Decolonization to Prevent Infections with Staphylococcus aureus in Patients Undergoing Hemodialysis: A Review of Current Evidence

Seminars in Dialysis

Volumn 24, Issue 5, 2011, Pages 533-539

  Kallen, Alexander J ^a   Jernigan, John A ^a   Patel, Priti R ^a  

^a NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; TOPICAL ANTIINFECTIVE AGENT;

ANTISEPSIS; HETEROZYGOTE; HUMAN; RENAL REPLACEMENT THERAPY; REVIEW; STAPHYLOCOCCUS INFECTION;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS, LOCAL; ANTISEPSIS; CARRIER STATE; HUMANS; RENAL DIALYSIS; STAPHYLOCOCCAL INFECTIONS;

EID: 80054696185     PISSN: 08940959     EISSN: 1525139X     Source Type: Journal    
DOI: 10.1111/j.1525-139X.2011.00959.x     Document Type: Review

References (51)

1. Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, Fridkin SK; for the National Healthcare Safety Network team and participating National Healthcare Safety Network facilities: Antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 29:996-1011, 2008
2. Klevens RM, Edwards JR, Andrus ML, Peterson KD, Dudek MA, Horan TC; the NHSN participants in outpatient dialysis surveillance: Dialysis surveillance report: National Healthcare Safety Network (NHSN)-data summary 2006. Semin Dial 21:24-28, 2008
3. Engemann JJ, Friedman JY, Reed SD, Griffiths RI, Szezech LA, Kaye KS, Stryjewski ME, Reller LB, Schulman KA, Corey GR, Fowler VG: Clinical outcomes and costs due to Staphylococcus aureus bacteremia among patients receiving long-term hemodialysis. Infect Control Hosp Epidemiol 26:534-539, 2005
4. Nissenson AR, Dylan ML, Griffiths RI, Yu HT, Dean BB, Danese MD, Dubois RW: Clinical and economic outcomes of Staphylococcus aureus septicemia in ESRD patients receiving hemodialysis. Am J Kidney Dis 46:301-308, 2005
5. CDC: Invasive methicillin-resistant Staphylococcus aureus infections among dialysis patients-United States, 2005. MMWR Morb Mortal Wkly Rep 56:197-199, 2007
6. Kallen AJ, Mu Y, Bulens S, Reingold A, Petit S, Gershman K, Ray SM, Harrison LH, Lynfield R, Dumyati G, Townes JM, Schaffner W, Patel PR, Fridkin SK: Health care-associated invasive MRSA infections, 2005-2008. JAMA 304:641-648, 2010
7. Kuehnert MJ, Kruszon-Moran D, Hill HA, McQuillan G, McAllister SK, Fosheim G, McDougal LK, Chaitram J, Jensen B, Fridkin SK, Killgore G, Tenover FC: Prevalence of Staphylococcus aureus nasal colonization in the United States, 2001-2002. J Infect Dis 193:172-179, 2006
8. Gorwitz RA, Kruzon-Moran D, McAllister SK, McQuillan G, McDougal LK, Fosheim GE, Jensen BJ, Killgore G, Tenover FC, Kuehnert MJ: Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004. J Infect Dis 197:1226-1234, 2008
9. Boelart JR, De Smedt RA, De Baere YA, Godard CA, Matthys EG, Schurgers ML, Daneels RF, Gordts BZ, Van Landuyt HW: The influence of calcium mupirocin nasal ointment on the incidence of Staphylococcus aureus infections in hemodialysis patients. Nephrol Dial Transplant 4:278-281, 1989
10. Holton DL, Nicolle LE, Diley D, Bernstein K: Efficacy of mupirocin nasal ointment in eradicating Staphylococcus aureus nasal carriage in chronic hemodialysis patients. J Hosp Infect 17:133-137, 1991
11. Boelaert JR, Van Landuyt HW, Godard CA, Daneels RF, Schurgers ML, Matthys EG, De Baere YA, Gheyle DW, Gordts BZ, Herwaldt LA: Nasal mupirocin ointment decreases the incidence of Staphylococcus aureus bacteremias in hemodialysis patients. Nephrol Dial Transplant 8:235-239, 1993
12. Kluytmans JAJW, Manders MJ, van Bommel E, Verbrugh H: Elimination of nasal carriage of Staphylococcus aureus in hemodialysis patients. Infect Control Hosp Epidemiol 17:793-797, 1996
13. Kirmani N, Tuazon CU, Murray HW, Parrish AE, Shagren JN: Staphylococcus aureus carriage rate of patients receiving long-term hemodialysis. Arch Intern Med 138:1657-1659, 1978
14. Mermel LA, Eells SJ, Acharya MK, Cartony JM, Dacus D, Fadem S, Gay EA, Gordon S, Lonks JR, Perl TM, McDougal LK, McGowan JE, Maxey G, Morse D, Tenover FC: Quantitative analysis and molecular fingerprinting of methicillin-resistant Staphylococcus aureus nasal colonization in different patient populations: a prospective, multicenter study. Infect Control Hosp Epidemiol 31:592-597, 2010
