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Volumn 39, Issue 4, 2011, Pages 319-336

Computational modeling of airway and pulmonary vascular structure and function: Development of a "lung physiome"

Author keywords

Bronchoconstriction; Multiscale; Perfusion; Respiratory

Indexed keywords

BIOLOGICAL ORGANS; BLOOD VESSELS; COMPUTATION THEORY; FINITE ELEMENT METHOD; TISSUE;

EID: 80054122223     PISSN: 0278940X     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevBiomedEng.v39.i4.50     Document Type: Review
Times cited : (20)

References (93)
  • 1
  • 2
    • 78651150557 scopus 로고
    • Distribution of blood flow in isolated lung; relation to vascular and alveolar pressures
    • West JB, Dollery CT, Naimark A. Distribution of blood flow in isolated lung; relation to vascular and alveolar pressures. J Appl Physiol. 1964;19:713-24.
    • (1964) J Appl Physiol , vol.19 , pp. 713-724
    • West, J.B.1    Dollery, C.T.2    Naimark, A.3
  • 3
    • 0023232950 scopus 로고
    • Theoretical studies of gas mixing and ventilation distribution in the lung
    • Paiva M, Engel LA. Theoretical studies of gas mixing and ventilation distribution in the lung. Physiol Rev. 1987;67(3):750-96.
    • (1987) Physiol Rev , vol.67 , Issue.3 , pp. 750-796
    • Paiva, M.1    Engel, L.A.2
  • 4
    • 27244438288 scopus 로고    scopus 로고
    • Investigation of the relative effects of vascular branching structure and gravity on pulmonary arterial blood flow heterogeneity via an image-based computational model
    • Burrowes KS, Hunter PJ, Tawhai MH. Investigation of the relative effects of vascular branching structure and gravity on pulmonary arterial blood flow heterogeneity via an image-based computational model. Academic Radiol. 2005;12(11):1464-74.
    • (2005) Academic Radiol , vol.12 , Issue.11 , pp. 1464-1474
    • Burrowes, K.S.1    Hunter, P.J.2    Tawhai, M.H.3
  • 5
    • 23044443209 scopus 로고    scopus 로고
    • Anatomicallybased finite element models of the human pulmonary arterial and venous trees including supernumerary vessels
    • Burrowes KS, Hunter PJ, Tawhai MH. Anatomicallybased finite element models of the human pulmonary arterial and venous trees including supernumerary vessels. J Appl Physiol. 2005;99:731-8.
    • (2005) J Appl Physiol , vol.99 , pp. 731-738
    • Burrowes, K.S.1    Hunter, P.J.2    Tawhai, M.H.3
  • 6
    • 33750985100 scopus 로고    scopus 로고
    • Computational predictions of pulmonary blood flow gradients: Gravity versus structure
    • Burrowes KS, Tawhai MH. Computational predictions of pulmonary blood flow gradients: gravity versus structure. Respir Physiol Neurobiol. 2006;154(3):515-23.
    • (2006) Respir Physiol Neurobiol , vol.154 , Issue.3 , pp. 515-523
    • Burrowes, K.S.1    Tawhai, M.H.2
  • 7
    • 77954601280 scopus 로고    scopus 로고
    • Coupling of lung tissue tethering force to fluid dynamics in the pulmonary circulation
    • Burrowes KS, Tawhai MH. Coupling of lung tissue tethering force to fluid dynamics in the pulmonary circulation. Int J Numer Methods Biomed Eng. 2010;26:862-75.
    • (2010) Int J Numer Methods Biomed Eng , vol.26 , pp. 862-875
    • Burrowes, K.S.1    Tawhai, M.H.2
  • 8
    • 34248664406 scopus 로고    scopus 로고
    • Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways
    • Aug 1
    • Lin CL, Tawhai MH, McLennan G, Hoffman EA. Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways. Respir Physiology & Neurobiol. 2007 Aug 1;157(2-3):295-309.
    • (2007) Respir Physiology & Neurobiol , vol.157 , Issue.2-3 , pp. 295-309
    • Lin, C.L.1    Tawhai, M.H.2    McLennan, G.3    Hoffman, E.A.4
  • 9
    • 66249100542 scopus 로고    scopus 로고
    • Computational fluid dynamics: Multiscale simulation of gas flow in subject-specific models of the human lung
    • Lin CL, Tawhai MH, McLennan G, Hoffman EA. Computational fluid dynamics: multiscale simulation of gas flow in subject-specific models of the human lung. IEEE Eng Med Biol. 2009;28(3):25-33.
