The non-ionic surfactant poloxamer 188 (RheothRx®) increases plasma and whole blood viscosity

Clinical Hemorheology and Microcirculation

Volumn 18, Issue 1, 1998, Pages 31-36

  Lechmann, Th ^a   Reinhart, W H ^a  

^a KANTONSSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

POLOXAMER; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOT LYSIS; BLOOD VISCOSITY; ERYTHROCYTE; HEART INFARCTION; SHEAR RATE; VISCOMETER;

ADULT; BLOOD VISCOSITY; FEMALE; HUMANS; MALE; PLASMA; POLOXALENE; SURFACE-ACTIVE AGENTS;

EID: 0031800578     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. D. Babbitt, M. Forman, R. Jones, A. Bajaj and R. Hoover, Prevention of neutrophil-mediated injury to endothelial cells by perfluorochemical, Ain. J. Patliol. 136 (1990), 451-59.
2. A. Bajaj, M. Cobb, R. Virmani, J. Gay, R. Light and M. Forman, Limitation of myocardial reperfusion injury by intravenous perfluoro-chemicals. Role of neutrophil activation, Circulation 79 (1989), 645-656.
3. K. Benner, P. Gaehtgens and K. Frede, Aggregation of human red blood cells and platelets and its reversal by a surface-active substance (Pluronic F-68®), Bibl. Anat. 12 (1973), 208- 215.
4. M. Carr, P. Powers and M. Jones, Effects of Poloxamer 188 on the assembly, structure and dissolution of fibrin clots, Thromb. Haemostasis 66 (1991), 565-568.
5. C. Carter, T. Fisher, H. Hamai, C. Johnson, H.J. Meiselman, G. Nash and J. Stuart, Haemorheological effects of a nonionic copolymer surfactant (Poloxamer 188), Clin. Hemorheol. 12 (1992), 109-120.
6. S. Chien, Biophysical behavior of red cells in suspensions, in: The Red Blood Cell, McN. Surgenor, ed., 2nd edn, Academic Press, New York, 1975, pp. 1031-1133.
7. H. Colbassani, D. Barrow, K. Sweeney, R. Bakay, I. Check and R. Hunter, Modification of acute focal ischemia in rabbits by Poloxamer 188, Stroke 20 (1989), 1241-1246.
8. Collaborative Organization for RheothRx Evaluation (CORE), Effects of RheothRx on mortality, morbidity, left ventricular function, and infarct size in patients with acute myocardial infarction, Circulation 96 (1997), 192-201.
9. M. Forman, D. Ingram and J. Murray, Attenuation of myocardial reperfusion injury by perfluorochemical emulsions, Clin. Hemorheol. 12 (1992), 121-140.