15. Johnson LB, Jose J, Yousif F, Pawlak J, Saravolatz LD: Prevalence of colonization with community-associated methicillin-resistant Staphylococcus aureus among end-stage renal disease patients and healthcare workers. Infect Control Hosp Epidemiol 30:4-8, 2009
16. Eriksen NH, Espersen F, Rosdahl VT, Jensen K: Carriage of Staphylococcus aureus among 104 healthy persons during a 19-month period. Epidemiol Infect 115:51-60, 1995
17. Yu VL, Goetz A, Wagener M, Smith PB, Rihs JD, Hanchett J, Zuravleff JJ: Staphylococcus aureus nasal carriage and infection in patients on hemodialysis. N Engl J Med 315:91-96, 1986
18. Nouwen J, Schouton J, Schneebergen P, Snijders S, Maaskant J, Koolen M, van Belkum A, Verbrugh HA: Staphylococcus aureus carriage patterns and the risk of infections associated with continuous peritoneal dialysis. J Clin Microbiol 44:2233-2236, 2006
19. Pujol M, Pena C, Pallares R, Ariza J, Ayats J, Dominguez MA, Gudiol F: Nosocomial Staphylococcus aureus bacteremia among nasal carriers of methicillin-resistant and methicillin-susceptible strains. Am J Med 100:509-516, 1996
20. Von Eiff C, Becker K, Machka K, Stammer H, Peters G: Nasal carriage as a source of Staphylococcus aureus bacteremia. N Engl J Med 344:11-16, 2001
21. Squier C, Rihs JD, Risa KJ, Sagnimeni A, Wagener MM, Stout J, Muder RR, Singh N: Staphylococcus aureus rectal carriage an its association with infections in patients in a surgical intensive care unit and a liver transplant unit. Infect Control Hosp Epidemiol 23:495-501, 2002
22. Nilsson P, Ripa T: Staphylococcus aureus throat colonization is more frequent than colonization in the anterior nares. J Clin Microbiol 44:3334-3339, 2006
23. Mertz D, Frei R, Jaussi B, Tietz A, Stebler C, Fluckiger U, Widmer AF: Throat swabs are necessary to reliably detect carriers of Staphylococcus aureus. Clin Infect Dis 45:475-477, 2007
24. Wertheim HF, Verveer J, Boelens HA, van Belkum A, Verbrugh HA, Vos MC: Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults. Antimicrob Agents Chemother 49:1465-1467, 2005
25. Dancer SJ, Noble WC: Nasal, axillary, and perineal carriage of Staphylococcus aureus among women: identification of strains producing epidermolytic toxin. J Clin Pathol 44:681-684, 1991
26. Simor AE, Phillips E, McGeer A, Konvalinka A, Loeb M, Devlin R, Kiss A: Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for eradication of methicillin-resistant Staphylococcus aureus colonization. Clin Infect Dis 44:178-185, 2007
27. Wendt C, Schinke S, Wurtemberger M, Oberdorfer K, Bock-Hensley O, von Baum H: Value of whole-body washing with chlorhexidine for the eradication of methicillin-resistant Staphylococcus aureus: a randomized, placebo-controlled, double-blind clinical trial. Infect Control Hosp Epidemiol 28:1036-1043, 2007
28. Nguyen MH, Kauffman CA, Goodman RP, Squier C, Arbeit RD, Singh N, Wagener MM, Yu VL: Nasal carriage of and infection with Staphylococcus aureus in HIV-infected patients. Ann Intern Med 130:221-225, 1999
29. Robicsek A, Beaumont JL, Thomson RB, Govindarajan G, Peterson LR: Topical therapy for methicillin-resistant Staphylococcus aureus colonization: impact on infection risk. Infect Control Hosp Epidemiol 30:623-632, 2009
30. Harbarth S, Fankhauser C, Schrenzel J, Christenson J, Gervaz P, Bandiera-Clerc C, Renzi G, Vernaz N, Sax H, Pittet D: Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA 299:1149-1157, 2008
31. Patel JB, Gorwitz RJ, Jernigan JA: Mupirocin resistance. Clin Infect Dis 49:935-941, 2009
32. Jones JC, Rogers TJ, Brookmeyer P, Dunne Jr WM, Storch GA, Coopersmith CM, Frazer VJ, Warren DK: Mupirocin resistance in patients colonized with methicillin-resistant Staphylococcus aureus in a surgical intensive care unit. Clin Infect Dis 45:541-547, 2007