    • (2009) IEEE Eng Med Biol , vol.28 , Issue.3 , pp. 25-33
    • Lin, C.L.1    Tawhai, M.H.2    McLennan, G.3    Hoffman, E.A.4
  • 10
    • 69749088112 scopus 로고    scopus 로고
    • Supine and prone differences in regional lung density and pleural pressure gradients in the human lung with constant shape
    • Sep
    • Tawhai MH, Nash MP, Lin CL, Hoffman EA. Supine and prone differences in regional lung density and pleural pressure gradients in the human lung with constant shape. J Appl Physiol. 2009 Sep;107(3):912-20.
    • (2009) J Appl Physiol , vol.107 , Issue.3 , pp. 912-920
    • Tawhai, M.H.1    Nash, M.P.2    Lin, C.L.3    Hoffman, E.A.4
  • 14
    • 10944234639 scopus 로고    scopus 로고
    • Integration from proteins to organs: The IUPS Physiome Project
    • Hunter PJ, Smith NP, Fernandez J, Tawhai MH. Integration from proteins to organs: the IUPS Physiome Project. Mech Ageing Dev. 2005;126(1):187-92.
    • (2005) Mech Ageing Dev , vol.126 , Issue.1 , pp. 187-192
    • Hunter, P.J.1    Smith, N.P.2    Fernandez, J.3    Tawhai, M.H.4
  • 17
    • 0025144428 scopus 로고
    • Fractal properties of pulmonary blood flow: Charaterization of spatial heterogeneity
    • Glenny RW, Roberts TJ. Fractal properties of pulmonary blood flow: charaterization of spatial heterogeneity. J Appl Physiol. 1990;69(2):532-45.
    • (1990) J Appl Physiol , vol.69 , Issue.2 , pp. 532-545
    • Glenny, R.W.1    Roberts, T.J.2
  • 18
    • 0026029798 scopus 로고
    • Fractal modeling of pulmonary blood flow heterogeneity
    • Glenny RW, Robertson HT. Fractal modeling of pulmonary blood flow heterogeneity. J Appl Physiol. 1991;70(3):1024-30.
    • (1991) J Appl Physiol , vol.70 , Issue.3 , pp. 1024-1030
    • Glenny, R.W.1    Robertson, H.T.2
  • 19
    • 0032160318 scopus 로고    scopus 로고
    • Comparison of theory and experiment in pulsatile flow in cat lung
    • Huang W, Tian Y, Gao J, Yen RT. Comparison of theory and experiment in pulsatile flow in cat lung. Ann Biomed Eng. 1998;26:812-20.
    • (1998) Ann Biomed Eng , vol.26 , pp. 812-820
    • Huang, W.1    Tian, Y.2    Gao, J.3    Yen, R.T.4
  • 23
    • 0033205531 scopus 로고    scopus 로고
    • Vascular structure determines pulmonary blood flow distribution
    • Hlastala MP, Glenny RW. Vascular structure determines pulmonary blood flow distribution. News Physiol Sci. 1999;14:182-6.
    • (1999) News Physiol Sci , vol.14 , pp. 182-186
    • Hlastala, M.P.1    Glenny, R.W.2
  • 24
    • 33645984858 scopus 로고    scopus 로고
    • Stress transmission in the lung: Pathways from organ to molecule
    • Fredberg JJ, Kamm RD. Stress transmission in the lung: pathways from organ to molecule. Ann Rev Physiol. 2006;68:507-41.
    • (2006) Ann Rev Physiol , vol.68 , pp. 507-541
    • Fredberg, J.J.1    Kamm, R.D.2
  • 25
    • 0036377112 scopus 로고    scopus 로고
    • Endothelial control of vascular tone by nitric oxide and gap junctions: A haemodynamic perspective
    • Griffith TM. Endothelial control of vascular tone by nitric oxide and gap junctions: a haemodynamic perspective. Biorheology. 2002;39(3-4):307-18.
    • (2002) Biorheology , vol.39 , Issue.3-4 , pp. 307-318
    • Griffith, T.M.1
  • 26
    • 70450162884 scopus 로고    scopus 로고
    • MCAT to XCAT: The evolution of 4-D computerized phantoms for imaging research
    • Segars WP, Tsui B. MCAT to XCAT: The evolution of 4-D computerized phantoms for imaging research. Proc IEEE. 2009;97(12):1954-68.
