNOHISTOLOGY; IMPLANTATION; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIA; MICROANGIOGRAPHY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKIN FLAP; SKIN NECROSIS; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; FEMALE; FIBROBLAST GROWTH FACTOR 2; FIBROBLASTS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GRAFT SURVIVAL; ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SURGICAL FLAPS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80054703676     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.03.033     Document Type: Article

References (31)

1. G.L. Semenza Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling J Cell Biochem 102 2007 840
2. N. Ferrara, H.P. Gerber, and J. LeCouter The biology of VEGF and its receptors Nat Med 9 2003 669
3. R.E. Giunta, T. Holzbach, and C. Taskov AdVEGF165 gene transfer increases survival in overdimensioned skin flaps J Gene Med 7 2005 297
4. J.A. Nagy, D. Feng, and E. Vasile Permeability properties of tumor surrogate blood vessels induced by VEGF-A Lab Invest 86 2006 767
5. P. Carmeliet VEGF as a key mediator of angiogenesis in cancer Oncology 69 Suppl. 3 2005 4
6. T. Holzbach, I. Neshkova, and D. Vlaskou Searching for the right timing of surgical delay: Angiogenesis, vascular endothelial growth factor and perfusion changes in a skin-flap model J Plast Reconstr Aesthet Surg 62 2009 1534
7. M. Simons Angiogenesis: Where do we stand now? Circulation 111 2005 1556
8. T. Spanholtz, A. Maichle, and C. Niedworok Timing and targeting of cell-based VEGF(165) gene expression in ischemic tissue J Surg Res 151 2009 153
9. J.A. Rhodin, and H. Fujita Capillary growth in the mesentery of normal young rats. Intravital video and electron microscope analyses J Submicrosc Cytol Pathol 21 1989 1
10. R.D. Kenagy, C.E. Hart, and W.G. Stetler-Stevenson Primate smooth muscle cell migration from aortic explants is mediated by endogenous platelet-derived growth factor and basic fibroblast growth factor acting through matrix metalloproteinases 2 and 9 Circulation 96 1997 3555
11. S. Rajagopalan, M. Shah, and A. Luciano Adenovirus-mediated gene transfer of VEGF(121) improves lower-extremity endothelial function and flow reserve Circulation 104 2001 753
12. F. Yi, W.Y. Guo, and A.L. Lu Vascular endothelial growth factor expressing mesenchymal stem cells improves cardiac function in chronic myocardial infarction in pigs Chin Med J (Engl) 119 2006 1664
13. S. Taverna, G. Ghersi, and A. Ginestra L. Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells J Biol Chem 278 2003 51911
14. X.T. Sun, Y.T. Ding, and X.G. Yan Angiogenic synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in an in vitro quantitative microcarrier-based three-dimensional fibrin angiogenesis system World J Gastroenterol 10 2004 2524
15. G.C. Hughes, S.S. Biswas, and B. Yin Therapeutic angiogenesis in chronically ischemic porcine myocardium: Comparative effects of bFGF and VEGF Ann Thorac Surg 77 2004 812
16. H.G. Machens, J. Salehi, and H. Weich Angiogenic effects of injected VEGF165 and sVEGFR-1 (sFLT-1) in a rat flap model J Surg Res 111 2003 136
17. R.M. McFarlane, G. Deyoung, and R.A. Henry The Design of a Pedicle Flap in the Rat to Study Necrosis and Its Prevention Plast Reconstr Surg 35 1965 177
18. H.G. Machens, S. Grzybowski, and B. Bucsky A technique to detect and to quantify fasciocutaneous blood vessels in small laboratory animals ex vivo J Surg Res 131 2006 91
19. S. Zacchigna, E. Tasciotti, and C. Kusmic In vivo imaging shows abnormal function of vascular endothelial growth factor-induced vasculature Hum Gene Ther 18 2007 515
20. S. Banai, M.T. Jaklitsch, and M. Shou Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs Circulation 89 1994 2183
21. D.T. Connolly, D.M. Heuvelman, and R. Nelson Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis J Clin Invest 84 1989 1470
22. N. Ferrara, K. Houck, and L. Jakeman Molecular and biological properties of the vascular endothelial growth factor family of proteins Endocr Rev 13 1992 18
23. R. Tsuboi, and D.B. Rifkin Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice J Exp Med 172 1990 245
24. Y. Sato, and D.B. Rifkin Autocrine activities of basic fibroblast growth factor: Regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis J Cell Biol 107 1988 1199
25. G.T. Stavri, I.C. Zachary, and P.A. Baskerville Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. Synergistic interaction with hypoxia Circulation 92 1995 11
26. J. Mattern, R. Koomagi, and M. Volm Coexpression of VEGF and bFGF in human epidermoid lung carcinoma is associated with increased vessel density Anticancer Res 17 1997 2249
27. J.C. Tille, J. Wood, and S.J. Mandriota Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro J Pharmacol Exp Ther 299 2001 1073
28. E. Cornali, C. Zietz, and R. Benelli Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma Am J Pathol 149 1996 1851
29. T. Asahara, C. Bauters, and L.P. Zheng Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo Circulation 92 1995 II365
30. K. White, S.A. Nicklin, and A.H. Baker Novel vectors for in vivo gene delivery to vascular tissue Expert Opin Biol Ther 7 2007 809
31. J.M. Davidson First-class delivery: Getting growth factors to their destination J Invest Dermatol 128 2008 1360