Cardiac troponin testing in the acute care setting: Ordering, reporting, and high sensitivity assays-An update from the Canadian society of clinical chemists (CSCC)

Clinical Biochemistry

Volumn 44, Issue 16, 2011, Pages 1273-1277

  Kavsak, Peter A ^a,b   Allen, Lynn C ^c   Apple, Fred S ^d   Booth, Ronald A ^e   Chan, Pak Cheung ^c,f   Delvin, Edgard ^g   Fraser, Albert ^h,i   Fu, Lei ^c,f   Gornall, Douglas ^j   Collier, Christine ^w   Hill, Stephen ^a,b   Hoffman, Barry ^c,k   Huang, Yun ^l   Lavoie, Joël ^m   Lou, Amy ⁿ   Mattman, Andre ^o   McQueen, Matthew ^a,b   Meng, Qing H ^p   Oleschuk, Curtis ^q,r   Pudek, Morris ^o,s   Randell, Edward ^t   Sohn, Kun Young ^u   Thorlacius, Laurel ^q,r   Yip, Paul M ^c,v   Dahdah, Nagib ^g   Devereaux, P J ^b   Dhesy Thind, Sukhbinder ^b   Hotte, Sebastien J ^b   Worster, Andrew ^b   more..

^a HAMILTON REGIONAL LABORATORY MEDICINE PROGRAM   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF OTTAWA   (Canada)

^f SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^g UNIVERSITY OF MONTREAL   (Canada)

^h SAINT JOHN REGIONAL HOSPITAL   (Canada)

ⁱ DALHOUSIE UNIVERSITY   (Canada)

^j TORONTO EAST GENERAL HOSPITAL   (Canada)

^k MOUNT SINAI HOSPITAL   (Canada)

^l Clearstone Central Laboratories   (Canada)

^m MONTREAL HEART INSTITUTE   (Canada)

ⁿ Prince Edward Island   (Canada)

^o UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^p ROYAL UNIVERSITY HOSPITAL   (Canada)

^q Diagnostic Services of Manitoba Inc   (Canada)

^r UNIVERSITY OF MANITOBA   (Canada)

^s VANCOUVER GENERAL HOSPITAL   (Canada)

^t MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^u CREDIT VALLEY HOSPITAL   (Canada)

^v UNIVERSITY HEALTH NETWORK   (Canada)

^w QUEEN S UNIVERSITY   (Canada)

more..

Author keywords

99th percentile; Acute coronary syndrome; Cutoffs; Healthy population; High sensitivity troponin; Myocardial infarction

Indexed keywords

TROPONIN T;

ACUTE CORONARY SYNDROME; BLOOD CHEMISTRY; CANADA; CLINICAL ASSESSMENT; EDITORIAL; EMERGENCY CARE; HEART INFARCTION; HUMAN; MEDICAL SOCIETY; PRACTICE GUIDELINE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

ACUTE CORONARY SYNDROME; ADULT; AGED; CANADA; CLINICAL CHEMISTRY TESTS; EMERGENCY MEDICAL SERVICES; FEMALE; GUIDELINES AS TOPIC; HUMANS; MALE; MEDICAL LABORATORY PERSONNEL; MIDDLE AGED; MYOCARDIAL INFARCTION; SENSITIVITY AND SPECIFICITY; TROPONIN; YOUNG ADULT;

EID: 80054072480     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2011.08.001     Document Type: Editorial

References (54)