    • (2009) Proc IEEE , vol.97 , Issue.12 , pp. 1954-1968
    • Segars, W.P.1    Tsui, B.2
  • 27
    • 80054103799 scopus 로고    scopus 로고
    • Modeling respiratory motion for cancer radiation therapy based on patient-specific 4DCT data
    • Eom J, Shi C, Xu XG, De S. Modeling respiratory motion for cancer radiation therapy based on patient-specific 4DCT data. Med Image Comput Comput Assist Interv. 2009;12(Pt 2):348-55.
    • (2009) Med Image Comput Comput Assist Interv , vol.12 , Issue.PART 2 , pp. 348-355
    • Eom, J.1    Shi, C.2    Xu, X.G.3    De, S.4
  • 29
    • 65449147454 scopus 로고    scopus 로고
    • Patient-specific finite element modeling of respiratory lung motion using 4D CT image data
    • Werner R, Ehrhardt J, Schmidt R, Handels H. Patient-specific finite element modeling of respiratory lung motion using 4D CT image data. Med Phys. 2009;36:1500-11.
    • (2009) Med Phys , vol.36 , pp. 1500-1511
    • Werner, R.1    Ehrhardt, J.2    Schmidt, R.3    Handels, H.4
  • 30
    • 0022506054 scopus 로고
    • Effect of heart weight on distribution of lung surface pressures in vertical dogs
    • Bar-Yishay E, Hyatt RE, Rodarte JR. Effect of heart weight on distribution of lung surface pressures in vertical dogs. J Appl Physiol. 1986;61(2):712-8.
    • (1986) J Appl Physiol , vol.61 , Issue.2 , pp. 712-718
    • Bar-Yishay, E.1    Hyatt, R.E.2    Rodarte, J.R.3
  • 31
    • 0015420178 scopus 로고
    • Finite element displacement analysis of a lung
    • Matthews FL, West JB. Finite element displacement analysis of a lung. J Biomech. 1972;5: 591-600.
    • (1972) J Biomech , vol.5 , pp. 591-600
    • Matthews, F.L.1    West, J.B.2
  • 32
    • 0015304924 scopus 로고
    • Stresses, strains, and surface pressures in the lung caused by its own weight
    • West JB, Matthews FL. Stresses, strains, and surface pressures in the lung caused by its own weight. J Appl Physiol. 1972;32(3):332-45.
    • (1972) J Appl Physiol , vol.32 , Issue.3 , pp. 332-345
    • West, J.B.1    Matthews, F.L.2
  • 34
    • 0031035760 scopus 로고    scopus 로고
    • Geometric modeling of the human torso using cubic Hermite elements
    • Bradley CP, Pullan AJ, Hunter PJ. Geometric modeling of the human torso using cubic Hermite elements. Ann Biomed Eng. 1997;25:96-111.
    • (1997) Ann Biomed Eng , vol.25 , pp. 96-111
    • Bradley, C.P.1    Pullan, A.J.2    Hunter, P.J.3
  • 36
    • 25444507642 scopus 로고    scopus 로고
    • An anatomically based patient-specific finite element model of patella articulation: Towards a diagnostic tool
    • Fernandez JW, Hunter PJ. An anatomically based patient-specific finite element model of patella articulation: towards a diagnostic tool. Biomech Model Mechanobiol. 2005;4(1):20-38.
    • (2005) Biomech Model Mechanobiol , vol.4 , Issue.1 , pp. 20-38
    • Fernandez, J.W.1    Hunter, P.J.2
  • 37
    • 0037855989 scopus 로고    scopus 로고
    • Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs
    • Nowak N, Kakade PP, Annapragada AV. Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs. Ann Biomed Eng. 2003;31(4):374-90.
    • (2003) Ann Biomed Eng , vol.31 , Issue.4 , pp. 374-390
    • Nowak, N.1    Kakade, P.P.2    Annapragada, A.V.3
  • 38
    • 0012182017 scopus 로고    scopus 로고
    • Swirling steady inspiratory flow in models of human bronchial airways (abstract from BMES annual meeting, RTP 2001)
    • Caro C. Swirling steady inspiratory flow in models of human bronchial airways (abstract from BMES annual meeting, RTP 2001). Ann Biomed Eng. 2001;29(S1):S138.
    • (2001) Ann Biomed Eng , vol.29 , Issue.S1
    • Caro, C.1
  • 41
    • 33845753337 scopus 로고    scopus 로고
    • Flow and particle deposition patterns in a realistic human double bifurcation airway model
    • Choi LT, Tu JY, Li HF, Thien F. Flow and particle deposition patterns in a realistic human double bifurcation airway model. Inhal Toxicol. 2007;19(2):117-31.
