Compartmental modelling of the pharmacokinetics of a breast cancer resistance protein

Computer Methods and Programs in Biomedicine

Volumn 104, Issue 2, 2011, Pages 81-92

  Grandjean, Thomas R B ^a   Chappell, Mike J ^a   Yates, James T W ^b   Jones, Kevin ^b   Wood, Gemma ^b   Coleman, Tanya ^b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Breast cancer resistance protein (BCRP); Compartmental models; Drug kinetics

Indexed keywords

ASTRA ZENECA; BREAST CANCER RESISTANCE PROTEINS; COMPARTMENTAL MODEL; COMPARTMENTAL MODELLING; CULTURE MEDIUM; DIFFERENTIAL ALGEBRAS; DRUG KINETICS; HEK-293; HOECHST; IN-VITRO; KINETIC MODELLING; MODEL FIT; NON-LINEAR; NUMERICAL SOLUTION; PARAMETER FITTING; RATE PARAMETERS; SIMILARITY TRANSFORMATION; STRUCTURAL IDENTIFIABILITY; SUB-UNITS; SYSTEM EQUATIONS; TRANSFECTED CELLS;

CELL CULTURE; DISEASES; MATHEMATICAL MODELS; PHARMACOKINETICS;

PROTEINS;

BREAST CANCER RESISTANCE PROTEIN; CELL DNA; FUMITREMORGIN C; HOE 33342;

ARTICLE; CELL STRAIN HEK293; CELL TRANSPORT; COMPARTMENT MODEL; COMPUTER PROGRAM; CONCENTRATION (PARAMETERS); CULTURE MEDIUM; DNA BINDING; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; STEADY STATE; STRUCTURE ANALYSIS;

ATP-BINDING CASSETTE TRANSPORTERS; FEMALE; HUMANS; INDOLES; MODELS, THEORETICAL; NEOPLASM PROTEINS;

EID: 80054110298     PISSN: 01692607     EISSN: 18727565     Source Type: Journal    
DOI: 10.1016/j.cmpb.2010.08.018     Document Type: Article

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