Effects of anti-adhesive therapy on kidney biomarkers of ischemia reperfusion injury in human deceased donor kidney allografts

Clinical Transplantation

Volumn 25, Issue 5, 2011, Pages 766-775

  Cheadle, Chris ^a   Watkins, Tonya ^a   Ehrlich, Eva ^a   Barnes, Kathleen ^b   Osama Gaber, A ^c   Hemmerich, Stefan ^d   Rabb, Hamid ^b  

^a Lowe Family Genomics Core ^*  (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c HOUSTON METHODIST HOSPITAL   (United States)

^d Y's Therapeutics   (United States)

Author keywords

Biomarkers; Clinical trial; Ischemia reperfusion injury; Kidney transplant; Selectins

Indexed keywords

BIOLOGICAL MARKER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HYBRID PROTEIN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACEBO; RECOMBINANT P SELECTIN GLYCOPROTEIN LIGAND IMMUNOGLOBULIN G FUSION PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HOUSEKEEPING GENE; HUMAN; INTENTION TO TREAT ANALYSIS; ISCHEMIA REPERFUSION INJURY; KIDNEY BIOPSY; KIDNEY DONOR; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; BIOLOGICAL MARKERS; CADAVER; COHORT STUDIES; CYTOKINES; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; P-SELECTIN; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECOMBINANT FUSION PROTEINS; REPERFUSION; REPERFUSION INJURY; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 80054092092     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2010.01365.x     Document Type: Article

References (42)