    • (2007) Inhal Toxicol , vol.19 , Issue.2 , pp. 117-131
    • Choi, L.T.1    Tu, J.Y.2    Li, H.F.3    Thien, F.4
  • 42
    • 66249100542 scopus 로고    scopus 로고
    • Hoffman EA. Computational fluid dynamics multiscale simulation of gas flow in subject-specific models of the human lung
    • May-Jun
    • Lin CL, Tawhai MH, McLennan G, Hoffman EA. Computational fluid dynamics multiscale simulation of gas flow in subject-specific models of the human lung. IEEE Eng Med Biol. 2009 May-Jun;28(3):25-33.
    • (2009) IEEE Eng Med Biol , vol.28 , Issue.3 , pp. 25-33
    • Lin, C.L.1    Tawhai, M.H.2    McLennan, G.3
  • 43
    • 71049138508 scopus 로고
    • On intra- and intersubject variabilities of airflow in the human lungs
    • 2009 Oct
    • Choi J, Tawhai MH, Hoffman EA, Lin CL. On intra- and intersubject variabilities of airflow in the human lungs. Phys Fluids (1994). 2009 Oct;21(10):101901.
    • (1994) Phys Fluids , vol.21 , Issue.10 , pp. 101901
    • Choi, J.1    Tawhai, M.H.2    Hoffman, E.A.3    Lin, C.L.4
  • 45
    • 78651409338 scopus 로고    scopus 로고
    • The role of airway epithelium in replenishment of evaporated airway surface liquid from the human conducting airways
    • Dec
    • Warren NJ, Crampin EJ, Tawhai MH. The role of airway epithelium in replenishment of evaporated airway surface liquid from the human conducting airways. Ann Biomed Eng. 2010 Dec;38(12): 3535-49.
    • (2010) Ann Biomed Eng , vol.38 , Issue.12 , pp. 3535-3549
    • Warren, N.J.1    Crampin, E.J.2    Tawhai, M.H.3
  • 46
    • 0032795852 scopus 로고    scopus 로고
    • A three-dimensional model of the human airway tree
    • Dec
    • Kitaoka H, Takaki R, Suki B. A three-dimensional model of the human airway tree. J Appl Physiol. 1999 Dec;87(6):2207-17.
    • (1999) J Appl Physiol , vol.87 , Issue.6 , pp. 2207-2217
    • Kitaoka, H.1    Takaki, R.2    Suki, B.3
  • 47
    • 0038790738 scopus 로고
    • The physiological principle of minimum work applied to the angle of branching of arteries
    • Murray CD. The physiological principle of minimum work applied to the angle of branching of arteries. J Gen Physiol. 1926;9:835-41.
    • (1926) J Gen Physiol , vol.9 , pp. 835-841
    • Murray, C.D.1
  • 48
    • 0037518401 scopus 로고    scopus 로고
    • Relation between structure, function, and imaging in a three-dimensional model of the lung
    • Tgavalekos NT, Venegas JG, Suki B, Lutchen KR. Relation between structure, function, and imaging in a three-dimensional model of the lung. Ann Biomed Eng. 2003;31(4):363-73.
    • (2003) Ann Biomed Eng , vol.31 , Issue.4 , pp. 363-373
    • Tgavalekos, N.T.1    Venegas, J.G.2    Suki, B.3    Lutchen, K.R.4
  • 49
    • 0034231008 scopus 로고    scopus 로고
    • Generation of an anatomically based three-dimensional model of the conducting airways
    • Tawhai MH, Pullan AJ, Hunter PJ. Generation of an anatomically based three-dimensional model of the conducting airways. Ann Biomed Eng. 2000;28(7):793-802.
    • (2000) Ann Biomed Eng , vol.28 , Issue.7 , pp. 793-802
    • Tawhai, M.H.1    Pullan, A.J.2    Hunter, P.J.3
  • 51
    • 0024127472 scopus 로고
    • Modeling of lung morphogenesis using fractal geometries
    • Nelson TR, Manchester DK. Modeling of lung morphogenesis using fractal geometries. IEEE Trans Med Imaging. 1988;7(4):321-7.
    • (1988) IEEE Trans Med Imaging , vol.7 , Issue.4 , pp. 321-327
    • Nelson, T.R.1    Manchester, D.K.2
  • 52
    • 0017075511 scopus 로고
    • Diameters, lengths, and branching ratios in the bronchial tree
    • Horsfield K, Relea FG, Cumming G. Diameters, lengths, and branching ratios in the bronchial tree. Respir Physiol. 1976;26(3):351-6.
