Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling

Mathematical Biosciences

Volumn 213, Issue 2, 2008, Pages 119-134

  Cheung, S Y Amy ^a   Evans, Neil D ^b   Chappell, Michael J ^b   Godfrey, Keith R ^b   Smith, Paul J ^c   Errington, Rachel J ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Compartmental models; Drug kinetics; Structural identifiability; Topotecan

Indexed keywords

CELL CULTURE; MATHEMATICAL MODELS; PARAMETER ESTIMATION; PHOTONS;

COMPARTMENTAL MODELS; DRUG KINETICS; STRUCTURAL IDENTIFIABILITY;

TUMORS;

TOPOTECAN;

CANCER; CELL ORGANELLE; DRUG; HETEROGENEITY; LASER; SOFTWARE;

ARTICLE; BREAST CANCER; CELL HETEROGENEITY; CELL TYPE; COMPARTMENT MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; CULTURE MEDIUM; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; NONLINEAR SYSTEM;

BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; HUMANS; HYDROLYSIS; KINETICS; LEAST-SQUARES ANALYSIS; MATHEMATICAL COMPUTING; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; SOFTWARE; TOPOTECAN;

EID: 44649140392     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mbs.2008.03.008     Document Type: Article

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