1. Thygesen K., Alpert J.S., White H.D. Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. J Am Coll Cardiol 2007, 50:2173-2195.
2. Keller T., Zeller T., Peetz D., et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009, 361:868-877.
3. Reichlin T., Hochholzer W., Bassetti S., et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 2009, 361:858-867.
4. Mills N.L., Churchhouse A.M., Lee K.K., et al. Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome. JAMA 2011, 305:1210-1216.
5. Latini R., Masson S., Anand I.S., et al. Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure. Circulation 2007, 116:1242-1249.
6. Venge P., Johnston N., Lindahl B., James S. Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia. J Am Coll Cardiol 2009, 54:1165-1172.
7. Kavsak P.A., Wang X., Ko D.T., MacRae A.R., Jaffe A.S. Short- and long-term risk stratification using a next-generation, high-sensitivity research cardiac troponin I (hs-cTnI) assay in an emergency department chest pain population. Clin Chem 2009, 55:1809-1815.
8. Omland T., de Lemos J.A., Sabatine M.S., et al. A sensitive cardiac troponin T assay in stable coronary artery disease. N Engl J Med 2009, 361:2538-2547.
9. Januzzi J.L., Bamberg F., Lee H., et al. High-sensitivity troponin T concentrations in acute chest pain patients evaluated with cardiac computed tomography. Circulation 2010, 121:1227-1234.
10. deFilippi C.R., de Lemos J.A., Christenson R.H., et al. Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults. JAMA 2010, 304:2494-2502.
11. de Lemos J.A., Drazner M.H., Omland T., et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 2010, 304:2503-2512.
12. Saunders J.T., Nambi V., de Lemos J.A., et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the atherosclerosis risk in communities study. Circulation 2011, 123:1367-1376.
13. Kavsak P.A., Xu L., Yusuf S., McQueen M.J. High Sensitivity Cardiac troponin I Measurement for Risk Stratification in a Stable High Risk Population. Clin Chem 2011, 57:1146-1153.
14. Apple F.S. High-sensitivity cardiac troponin for screening large populations of healthy people: is there risk?. Clin Chem 2011, 57:537-539.
15. Morrow D.A., Cannon C.P., Jesse R.L., et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Clin Chem 2007, 53:552-574.
16. MacRae A.R., Kavsak P.A., Lustig V., et al. Assessing the requirement for the 6-hour interval between specimens in the American Heart Association Classification of Myocardial Infarction in Epidemiology and Clinical Research Studies. Clin Chem 2006, 52:812-818.
17. Thygesen K., Mair J., Katus H., et al. Recommendations for the use of cardiac troponin measurement in acute cardiac care. Eur Heart J 2010, 31:2197-2204.
18. Amsterdam E.A., Kirk J.D., Bluemke D.A., et al. Testing of low-risk patients presenting to the emergency department with chest pain: a scientific statement from the American Heart Association. Circulation 2010, 122:1756-1777.
19. Kavsak P., Jaffe A.S. Sensitive cardiac troponin assays. N Engl J Med 2009, 361:2575-2576.
20. Wu A., Collinson P., Jaffe A., Morrow D. High-sensitivity cardiac troponin assays: what analytical and clinical issues need to be addressed before introduction into clinical practice? Interview by Fred S. Apple. Clin Chem 2010, 56:886-891.
21. Apple F.S. A new season for cardiac troponin assays: it's time to keep a scorecard. Clin Chem 2009, 55:1303-1306.
22. de Lemos J.A., Morrow D.A. deFilippi CR. Highly sensitive troponin assays and the cardiology community: a love/hate relationship?. Clin Chem 2011, 57:826-829.
23. McGill D., Talaulikar G., Potter J.M., Koerbin G., Hickman P.E. Over time, high-sensitivity TnT replaces NT-proBNP as the most powerful predictor of death in patients with dialysis-dependent chronic renal failure. Clin Chim Acta 2010, 411:936-939.
24. Kavsak P.A. Troponin levels in hemodialysis patients: interpretation based on guidelines, changing concentrations and high-sensitivity assays. Nephrol Dial Transplant 2011, 26:1112-1113.
25. Kavsak P.A., Dhesy-Thind S. Cardiac troponin cutoffs: the importance of assay sensitivity and the patient population. J Clin Oncol 2011, 29(7):e177.
26. Chan M.K., Seiden-Long I., Aytekin M., et al. Canadian Laboratory Initiative on Pediatric Reference Interval Database (CALIPER): pediatric reference intervals for an integrated clinical chemistry and immunoassay analyzer, Abbott ARCHITECT ci8200. Clin Biochem 2009, 42:885-891.
