Stereospecific total syntheses of proteasome inhibitors omuralide and lactacystin

Journal of Organic Chemistry

Volumn 76, Issue 20, 2011, Pages 8287-8293

  Gu, Wenxin ^a   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTACYSTIN; NATURAL PRODUCTS; PROTEASE ACTIVITIES; PROTEASOME INHIBITORS; PROTEASOMES; PROTEOLYTIC ACTIVITIES; SPECIFIC INHIBITORS; STEREOSPECIFIC; TOTAL SYNTHESIS; TRANSFORMATION PRODUCTS;

METABOLITES;

CARBOXYLIC ACID DERIVATIVE; LACTACYSTIN; LACTACYSTIN BETA LACTONE; METHYL 3 (TERT BUTYLDIMETHYLSILYLOXY) 2 FORMYL 1 (4 METHOXYBENZYL) 5 OXOPYRROLIDINE 2 CARBOXYLATE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; DIECKMANN REACTION; REDUCTION; STEREOCHEMISTRY; STEREOSPECIFICITY; SYNTHESIS; TOTAL SYNTHESIS;

ACETYLCYSTEINE; APOPTOSIS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; HUMANS; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASMS; PROTEASOME ENDOPEPTIDASE COMPLEX; STEREOISOMERISM;

EID: 80054092090     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201453x     Document Type: Article

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