    • (1976) Respir Physiol , vol.26 , Issue.3 , pp. 351-356
    • Horsfield, K.1    Relea, F.G.2    Cumming, G.3
  • 53
    • 0017873540 scopus 로고
    • Application of an idealized model to morphometry of the mammalian tracheobronchial tree
    • Phalen RF, Yeh HC, Schum GM, Raabe OG. Application of an idealized model to morphometry of the mammalian tracheobronchial tree. Anat Rec. 1978;190:167-76.
    • (1978) Anat Rec , vol.190 , pp. 167-176
    • Phalen, R.F.1    Yeh, H.C.2    Schum, G.M.3    Raabe, O.G.4
  • 54
    • 0003584198 scopus 로고
    • Tracheobronchial geometry: Human, dog, rat, hamster
    • LF-53. Albuquerque, NM: Lovelace Foundation For Medical Education and Research
    • Raabe OG, Yeh H-C, Schum GM, Phalen RF. Tracheobronchial geometry: human, dog, rat, hamster. LF-53. Albuquerque, NM: Lovelace Foundation for Medical Education and Research1976.
    • (1976)
    • Raabe, O.G.1    Yeh, H.-C.2    Schum, G.M.3    Phalen, R.F.4
  • 55
    • 77955282211 scopus 로고    scopus 로고
    • Simulation of pulmonary air flow with a subject-specific boundary condition
    • Aug 10
    • Yin YB, Choi JW, Hoffman EA, Tawhai MH, Lin CL. Simulation of pulmonary air flow with a subject-specific boundary condition. J Biomech. 2010 Aug 10;43(11):2159-63.
    • (2010) J Biomech , vol.43 , Issue.11 , pp. 2159-2163
    • Yin, Y.B.1    Choi, J.W.2    Hoffman, E.A.3    Tawhai, M.H.4    Lin, C.L.5
  • 56
    • 0000309827 scopus 로고
    • Some new facts about the pulmonary artery and its branching pattern
    • Elliot FM, Reid L. Some new facts about the pulmonary artery and its branching pattern. Clin Radiol. 1965;16(3):193-8.
    • (1965) Clin Radiol , vol.16 , Issue.3 , pp. 193-198
    • Elliot, F.M.1    Reid, L.2
  • 57
    • 0033972598 scopus 로고    scopus 로고
    • Shaw A. 5-Hydroxytryptamine- and U46619-mediated vasoconstriction in bovine pulmonary conventional and supernumerary arteries: Effect of endogenous nitric oxide
    • Bunton D, MacDonald A, Brown T, Tracey A, McGrath J, Shaw A. 5-Hydroxytryptamine- and U46619-mediated vasoconstriction in bovine pulmonary conventional and supernumerary arteries: effect of endogenous nitric oxide. Clin Sci. 2000;98:81-9.
    • (2000) Clin Sci , vol.98 , pp. 81-89
    • Bunton, D.1    Macdonald, A.2    Brown, T.3    Tracey, A.4    McGrath, J.5
  • 58
    • 0023951406 scopus 로고
    • Morphometry of the human pulmonary acinus
    • Haefeli-Bleuer B, Weibel ER. Morphometry of the human pulmonary acinus. Anatom Record. 1988;220:401-14.
    • (1988) Anatom Record , vol.220 , pp. 401-414
    • Haefeli-Bleuer, B.1    Weibel, E.R.2
  • 59
    • 0036677448 scopus 로고    scopus 로고
    • Smaller is better--but not too small: A physical scale for the design of the mammalian pulmonary acinus
    • Aug
    • Sapoval B, Filoche M, Weibel ER. Smaller is better--but not too small: a physical scale for the design of the mammalian pulmonary acinus. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10411-6.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.16 , pp. 10411-10416
    • Sapoval, B.1    Filoche, M.2    Weibel, E.R.3
  • 60
    • 0034905956 scopus 로고    scopus 로고
    • Characterising respiratory airway gas mixing using a lumped parameter model of the pulmonary acinus
    • Tawhai MH, Hunter PJ. Characterising respiratory airway gas mixing using a lumped parameter model of the pulmonary acinus. Respir Physiol. 2001;127:241-8.
    • (2001) Respir Physiol , vol.127 , pp. 241-248
    • Tawhai, M.H.1    Hunter, P.J.2
  • 61
    • 0025605022 scopus 로고
    • Model simulations of gas mixing and ventilation distribution in the human lung
    • Verbanck S, Paiva M. Model simulations of gas mixing and ventilation distribution in the human lung. J Appl Physiol. 1990;69(6):2269-79.
