Effects of PROG treatment on neuronal apoptosis in Aβ25-35 induced AD model

Chinese Pharmacological Bulletin

Volumn 27, Issue 8, 2011, Pages 1152-1156

  Yu, Yang ^a,b   Hou, Yan Ning ^a,b   Wu, Hong Hai ^a   Xue, Gai ^a   Wei, Ji Chao ^a,b  

^a BETHUNE INTERNATIONAL PEACE HOSPITAL   (China)

^b HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Apoptosis; Cortical neurons; Neurotoxicity; Progesterone

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; CASPASE 3; PROGESTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN NERVE CELL; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; MORPHOMETRICS; NONHUMAN; RAT; WESTERN BLOTTING;

EID: 80054094823     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1001-1978.2011.08.028     Document Type: Article

References (19)

1. A receptor are regulated by progesterone in subfields of the hippocampus[J]. J Mol Brain Res, 1995, 32(2):271-8.
2. Asbury E T, Fritts M E, Horton J E, et al. Progesterone facilitates the accusation of avoidance learning and protects against subcortical neuronal death following prefrontal cortex ablation in the rat [J]. Behav Brain Res, 1998, 97(1-2):99-106.
3. Reyna N A, Camacho-Arroyo I, Ferrera P, et al. Estradiol and progesterone modify microtubule associated protein 2 content in the rat hippocampus[J]. Brain Res Bull, 2002, 58(6):607-12.
4. Kaur P, Jodhka P K, Underwood W A, et al. Progesterone increase brain-derived neurotrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants[J]. J Neurosci Res, 2007, 85(11):2441-9.
5. Pluchino N, Cubeddu A, Giannini A, et al. Progestogens and brain: an update[J]. Maturitas, 2009, 62(4):340-55
6. Hardy J A, Higgins D A. Alzheimer's disease: the amyloid cascade hypothesis[J]. Science, 1992, 256: 184-5.
7. Yan H, Tang X C. Metabolism and regulation of β-amyloid: a potential target for Alzheimer therapy[J]. Chin Bull Life Sci, 2007, 19(4):409-16.
8. Wojtal K, Trojnar M K, Czuczwar S J. Endogenous neuroprotective factors: neurosteroids[J]. Pharmacol Rep, 2006, 58(3): 335-40.
9. 23-35 on neurosteroidogenesis in primary rat cortical neurons[J]. Chin Pharmacol Bull, 2010, 26(6):783-6.
10. 25-35 induced neuronal toxicity[J]. Chin Hosp Pharm J, 2011, 31(8):666-9.
11. Jiang P. Study of the regulatory effect and the molecular mechanism of morphine on the neurosteroidogensis of rat cerebral cortical nerve cells [D]. Doctor, Shijiazhuang: Hebei Medical University, 2005.
12. Pimplikar SW. A beta PP: apoptosis and Alzheimer's disease[J]. J Alzheimers Dis, 2002, 4(1):39-40.
13. Hoozemans J J, Veerhuis R, Rozemnller A J, et al. The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications[J]. Drug Today, 2002, 38(6):429-43.
14. Shimohama S. Apoptosis in Alzheimer's disease - an update[J]. Apoptosis, 2000, 5(1):9-16.
15. Lassamann H, Bancher C, Breitschopf H, et al. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ[J]. Acta Neuropathol Berl, 1995, 89(1):35-41.
16. Baxa D M, Luo X, Yoshimura F K. Genistein induces apoptosis in T lymphoma cells via mitochondrial damage[J]. Nutr Cancer, 2005, 51(1):93-101.
17. Robert W, Nicole G, Elisabeth G, Manfred W. Two color, fluorescence based microplate assay for apoptosis detection [J]. Biotechniques, 2002, 32(3):666-8.
18. Lekiewicz M, Jantas D, Budziszewska B, Lason W. Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons[J]. J Physiol Pharmacol, 2008, 59(3):457-75.
19. Thornberry N A, Lazebnik Y. Caspase: enemies within[J]. Scicence, 1998, 281(5381):1312-6