1. Patel SJ, Duhart BT Jr, Krauss AG et al. Risk factors and consequences of delayed graft function in deceased donor renal transplant patients receiving antithymocyte globulin induction. Transplantation 2008: 86: 313.
2. Tilney NL, Guttmann RD. Effects of initial ischemia/reperfusion injury on the transplanted kidney. Transplantation 1997: 64: 945.
3. Boros P, Bromberg JS. New cellular and molecular immune pathways in ischemia/reperfusion injury. Am J Transplant 2006: 6: 652.
4. Jang HR, Rabb H. The innate immune response in ischemic acute kidney injury. Clin Immunol 2009: 130: 41.
5. Gjertson DW. Impact of delayed graft function and acute rejection on kidney graft survival. In: Cecka JM, Terasaki PI eds. Clinical Transplants. Los Angeles: UCLA Immunogenetics Center, 2001: 467-480.
6. Gjertson DW, Cecka JM. Determinants of long-term survival of pediatric kidney grafts reported to the United Network for Organ Sharing kidney transplant registry. Pediatr Transplant 2001: 5: 5.
7. Gasser M, Waaga AM, Kist-Van Holthe JE et al. Normalization of brain death-induced injury to rat renal allografts by recombinant soluble P-selectin glycoprotein ligand. J Am Soc Nephrol 2002: 13: 1937.
8. Gasser M, Waaga-Gasser AM, Grimm MW et al. Selectin blockade plus therapy with low-dose sirolimus and cyclosporin a prevent brain death-induced renal allograft dysfunction. Am J Transplant 2005: 5(4 Pt 1): 662.
9. Nemoto T, Burne MJ, Daniels F et al. Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure. Kidney Int 2001: 60: 2205.
10. Takada M, Nadeau KC, Shaw GD, Marquette KA, Tilney NL. The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand. J Clin Invest 1997: 99: 2682.
11. Goes N, Urmson J, Ramassar V, Halloran PF. Ischemic acute tubular necrosis induces an extensive local cytokine response. Evidence for induction of interferon-gamma, transforming growth factor-beta 1, granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-10. Transplantation 1995: 59: 565.
12. Kusaka M, Nadeau KC, Takada M, Nagano H, Shaw GD, Tilney NL. Influence of initial antigen-independent events on acute allograft rejection: inhibition by a soluble P-selectin ligand and low-dose cyclosporine in combination. Transplant Proc 1998: 30: 1027.
13. Singbartl K, Green SA, Ley K. Blocking P-selectin protects from ischemia/reperfusion-induced acute renal failure. FASEB J 2000: 14: 48.
14. McEver RP, Cummings RD. Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest 1997: 100(11 Suppl): S97.
15. Singbartl K, Forlow SB, Ley K. Platelet, but not endothelial, P-selectin is critical for neutrophil-mediated acute postischemic renal failure. FASEB J 2001: 15: 2337.
16. Amersi F, Buelow R, Kato H et al. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J Clin Invest 1999: 104: 1631.
17. Farmer DG, Anselmo D, Da Shen X et al. Disruption of P-selectin signaling modulates cell trafficking and results in improved outcomes after mouse warm intestinal ischemia and reperfusion injury. Transplantation 2005: 80: 828.
18. Farmer DG, Shen XD, Amersi F et al. CD62 blockade with P-Selectin glycoprotein ligand-immunoglobulin fusion protein reduces ischemia-reperfusion injury after rat intestinal transplantation. Transplantation 2005: 79: 44.
19. Gaber AO, Banica M, Cheung P et al. Rapid cytoprotective and anti-inflammatory effect of YSPSL (rPSGL-Ig) in a renal injury model. American Transplant Congress 2007. San Francisco, CA; 2007.
20. Avihingsanon Y, Ma N, Pavlakis M et al. On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes. J Am Soc Nephrol 2005: 16: 1542.
21. Gaber AO, Mulgaonkar S, Kahan BD et al. YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center phase IIa study. Clin Transplant 2010; in press.
22. Kaminska D, Tyran B, Mazanowska O et al. Cytokine gene expression in kidney allograft biopsies after donor brain death and ischemia-reperfusion injury using in situ reverse-transcription polymerase chain reaction analysis. Transplantation 2007: 84: 1118.
23. Araki M, Fahmy N, Zhou L et al. Expression of IL-8 during reperfusion of renal allografts is dependent on ischemic time. Transplantation 2006: 81: 783.
24. Cugini D, Azzollini N, Gagliardini E et al. Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion. Kidney Int 2005: 67: 1753.
25. Burne-Taney MJ, Yokota N, Rabb H. Persistent renal and extrarenal immune changes after severe ischemic injury. Kidney Int 2005: 67: 1002.
26. Rice JC, Spence JS, Yetman DL, Safirstein RL. Monocyte chemoattractant protein-1 expression correlates with monocyte infiltration in the post-ischemic kidney. Ren Fail 2002: 24: 703.
27. Singbartl K, Ley K. Protection from ischemia-reperfusion induced severe acute renal failure by blocking E-selectin. Crit Care Med 2000: 28: 2507.
28. Ollinger R, Kogler P, Biebl M et al. Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function. Clin Transplant 2008: 22: 418.
29. Docherty NG, Perez-Barriocanal F, Balboa NE, Lopez-Novoa JM. Transforming growth factor-beta1 (TGF-beta1): a potential recovery signal in the post-ischemic kidney. Ren Fail 2002: 24: 391.
30. Liu M, Chien CC, Grigoryev DN, Gandolfo MT, Colvin RB, Rabb H. Effect of T cells on vascular permeability in early ischemic acute kidney injury in mice. Microvasc Res 2009: 77: 340.
31. Kinsey GR, Huang L, Vergis AL, Li L, Okusa MD. Regulatory T cells contribute to the protective effect of ischemic preconditioning in the kidney. Kidney Int 2010: 77: 771.
32. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001: 25: 402.
33. Irish WD, McCollum DA, Tesi RJ et al. Nomogram for predicting the likelihood of delayed graft function in adult cadaveric renal transplant recipients. J Am Soc Nephrol 2003: 14: 2967.
34. Humar A, Ramcharan T, Kandaswamy R, Gillingham K, Payne WD, Matas AJ. Risk factors for slow graft function after kidney transplants: a multivariate analysis. Clin Transplant 2002: 16: 425.
35. Pratschke J, Weiss S, Neuhaus P, Pascher A. Review of nonimmunological causes for deteriorated graft function and graft loss after transplantation. Transpl Int 2008: 21: 512.
36. Katori M, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 system in organ transplantation. Transplantation 2002: 74: 905.
37. Anraku M, Cameron MJ, Waddell TK et al. Impact of human donor lung gene expression profiles on survival after lung transplantation: a case-control study. Am J Transplant 2008: 8: 2140.
38. Allanach K, Mengel M, Einecke G et al. Comparing microarray versus RT-PCR assessment of renal allograft biopsies: similar performance despite different dynamic ranges. Am J Transplant 2008: 8: 1006.
39. Ascon DB, Lopez-Briones S, Liu M et al. Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury. J Immunol 2006: 177: 3380.
40. Jang HR, Ko GJ, Wasowska BA, Rabb H. The interaction between ischemia-reperfusion and immune responses in the kidney. J Mol Med 2009: 87: 859.
41. Singh I, Zibari GB, Brown MF et al. Role of P-selectin expression in hepatic ischemia and reperfusion injury. Clin Transplant 1999: 13(1 Pt 2): 76.
42. Zizzi HC, Zibari GB, Granger DN et al. Quantification of P-selectin expression after renal ischemia and reperfusion. J Pediatr Surg 1997: 32: 1010.