    • (1990) J Appl Physiol , vol.69 , Issue.6 , pp. 2269-2279
    • Verbanck, S.1    Paiva, M.2
  • 62
    • 0018190668 scopus 로고
    • Morphometry of the small pulmonary arteries in man
    • May
    • Horsfield K. Morphometry of the small pulmonary arteries in man. Circ Res. 1978 May;42:593-37.
    • (1978) Circ Res , vol.42 , pp. 593-637
    • Horsfield, K.1
  • 63
    • 0013880346 scopus 로고
    • The circulation in the peripheral parts of the human lung
    • Pump KK. The circulation in the peripheral parts of the human lung. Chest. 1966;49(2):119-29.
    • (1966) Chest , vol.49 , Issue.2 , pp. 119-129
    • Pump, K.K.1
  • 64
    • 0014492686 scopus 로고
    • Theory of sheet flow in lung alveoli
    • Fung YC, Sobin SS. Theory of sheet flow in lung alveoli. J Appl Physiol. 1969;26:472-88.
    • (1969) J Appl Physiol , vol.26 , pp. 472-488
    • Fung, Y.C.1    Sobin, S.S.2
  • 65
    • 33745186232 scopus 로고    scopus 로고
    • Vascular impedance analysis in human pulmonary circulation
    • Zhou Q, Gao J, Huang W, Yen M. Vascular impedance analysis in human pulmonary circulation. Biomed Sci Instrum. 2006;42:470-5.
    • (2006) Biomed Sci Instrum , vol.42 , pp. 470-475
    • Zhou, Q.1    Gao, J.2    Huang, W.3    Yen, M.4
  • 66
    • 0020506653 scopus 로고
    • Analysis of blood flow in cat's lung with detailed anatomical and elasticity data
    • Zhuang FY, Fung YC, Yen RT. Analysis of blood flow in cat's lung with detailed anatomical and elasticity data. J Appl Physiol. 1983;55(4):1341-8.
    • (1983) J Appl Physiol , vol.55 , Issue.4 , pp. 1341-1348
    • Zhuang, F.Y.1    Fung, Y.C.2    Yen, R.T.3
  • 67
    • 77951970413 scopus 로고    scopus 로고
    • Contribution of serial and parallel micro-perfusion to spatial variability in pulmonary inter- and intra-acinar blood flow
    • Clark AR, Burrowes KS, Tawhai MH. Contribution of serial and parallel micro-perfusion to spatial variability in pulmonary inter- and intra-acinar blood flow. J Appl Physiol. 2010;108(5):1116-26.
    • (2010) J Appl Physiol , vol.108 , Issue.5 , pp. 1116-1126
    • Clark, A.R.1    Burrowes, K.S.2    Tawhai, M.H.3
  • 68
    • 0014093396 scopus 로고
    • Stratified distribution of blood flow in secondary lobule of the rat lung
    • Wagner P, McRae J, Read J. Stratified distribution of blood flow in secondary lobule of the rat lung. J Appl Physiol. 1967;22(6):1115-23.
    • (1967) J Appl Physiol , vol.22 , Issue.6 , pp. 1115-1123
    • Wagner, P.1    McRae, J.2    Read, J.3
  • 69
    • 0015310114 scopus 로고
    • Effect of stratified inequality of blood flow on gas exchange in liquidfilled lungs
    • West JB, Maloney JE, Castle BL. Effect of stratified inequality of blood flow on gas exchange in liquidfilled lungs. J Appl Physiol. 1972;32(3):357-61.
    • (1972) J Appl Physiol , vol.32 , Issue.3 , pp. 357-361
    • West, J.B.1    Maloney, J.E.2    Castle, B.L.3
  • 70
    • 2442520661 scopus 로고    scopus 로고
    • Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary networ
    • Burrowes KS, Tawhai MH, Hunter PJ. Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary network. Ann Biomed Eng. 2004;32(4):585-95.
    • (2004) Ann Biomed En , vol.32 , Issue.4 , pp. 585-589
    • Burrowes, K.S.1    Tawhai, M.H.2    Hunter, P.J.3
  • 71
    • 0035140679 scopus 로고    scopus 로고
    • Computational modeling of RBC and neutrophil transit through the pulmonary capillaries
    • Huang Y, Doerschuk CM, Kamm RD. Computational modeling of RBC and neutrophil transit through the pulmonary capillaries. J Appl Physiol. 2001;90(2):545-64.