33. Kallen AJ, Wilson CT, Larson RJ: Perioperative intranasal mupirocin for the prevention of surgical-site infections: systematic review of the literature and meta-analysis. Infect Control Hosp Epidemiol 26:916-922, 2005
34. Fawley WN, Parnell P, Hall J, Wilcox MH: Surveillance for mupirocin resistance following introduction of routine peri-operative prophylaxis with nasal mupirocin. J Hosp Infect 62:327-332, 2006
35. Perl TM, Cullen JJ, Wenzel RP, Zimmerman B, Pfaller MA, Sheppard D, Twombley J, French PP, Herwaldt LA: Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. N Engl J Med 346:1871-1877, 2002
36. Harbarth S, Liassine N, Dharan S, Herrault P, Auckenthaler R, Pittet D: Risk factors for persistent carriage of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 31:1380-1385, 2000
37. Walker ES, Vasquez JE, Dula R, Bullock H, Sarubbi FA: Mupirocin-resistant, methicillin-resistant Staphylococcus aureus; does mupirocin remain effective. Infect Control Hosp Epidemiol 24:342-346, 2003
38. Falagas ME, Fragoulis KN, Bliziotis IA: Oral rifampin for prevention of S. aureus carriage-related infections in patients with renal failure-a meta-analysis of randomized controlled trials. Nephrol Dial Transplant 21:2536-2542, 2006
39. Levin A, Mason J, Indal KK, Fong W, Goldstein MB: Prevention of hemodialysis subclavian vein catheter infections by topical povidone iodine. Kidney Int 40:934-938, 1991
40. Sesso R, Barbosa D, Leme IL, Sader H, Canziani ME, Manfredi S, Draibe S, Pignatari AC: Staphylococcus aureus prophylaxis in hemodialysis patients using central venous catheter: effect of mupirocin ointment. J Am Soc Nephrol 9:1085-1092, 1998
41. Johnson DW, MacGinley R, Kay TD, Hawley CM, Campbell SB, Isbel Nm, Hollett P: A randomized trial of topical exit site mupirocin application in patients with tunneled, cuffed hemodialysis catheters. Nephrol Dial Transplant 17:1802-1807, 2002
42. Lok CE, Stanley KE, Hux JE, Richardson R, Tobe SW, Conly J: Hemodialysis infection prevention with polysporin ointment. J Am Soc Nephrol 13:169-179, 2003
43. Battistella A, Bhola C, Lok CE: Long-term follow-up of the hemodialysis infection prevention with polysporin ointment (HIPPO) study: a quality improvement report. Am J Kidney Dis 57:432-441, 2011
44. Flowers RH, Schwenzer KJ, Kopel RF, Fisch MJ, Tucker SI, Farr BM: Efficacy of an attachable subcutaneous cuff for the prevention on intravascular catheter-related infection: a randomized controlled trial. JAMA 261:878-883, 1989
45. Johnson DW, van Eps C, Mudge DW, Wiggins KJ, Armstrong K, Hawley CM, Campbell SB, Isbel NM, Nimmo GR, Gibbs H: Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. J Am Soc Nephrol 16:1456-1462, 2005
46. Taconelli E, Carmeli Y, Aizer A, Ferreira G, Foreman MG, D'Agata EMC: Mupirocin prophylaxis to prevent Staphylococcus aureus infection in patients undergoing dialysis: a meta-analysis. Clin Infect Dis 37:1629-1638, 2003
47. Labriola L, Crott R, Desmet C, Andre G, Jadoul M: Infectious complications following conversion to buttonhold cannulation of native arteriovenous fistulas: a quality improvement report. Am J Kidney Dis 57:442-448, 2011
48. Nesrallah GE, Cuerden M, Wong JHS, Pierratos A: Staphylococcus aureus bacteremia and buttonhole cannulation: long term safety and efficacy of mupirocin prophylaxis. Clin J Am Soc Nephrol 5:1047-1053, 2010
49. Marticorena RM, Hunter J, Macleod S, Petershofer E, Dacouris N, Donnelly S, Goldstein MB: The salvage of aneurismal fistulae utilizing a modified buttonhole cannulation technique and multiple cannulators. Hemodial Int 10:193-200, 2006
50. Siegel JD, Rhinehart E, Jackson M, Chiarello L; the Healthcare Infection Control Advisory Committee (HICPAC): Management of multi-drug resistant organisms in healthcare settings, 2006. Available at, accessed May 4, 2011
51. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph A, Rupp ME, Saint S; the Healthcare Infection Control Advisory Committee (HICPAC): Guidelines for the prevention of intravascular catheter-related infections, 2011. Available at, accessed May 4, 2011