Common genetic variants are associated with accelerated bone mineral density loss after hematopoietic cell transplantation

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Yao, Song ^a   Sucheston, Lara E ^a   Smiley, Shannon L ^a   Davis, Warren ^a   Conroy, Jeffrey M ^a   Nowak, Norma J ^a,b   Ambrosone, Christine B ^a   McCarthy, Philip L ^a   Hahn, Theresa ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALLELE; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALOX12 GENE; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BGLAP GENE; BONE AGE; BONE DENSITY; BONE DISEASE; BONE METABOLISM; CLCN7 GENE; COL1A1 GENE; CONTROLLED STUDY; CSF3 GENE; CYP24A1 GENE; ESR1 GENE; FEMALE; FEMUR; FRACTURE; GC GENE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; IL10 GENE; IL1RN GENE; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; NUCLEOTIDE SEQUENCE; OSTEOLYSIS; PHENOTYPE; PROSPECTIVE STUDY; PTH GENE; RANKL GENE; RUNX2 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SPINE; TNFRSF1B GENE; AGED; BIOLOGICAL MODEL; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN GENOME; MIDDLE AGED; RISK FACTOR;

DNA;

ADULT; AGED; ALLELES; BONE DENSITY; DNA; FEMALE; GENETIC VARIATION; GENOME, HUMAN; GENOTYPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 80054678694     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025940     Document Type: Article

References (26)

1. Benjamin RM, (2010) Bone health: preventing osteoporosis. J Am Diet Assoc 110: 498.
2. Kelly PJ, Atkinson K, Ward RL, Sambrook PN, Biggs JC, et al. (1990) Reduced bone mineral density in men and women with allogeneic bone marrow transplantation. Transplantation 50: 881-883.
3. Schulte CM, Beelen DW, (2004) Bone loss following hematopoietic stem cell transplantation: a long-term follow-up. Blood 103: 3635-3643.
4. Tauchmanova L, Serio B, Del Puente A, Risitano AM, Esposito A, et al. (2002) Long-lasting bone damage detected by dual-energy x-ray absorptiometry, phalangeal osteosonogrammetry, and in vitro growth of marrow stromal cells after allogeneic stem cell transplantation. J Clin Endocrinol Metab 87: 5058-5065.
5. Lee WY, Cho SW, Oh ES, Oh KW, Lee JM, et al. (2002) The effect of bone marrow transplantation on the osteoblastic differentiation of human bone marrow stromal cells. J Clin Endocrinol Metab 87: 329-335.
6. Yao S, Smiley SL, West K, Lamonica D, Battiwalla M, et al. (2010) Accelerated bone mineral density loss occurs with similar incidence and severity, but with different risk factors, after autologous versus allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 16: 1130-1137.
7. Peacock M, Turner CH, Econs MJ, Foroud T, (2002) Genetics of osteoporosis. Endocr Rev 23: 303-326.
8. Eisman JA, (1999) Genetics of osteoporosis. Endocr Rev 20: 788-804.
9. Liu YZ, Liu YJ, Recker RR, Deng HW, (2003) Molecular studies of identification of genes for osteoporosis: the 2002 update. J Endocrinol 177: 147-196.
10. Richards JB, Kavvoura FK, Rivadeneira F, Styrkarsdottir U, Estrada K, et al. (2009) Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med 151: 528-537.
11. Kiel DP, Demissie S, Dupuis J, Lunetta KL, Murabito JM, et al. (2007) Genome-wide association with bone mass and geometry in the Framingham Heart Study. BMC Med Genet 8 (Suppl 1): S14.
12. Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N, et al. (2008) Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 371: 1505-1512.
13. Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, et al. (2008) Multiple genetic loci for bone mineral density and fractures. N Engl J Med 358: 2355-2365.
14. Rivadeneira F, Styrkarsdottir U, Estrada K, Halldorsson BV, Hsu YH, et al. (2009) Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet 41: 1199-1206.
15. Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, et al. (2009) New sequence variants associated with bone mineral density. Nat Genet 41: 15-17.
16. Perrone M, (June 01, 2010) FDA clears Amgen's bone-strengthening drug Prolia. Available: http://www.biosciencetechnology.com/News/FeedsAP/2010/06/fda-clears-amgens-bone-strengthening-drug-prolia/ Accessed 2011 September 14.
17. McClune BL, Polgreen LE, Burmeister LA, Blaes AH, Mulrooney DA, et al. (2011) Screening, prevention and management of osteoporosis and bone loss in adult and pediatric hematopoietic cell transplant recipients. Bone Marrow Transplant 46: 1-9.
18. Ambrosone CB, Nesline MK, Davis W, (2006) Establishing a cancer center data bank and biorepository for multidisciplinary research. Cancer Epidemiol Biomarkers Prev 15: 1575-1577.
19. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, et al. (2005) Efficiency and power in genetic association studies. Nat Genet 37: 1217-1223.
20. The International HapMap Consortium (2003) The International HapMap Project. Nature 426: 789-796.
21. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
22. Chen B, Wilkening S, Drechsel M, Hemminki K, (2009) SNP_tools: A compact tool package for analysis and conversion of genotype data for MS-Excel. BMC Res Notes 2: 214.
23. Gamazon ER, Zhang W, Konkashbaev A, Duan S, Kistner EO, et al. (2010) SCAN: SNP and copy number annotation. Bioinformatics 26: 259-262.
24. Murabito JM, Rosenberg CL, Finger D, Kreger BE, Levy D, et al. (2007) A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. BMC Med Genet 8 (Suppl 1): S6.
25. Amling M, Herden S, Posl M, Hahn M, Ritzel H, et al. (1996) Heterogeneity of the skeleton: comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur, and the calcaneus. J Bone Miner Res 11: 36-45.
26. Yao S, McCarthy PL, Dunford LM, Roy DM, Brown K, et al. (2008) High prevalence of early-onset osteopenia/osteoporosis after allogeneic stem cell transplantation and improvement after bisphosphonate therapy. Bone Marrow Transplant 41: 393-398.