    • (2001) J Appl Physiol , vol.90 , Issue.2 , pp. 545-564
    • Huang, Y.1    Doerschuk, C.M.2    Kamm, R.D.3
  • 72
    • 0030719985 scopus 로고    scopus 로고
    • Effects of anatomic variability on blood flow and pressure gradients in the pulmonary circulation
    • Dhadwal A, Wiggs B, Doerschuk C, Kamm R. Effects of anatomic variability on blood flow and pressure gradients in the pulmonary circulation. J Appl Physiol. 1997;83(5):1711-20.
    • (1997) J Appl Physiol , vol.83 , Issue.5 , pp. 1711-1720
    • Dhadwal, A.1    Wiggs, B.2    Doerschuk, C.3    Kamm, R.4
  • 74
    • 0018398208 scopus 로고
    • Improved measurements of shear modulus and pleural membrane tension of the lung
    • Hajji MA, Wilson TA, Lai-Fook SJ. Improved measurements of shear modulus and pleural membrane tension of the lung. J Appl Physiol. 1979;47:175-81.
    • (1979) J Appl Physiol , vol.47 , pp. 175-181
    • Hajji, M.A.1    Wilson, T.A.2    Lai-Fook, S.J.3
  • 75
    • 0033925746 scopus 로고    scopus 로고
    • Effects of age on elastic moduli of human lungs
    • Lai-Fook SJ, Hyatt RE. Effects of age on elastic moduli of human lungs. J Appl Physiol. 2000;89:163-8.
    • (2000) J Appl Physiol , vol.89 , pp. 163-168
    • Lai-Fook, S.J.1    Hyatt, R.E.2
  • 76
    • 0024244835 scopus 로고
    • Elastic properties of airand liquid-filled lung parenchyma
    • Stamenovic D, Yager D. Elastic properties of airand liquid-filled lung parenchyma. J Appl Physiol. 1988;65(6):2565-70.
    • (1988) J Appl Physiol , vol.65 , Issue.6 , pp. 2565-2570
    • Stamenovic, D.1    Yager, D.2
  • 77
    • 23644436825 scopus 로고    scopus 로고
    • The interface between measurement and modeling of peripheral lung mechanics
    • Bates JHT, Lutchen KR. The interface between measurement and modeling of peripheral lung mechanics. Resp Physiol Neurobiol. 2005;148(1-2):153-64.
    • (2005) Resp Physiol Neurobiol , vol.148 , Issue.1-2 , pp. 153-164
    • Bates, J.H.T.1    Lutchen, K.R.2
  • 78
    • 70349696274 scopus 로고    scopus 로고
    • Sliding characteristic and material compressibility of human lung: Parametric study and verification
    • Oct
    • Al-Mayah A, Moseley J, Velec M, Brock KK. Sliding characteristic and material compressibility of human lung: parametric study and verification. Med Phys. 2009 Oct;36(10):4625-33.
    • (2009) Med Phys , vol.36 , Issue.10 , pp. 4625-4633
    • Al-Mayah, A.1    Moseley, J.2    Velec, M.3    Brock, K.K.4
  • 80
    • 77955601615 scopus 로고    scopus 로고
    • The multiscale manifestations of airway smooth muscle contraction in the lung
    • Bates JHT. The multiscale manifestations of airway smooth muscle contraction in the lung. J Appl Physiol. 2010;109(2):269-70.
    • (2010) J Appl Physiol , vol.109 , Issue.2 , pp. 269-270
    • Bates, J.H.T.1
  • 81
    • 0034878620 scopus 로고    scopus 로고
    • Airway stability and heterogeneity in the constricted lung
    • Anafi RC, Wilson TA. Airway stability and heterogeneity in the constricted lung. J Appl Physiol. 2001;91:1185-92.
    • (2001) J Appl Physiol , vol.91 , pp. 1185-1192
    • Anafi, R.C.1    Wilson, T.A.2
  • 82
    • 33845430769 scopus 로고    scopus 로고
    • New perspectives on the mechanical basis for airway hyperreactivity and airway hypersensitivity in asthma
    • Affonce DA, Lutchen KR. New perspectives on the mechanical basis for airway hyperreactivity and airway hypersensitivity in asthma. J Appl Physiol. 2006;101(6):1710-9.
