Fecal microbiota transplantation for recurrent Clostridium difficile infection

Journal of Clinical Gastroenterology

Volumn 45, Issue SUPPL. 3, 2011, Pages

  Brandt, Lawrence J ^a,b,c   Reddy, Sheela S ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Division of Gastroenterology   (United States)

^c MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

fecal bacteriotherapy; fecal microbiota transplantation; refractory CDI

Indexed keywords

METRONIDAZOLE; PROBIOTIC AGENT; VANCOMYCIN;

ALTERNATIVE MEDICINE; CLOSTRIDIUM DIFFICILE INFECTION; COLON FLORA; CONFERENCE PAPER; DRUG TREATMENT FAILURE; FECAL MICROBIOTA TRANSPLANTATION; FECES MICROFLORA; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PSEUDOMEMBRANOUS COLITIS; RECURRENT INFECTION;

ADULT; AGED; ANTI-BACTERIAL AGENTS; CHILD, PRESCHOOL; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COLON; ENEMA; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FECES; FEMALE; HUMANS; MALE; METAGENOME; MIDDLE AGED; RECURRENCE; TREATMENT OUTCOME;

EID: 80054111987     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e318222e603     Document Type: Conference Paper

References (69)

1. McDonald LC, Owings M, Jernigan DB. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996 to 2003. Emerg Infect Dis. 2006;12:409-415.
2. Rodemann JF, Dubberke ER, Reske KA, et al. Incidence of Clostridium diffiicile infection in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007;5:339-344.
3. Issa M, Vijayapal A, Graham MB, et al. Impact of Clostridium difficile on inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007;5:345-351.
4. Heinlen L, Ballard JD. Clostridium difficile infection. Am Med Sci. 2010;340:247-252.
5. Bossuyt P, Verhaegen J, Van Assche G, et al. Increasing incidence of Clostridium difficile-associated diarrhea in inflammatory bowel disease. J Crohns Colitis. 2009;3:4-7.
6. Blossom DB, McDonald LC. The challenges posed by reemerging Clostridium difficile infection. Clin Infect Dis. 2007;45:222-227.
7. Surawicz CM, McFarland LV, Greenberg RN, et al. The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin Infect Dis. 2000;31:1012-1017.
8. Leffler DA, Lamont TJ. Treatment of Clostridium difficile-associated disease. Gastroenterology. 2009;136:1899-1912.
9. Lowy I, Molrine DC, Leav BA, et al. Treatment with monoclonal antibodies against Clostridium difficile toxins. N Engl J Med. 2010;362;197-205.
10. Hall IC, O'Toole E. Intestinal flora in new-born infants: with a description of a new pathogenic anaerobe, Bacillus difficilis. Am J Dis Child. 1935;49:390-402.
11. Bartlett JG, Chang TW, Gurwith M, et al. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med. 1978;298:531.
12. Hookman P, Barkin JS. Clostridium difficile associated infection, diarrhea, and colitis. World J Gastroenterol. 2009;15:1554-1580.
13. Bajaj JS, Ananthakrishnan AN, Hafeezullah M, et al. Clostridium difficile is associated with poor outcomes in patients with cirrhosis: a national and tertiary center perspective. Am J Gastroenterol. 2010;105:106-113.
14. Das R, Feuerstadt P, Brandt LJ. Glucocorticoids are associated with increased risk of short term mortality in hospitalized patients with Clostridium difficile-associated disease. Am J Gastroenterol. 2010;105:2040-2049.
15. Ben-Horin S, Margalit M, Bossuyt P, et al. Combination immunomodulator and antibiotic treatment in patients with inflammatory bowel disease and Clostridium difficile infection. Clin Gastroenterol Hepatol. 2009;7:981-987.
16. Zar FA, Bakkanagari SR, Moorthi KM, et al. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis. 2007;45:302-307.
17. Hu MY, Maroo S, Kyne L, et al. A prospective study of risk factors and historical trends in metronidazole failure for Clostridium difficile infection. Clin Gastroenterol Hepatol. 2008;6:1354-1360.
18. Maroo S, Lamont JT. Recurrent Clostridium difficile. Gastroenterology. 2006;130:1311-1316.
19. Grinspan A, Bernheim OE, Yousefzadeh E, et al. Clostridium difficile as a causative agent of post infection irritable bowel syndrome (PI-IBS). Gastroenterology. 2008;134:A91.
20. Wilcox MH, Fawley WN, Settle CD, et al. Recurrence of symptoms in Clostridium difficile infection-relapse or reinfection? J Hosp Infect. 1998;38:93-100.
