Severe controlled hemorrhage resuscitation with small volume poloxamer 188 in sedated miniature swine

Resuscitation

Volumn 82, Issue 11, 2011, Pages 1453-1459

  Burns, John W ^a   Baer, Lisa A ^a   Jones, John A ^a   Dubick, Michael A ^a   Wade, Charles E ^a  

^a US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

60 hemorrhage; Coagulopathy; Hypotension; Metabolic acidosis; Surfactant; Survival; Thromboelastogram (TEG)

Indexed keywords

FLOCOR; POLOXAMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD VOLUME; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; HUMAN; HUMAN TISSUE; MALE; MINIPIG; NONHUMAN; PRIORITY JOURNAL; RESUSCITATION; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME;

ANIMALS; DEEP SEDATION; HEMORRHAGE; HYPOVOLEMIA; MALE; POLOXAMER; RESUSCITATION; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; SWINE; SWINE, MINIATURE;

EID: 80054088412     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2011.06.007     Document Type: Article

References (30)

1. Skarda D.E., Mulier K.E., George M.E., Bellman G.J. Eight hours of hypotensive versus normotensive resuscitation in a porcine model of controlled hemorrhagic shock. Acad Emerg Med 2008, 15:845-852.
2. Stern S.A., Dronen S.C., Birrer P., Wang X. Effect of blood pressure on hemorrhage volume and survival in a near-fatal hemorrhage model incorporating a vascular injury. Ann Emerg Med 1993, 22:155-163.
3. Haas T., Fries D., Holz C., et al. Less impairment of hemostasis and reduced blood loss in pigs after resuscitation from hemorrhagic shock using the small-volume concept with hypertonic saline/hydroxyethyl starch as compared to administration of 4% gelatin or 6% hydroxyethyl starch solution. Anesth Analg 2008, 106:1078-1086.
4. Holcomb J.B. Fluid resuscitation in modern combat casualty care: lessons learned from Somalia. J Trauma 2003, 54:S46-S51.
5. Watters J.M., Tieu B.H., Differding J.A., Muller P.J., Schreiber M.A. A single bolus of 3% hypertonic saline with 6% dextran provides optimal initial resuscitation after uncontrolled hemorrhagic shock. J Trauma 2006, 61:75-81.
6. Burns J.W., Baer L.A., Hagerman E.J., et al. Development and resuscitation of a sedated mature male miniature swine severe hemorrhage model. J Trauma 2010, [Epub ahead of print].
7. Orringer E.P., Casella J.F., Ataga K.I., et al. Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: a randomized controlled trial. JAMA 2001, 286:2099-2106.
8. Egan J.R., Butler T.L., Cole A.D., et al. Myocardial membrane injury in pediatric cardiac surgery: an animal model. J Thorac Cardiovasc Surg 2009, 137:1154-1162.
9. Townsend D., Yasuda S., Metzger J. Cardiomyopathy of Duchenne muscular dystrophy: pathogenesis and prospect of membrane sealants as a new therapeutic approach. Expert Rev Cardiovasc Ther 2007, 5:99-109.
10. Yasuda S., Townsend D., Michele D.E., Favre E.G., Day S.M., Metzger J.M. Dystrophic heart failure blocked by membrane sealant poloxamer. Nature 2005, 436:1025-1029.
11. Justicz A.G., Farnsworth W.V., Soberman M.S., et al. Reduction of myocardial infarct size by poloxamer 188 and mannitol in a canine model. Am Heart J 1991, 122:671-680.
12. Mezrow C.K., Mazzoni M., Wolfe D., Shiang H.H., Litwak R.S., Griepp R.B. Poloxamer 188 improves neurologic outcome after hypothermic circulatory arrest. J Thorac Cardiovasc Surg 1992, 103:1143-1146.