    • (2006) J Appl Physiol , vol.101 , Issue.6 , pp. 1710-1719
    • Affonce, D.A.1    Lutchen, K.R.2
  • 83
    • 77955633802 scopus 로고    scopus 로고
    • Modeling the dynamics of airway constriction: Effects of agonist transport and binding
    • Amin S, Majumdar A, Frey U, Suki B. Modeling the dynamics of airway constriction: effects of agonist transport and binding. J Appl Physiol. 2010;109(2):553.
    • (2010) J Appl Physiol , vol.109 , Issue.2 , pp. 553
    • Amin, S.1    Majumdar, A.2    Frey, U.3    Suki, B.4
  • 85
    • 33847013578 scopus 로고
    • Muscle structure and theories of contraction
    • Huxley A. Muscle structure and theories of contraction. Prog Biophys Biophys Chem. 1957;7: 255-318.
    • (1957) Prog Biophys Biophys Chem , vol.7 , pp. 255-318
    • Huxley, A.1
  • 86
    • 44049084812 scopus 로고    scopus 로고
    • A mathematical model of airway and pulmonary arteriole smooth muscle
    • Wang I, Politi AZ, Tania N, Bai Y, Sanderson MJ, Sneyd J. A mathematical model of airway and pulmonary arteriole smooth muscle. Biophys J. 2008;94(6):2053-64.
    • (2008) Biophys J , vol.94 , Issue.6 , pp. 2053-2064
    • Wang, I.1    Politi, A.Z.2    Tania, N.3    Bai, Y.4    Sanderson, M.J.5    Sneyd, J.6
  • 87
    • 0023841161 scopus 로고
    • Cross-bridge phosphorylation and regulation of latch state in smooth muscle
    • Hai C, Murphy R. Cross-bridge phosphorylation and regulation of latch state in smooth muscle. Am J Physiol Cell Physiol. 1988;254(1):C99.
    • (1988) Am J Physiol Cell Physiol , vol.254 , Issue.1
    • Hai, C.1    Murphy, R.2
  • 88
    • 0033057083 scopus 로고    scopus 로고
    • Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm
    • Fredberg J, Inouye D, Mijailovich S, Butler J. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med. 1999;159(3): 959-67.
    • (1999) Am J Respir Crit Care Med , vol.159 , Issue.3 , pp. 959-967
    • Fredberg, J.1    Inouye, D.2    Mijailovich, S.3    Butler, J.4
  • 89
    • 70450228407 scopus 로고    scopus 로고
    • Speciesspecific pulmonary arterial asymmetry determines species differences in regional pulmonary perfusion
    • Burrowes KS, Hoffman EA, Tawhai MH. Speciesspecific pulmonary arterial asymmetry determines species differences in regional pulmonary perfusion. Ann Biomed Eng. 2009;37(12):2497-509.
    • (2009) Ann Biomed Eng , vol.37 , Issue.12 , pp. 2497-2509
    • Burrowes, K.S.1    Hoffman, E.A.2    Tawhai, M.H.3
  • 90
    • 57049138345 scopus 로고    scopus 로고
    • Counterpoint: Gravity is not the major factor determining the distribution of blood flow in the healthy human lung
    • Glenny RW. Counterpoint: Gravity is not the major factor determining the distribution of blood flow in the healthy human lung. J Appl Physiol. 2008;104(5):1533-5.
    • (2008) J Appl Physiol , vol.104 , Issue.5 , pp. 1533-1535
    • Glenny, R.W.1
  • 91
    • 0033018875 scopus 로고    scopus 로고
    • Gravity is an important but secondary determinant of regional pulmonary blood flow in upright primates
    • Glenny RW, Bernard S, Robertson HT, Hlastala MP. Gravity is an important but secondary determinant of regional pulmonary blood flow in upright primates. J Appl Physiol. 1999;86(2):623-32.
    • (1999) J Appl Physiol , vol.86 , Issue.2 , pp. 623-632
    • Glenny, R.W.1    Bernard, S.2    Robertson, H.T.3    Hlastala, M.P.4
  • 93
    • 79954578368 scopus 로고    scopus 로고
    • The interdependent contributions of gravitational and structural features to perfusion distribution in a multi-scale model of the pulmonary circulation
    • Clark AR, Tawhai MH, Hoffman EA, Burrowes KS. The interdependent contributions of gravitational and structural features to perfusion distribution in a multi-scale model of the pulmonary circulation. J Appl Physiol. 2011;110(4):943-55.
    • (2011) J Appl Physiol , vol.110 , Issue.4 , pp. 943-955
    • Clark, A.R.1    Tawhai, M.H.2    Hoffman, E.A.3    Burrowes, K.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.