21. Wong SS, Woo PC, Luk WK, et al. Susceptibility testing of Clostridium difficile against metronidazole and vancomycin by disk diffusion and Etest. Diagn Microbiol Infect Dis. 1999;34:1-6.
22. Lestin F, Pertschy A, Rimek D. Fungemia after oral treatment with Saccharomyces boulardii in a patient with multiple comorbidities. Dtsch Med Wochenschr. 2003;128:2531-2533.
23. Louie TJ, Miller MA, Mullance KM, et al. Fidaxomixin versus vancomycin for Clostridium difficile infection. N Engl J Med. 2011;364:422-431.
24. Louie T, Gerson M, Grimard D, et al. Results of a phase III trial comparing tolevamer, vancomycin, and metronidazole in Clostridium difficile-associated diarrhea (CDAD) (abstract K-425a). In: Program and Abstracts of the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (Chicago, IL). Washington, DC: American Society for Microbiology; 2007.
25. Rager KD, George LW, Hourse JK, et al. Evaluation of rumen transfaunation after surgical correction of left-sided displacement of the abomasum in cows. J Am Vet Med Assoc. 2004;225:915-920.
26. Mair TS. Acute and Chronic Diarrhea. In: Mair TS, Divers TJ, Ducharne NG, eds. Manual of Equine Gastroenterology. London: Elsevier Health Sciences; 2001:431.
27. Grehan MJ, Borody TJ, Leis SM, et al. Durable alteration of the colonic microbiota by the administration of donor fecal flora. J Clin Gastroenterol. 2010;44:551-561.
28. Khoruts A, Sadowsky MJ. Therapeutic transplantation of the distal gut microbiotia. Mucosal Immunol. 2011;4:4-7.
29. Yang F, Polk DB. Commensal bacteria in the gut: learning who our friends are. Curr Opin Gastoenterol. 2004;20:565-571.
30. Hopkins MJ, Macfarlane GT. Changes in predominant bacterial populations in human feces with age and with Clostridium difficile infection. J Med Microbiol. 2002;51:448-454.
31. Chang JY, Antonopoulos DA, Kalra A, et al. Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea. J Infect Dis. 2008;197:435-438.
32. Khoruts A, Dicksved J, Jansson JK, et al. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J Clin Gastroenterol. 2010;44:354-360.
33. Gustafsson A, Lund-Tonnesen S, Berstad A, et al. Fecal shortchain fatty acids in patients with antibiotic-associated diarrhea, before and after fecal enema treatment. Scand J Gastroenterol. 1998;33:721-727.
34. Gustafsson A, Berstad A, Lund-Tonnesen S, et al. The effect of fecal enema on five microflora-associated characteristics in patients with antibiotics associated diarrhea. Scand J Gastroenterol. 1999;34:580-586.
35. Eiseman B, Silen W, Bascom GS, et al. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery. 1958;44:854-859.
36. Collins DC. Pseudomembranous enterocolitis. Further observations on the value of donor fecal enemata as an adjunct in the treatment of pseudomembranous enterocolitis. Am J Proctol. 1960;2:389-391.
37. Fenton S, Stephenson D, Weder C. Pseudomembranous colitis associated with antibiotic therapy-an emerging entity. Can Med Assoc J. 1974;111:1110-1111.
38. Bowden TA, Mansberger AR, Lykins LE. Pseudomembranous enterocolits: mechanism of restoring floral homeostasis. Am Surg. 1981;47:178-183.
39. Schwan A, Sjolin S, Trottestam U. Relapsing Clostridium difficile enterocolitis cured by rectal infusion of homologous feces. Lancet. 1983;2:845.
40. Tvede M, Rask-Madsen J. Bacteriotherapy for chronic relapsing Clostridium difficile diarrhea in six patients. Lancet. 1989;1:1156-1160.
41. Flotterod O, Hopen G. Refractory Clostridium difficile infection: untraditional treatment of antibiotic-induced colitis. Tidsskr Nor Laegeforen. 1991;111:1345-1346.
42. Paterson DL, Irdell J, Whitby M. Putting back the bugs: bacterial treatment relieves chronic diarrhea. Med J Aust. 1994;160:232-233.
43. Lund-Tonnesen S, Berstad A, Schreiner A, et al. Clostridium difficile-associated diarrhea treated with homologous feces. Tidsskr Nor Laegeforen. 1998;118:1027-1030.
44. Persky SE, Brandt LJ. Treatment of recurrent Clostridium difficile-associated diarrhea by adminstration of donated stool directly through a colonscope. Am J Gastroenterol. 2000;95:3283-3285.
45. Faust G, Langelier D, Haddad H, et al. Treatment of recurrent pseudomembranous colitis with stool transplantation: report of six cases. Can J Gastroenterol. 2002;16:A43.