13. Grover F.L., Amundsen D., Warden J.L., Fosburg R.G., Paton B.C. The effect of pluronic F-68 on circulatory dynamics and renal and carotid artery flow during hemorrhagic shock. J Surg Res 1974, 17:30-35.
14. Hymes A.C., Safavian M.H., Gunther T. The influence of an industrial surfactant pluronic F-68, in the treatment of hemorrhagic shock. J Surg Res 1971, 11:191-197.
15. Mayer D.C., Strada S.J., Hoff C., Hunter R.L., Artman M. Effects of poloxamer 188 in a rabbit model of hemorrhagic shock. Ann Clin Lab Sci 1994, 24:302-311.
16. Zhang R., Hunter R.L., Gonzalez E.A., Moore F.A. Poloxamer 188 prolongs survival of hypotensive resuscitation and decreases vital tissue injury after full resuscitation. Shock 2009, 32:442-450.
17. Grindel J.M., Jaworski T., Piraner O., Emanuele R.M., Balasubramanian M. Distribution, metabolism, and excretion of a novel surface-active agent, purified poloxamer 188, in rats, dogs, and humans. J Pharm Sci 2002, 91:1936-1947.
18. Schmidlin D., Hager P., Schmid E.R. Monitoring level of sedation with bispectral EEG analysis: comparison between hypothermic and normothermic cardiopulmonary bypass. Br J Anaesth 2001, 86:769-776.
19. Hannon J.P., Wade C.E., Bossone C.A., Hunt M.M., Loveday J.A. Oxygen delivery and demand in conscious pigs subjected to fixed-volume hemorrhage and resuscitated with 7.5% NaCl in 6% Dextran. Circ Shock 1989, 29:205-217.
20. Wang P., Ba Z.F., Reich S.S., Zhou M., Holme K.R., Chaudry I.H. Effects of nonanticoagulant heparin on cardiovascular and hepatocellular function after hemorrhagic shock. Am J Physiol 1996, 270:H1294-H1302.
21. Baskaran H., Toner M., Yarmush M.L., Berthiaume F. Poloxamer-188 improves capillary blood flow and tissue viability in a cutaneous burn wound. J Surg Res 2001, 101:56-61.
22. Ng R., Metzger J.M., Claflin D.R., Faulkner J.A. Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from mdx mice. Am J Physiol Cell Physiol 2008, 295:C146-C150.
23. Schreiber M.A., Differding J., Thorborg P., Mayberry J.C., Mullins R.J. Hypercoagulability is most prevalent early after injury and in female patients. J Trauma 2005, 58:475-480. [Discussion 480-471].
24. Lippi G., Cervellin G. Disseminated intravascular coagulation in trauma injuries. Semin Thromb Hemost 2010, 36:378-387.
25. Emanuele R.M. FLOCOR: a new anti-adhesive, rheologic agent. Expert Opin Invest Drugs 1998, 7:1193-1200.
26. Lechmann T., Reinhart W.H. The non-ionic surfactant poloxamer 188 (RheothRx) increases plasma and whole blood viscosity. Clin Hemorheol Microcirc 1998, 18:31-36.
27. Nalbandian R., Hymes A., Henry R. Effect of pluronic F-68 on blood coagulation. Bull Path 1969, 10:90.
28. Sakai T., Repko B.M., Griffith B.P., Waters J.H., Kameneva M.V. I.V. infusion of a drag-reducing polymer extracted from aloe vera prolonged survival time in a rat model of acute myocardial ischaemia. Br J Anaesth 2007, 98:23-28.
29. Cotoia A., Kameneva M.V., Marascalco P.J., Fink M.P., Delude R.L. Drag-reducing hyaluronic acid increases survival in profoundly hemorrhaged rats. Shock 2009, 31:258-261.
30. Halbmayer W.M., Haushofer A., Schon R., et al. The prevalence of moderate and severe FXII (Hageman factor) deficiency among the normal population: evaluation of the incidence of FXII deficiency among 300 healthy blood donors. Thromb Haemost 1994, 71:68-72.