46. Aas J, Gessert CE, Bakken JS. Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin Infect Dis. 2003;36:580-585.
47. Jorup-Ronstrom C, Hakanson A, Perrson AK, et al. Feces culture successful therapy in Clostridium difficile diarrhea. Lakartidningen. 2006;103:3603-3605.
48. Wettstein A, Borody TJ, Leis S, et al. Fecal bacteriotherapy-an effective treatment for relapsing symptomatic Clostridium difficile infection (Abstract no. G-57). In: 15th United European Gastroenterology Week 2007 (France). Austria, Vienna: United European Gastroenterology Federation; 2007.
49. Borody J, Wettstein AR, Leis S, et al. Clostridium difficile complicating inflammatory bowel disease: pre-and posttreatment findings. Gastroenterol. 2008;134(4 suppl 1):A-361.
50. Louie TJ, Louie MR, Krulicki W, et al. Home-based fecal flora infusion to arrest multiply-recurrent Clostridium difficile infection (CDI). In: Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy (Washington DC). Arlington, Virginia: Infectious Disease Society of America; 2008.
51. Nieuwdorp M, van Nood E, Speelman P, et al. Treatment of recurrent Clostridium difficile-associated diarrhea with a suspension of donor feces. Ned Tijdschr Geneeskd. 2008;152:1927-1932.
52. You DM, Franzos MA, Holman RP, et al. Successful treatment of fulminant Clostridium difficile infection with fecal bacteriotherapy. Ann Intern Med. 2008;148:632-633.
53. Hellemans R, Naegels S, Holvoet J. Fecal transplantation for recurrent Clostridium difficile colitis, an underused treatment modality. Acta Gastroenterol Belg. 2009;72:269-270.
54. MacConnachie AA, Fox R, Kennedy DR, et al. Fecal transplant for recurrent Clostridium difficile-associated diarrhea: a UK case series. QJM. 2009;102:781-784.
55. Yoon SS, Brandt LJ. Treatment of refractory/recurrent C. difficile-associated disease by donated stool transplanted via colonoscopy: a case series of 12 patients. J Clin Gastroenterol. 2010;44:562-566.
56. Rohlke F, Surawicz CM, Stollman N. Fecal flora reconstitution for recurrent Clostridium difficile infection: results and methodology. J Clin Gastroenterol. 2010;44:567-570.
57. Silverman MS, Davis I, Pilla DR. Success of self administered home fecal transplantation for chronic Clostridium difficile infection. Clin Gatroenterol Hepatol. 2010;8:471-473.
58. Garborg K, Waagsbo B, Stallemo A, et al. Results of fecal donor instillation therapy for recurrent Clostridium difficile-associated diarrhea. Scand J Infect Dis. 2010;42:857-861.
59. Kelly C, de Leon L. Successful treatment of recurrent Clostridium difficile infection with donor stool administered at colonoscopy: a case series. Am J Gastroenterol 2010;S135:366.
60. Russell G, Kaplan J, Ferraro MJ, et al. Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol. Pediatrics. 2010;126:e239-e242.
61. Borody TJ, Warren EF, Leis SM, et al. Bacteriotherapy using fecal flora: toying with human motions. J Clin Gastroenterol. 2004;38:475-483.
62. Thanjan AJ, Southern W, Anand N, et al. Is Clostridium difficile infection (CDI) more difficult to eradicate in patients with diverticulosis? Am J Gastroenterol. 2008;103:A504. (S195).
63. van Nood E, Speelman P, Kuijper EJ, et al. Struggling with recurrent Clostridium difficile infections: is donor feces the solution? Euro Surveill. 2009;14. pii: 19316.
64. Bennet JD, Brinkman M. Treatment of ulcerative colitis by implantation of normal colonic flora. Lancet. 1989;1:164.
65. Borody TJ, George L, Andrews PJ et al. Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome? Med J Aust. 1989;150:604.
66. Andrews PJ, Borody TJ. Putting back the bugs: bacterial treatment relieves chronic constipation and symptoms of irritable bowel syndrome. Med J Aust. 1993;159:633-634.
67. Andrews PJ, Barnes P, Borody TJ, et al. Chronic constipation reversed by restoration of bowel flora. A case and a hypothesis. Eur J Gastroenterol Hepatol. 1992;4:245-247.
68. Pimentel M, Lin HC, Enayati P, et al. Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1089-G1095.
69. Borody TJ, Warren EF, Leis S, et al. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol. 2003;37:42-47.