27. Blasutig I.M., Jung B., Kulasingam V., et al. Analytical evaluation of the VITROS 5600 Integrated System in a pediatric setting and determination of pediatric reference intervals. Clin Biochem 2010, 43:1039-1044.
28. Weindling S.N., Wernovsky G., Colan S.D., et al. Myocardial perfusion, function and exercise tolerance after the arterial switch operation. J Am Coll Cardiol 1994, 23:424-433.
29. Elhendy A., Zoet-Nugteren S., Cornel J.H., et al. Functional assessment of ALCAPA syndrome by dobutamine stress thallium-201 SPECT and echocardiography. J Nucl Med 1996, 37:748-751.
30. Muta H., Ishii M. Percutaneous coronary intervention versus coronary artery bypass grafting for stenotic lesions after Kawasaki disease. J Pediatr 2010, 157:120-126.
31. Røsjø H., Andreassen J., Edvardsen T., Omland T. Prognostic usefulness of circulating high-sensitivity troponin T in aortic stenosis and relation to echocardiographic indexes of cardiac function and anatomy. Am J Cardiol 2011, 108:88-91.
32. Saenger A.K., Beyrau R., Braun S., et al. Multicentre analytical evaluation of a high-sensitivity troponin T assay. Clin Chim Acta 2011, 412:748-754.
33. Mingels A., Jacobs L., Michielsen E., Swaanenburg J., Wodzig W., van Dieijen-Visser M. Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays. Clin Chem 2009, 55:101-108.
34. Kavsak P.A., McQueen M.J. High sensitivity cardiac troponin concentration cutoffs-is a healthy population the right reference population for those with underlying cardiac disease?. Clin Biochem 2010, 43:1037-1038.
35. Kavsak P.A., Walsh M., Srinathan S., et al. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study. Clin Biochem 2011, 44:1021-1024.
36. Giannitsis E., Kurz K., Hallermayer K., Jarausch J., Jaffe A.S., Katus H.A. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem 2010, 56:254-261.
37. Huang Y., Dhesy-Thind S., Hirte H., Hotte S., Kavsak P. Establishing a reference interval for the high sensitive Troponin T assay in treatment-naïve cancer patients 2011, AACC, accepted abstract.
38. Hallén J., Johansen O.E., Birkeland K.I., et al. Determinants and prognostic implications of cardiac troponin T measured by a sensitive assay in type 2 diabetes mellitus. Cardiovasc Diabetol 2010, 9:52.
39. T. Troponin hs (high sensitive) package insert 2010-09, V1 Can English.
40. Dolci A., Braga F., Valente C., Guzzetti S., Panteghini M. Impact of implementation of the high-sensitivity cardiac troponin T assay in a university hospital setting. Clin Chem 2011, 57:1211-1212.
41. Reiter M., Twerenbold R., Reichlin T., et al. Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays. Eur Heart J 2011, 32:1379-1389.
42. Hochholzer W., Reichlin T., Twerenbold R., et al. Incremental value of high-sensitivity cardiac troponin T for risk prediction in patients with suspected acute myocardial infarction. Clin Chem 2011, 57:1318-1326.
43. Lindahl B., Venge P., James S. The new high-sensitivity cardiac troponin T assay improves risk assessment in acute coronary syndromes. Am Heart J 2010, 160:224-229.
44. Weber M., Bazzino O., Estrada J.L., et al. Improved diagnostic and prognostic performance of a new high-sensitivity troponin T assay in patients with acute coronary syndrome. Am Heart J 2011, 162:81-88.
45. Harvey W.D. Higher sensitivity troponin levels in the community: what do they mean and how will the diagnosis of myocardial infarction be made?. Am Heart J 2010, 159:933-936.
46. Vasile V.C., Saenger A.K., Kroning J.M., Jaffe A.S. Biological and analytical variability of a novel high-sensitivity cardiac troponin T assay. Clin Chem 2010, 56:1086-1090.
47. Frankenstein L., Wu A.H., Hallermayer K., Wians F.H., Giannitsis E., Katus H.A. Biological Variation and Reference Change Value of High-Sensitivity Troponin T in Healthy Individuals during Short and Intermediate Follow-up Periods. Clin Chem 2011, 57:1068-1071.
48. Giannitsis E., Becker M., Kurz K., Hess G., Zdunek D., Katus H.A. High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission. Clin Chem 2010, 56:642-650.
49. Reichlin T., Irfan A., Twerenbold R., et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation 2011, 124:136-145.
50. Apple F.S. Edging closer to early optimal patient management with high-sensitivity cardiac troponin assay. Circulation 2011, 124:127-129.
51. Aldous S.J., Richards A.M., Cullen L., Than M.P. Early dynamic change in high-sensitivity cardiac troponin T in the investigation of acute myocardial infarction. Clin Chem 2011 July 22, [Epub ahead of print].
52. Turer A.T., Addo T.A., Martin J.L., et al. Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay. J Am Coll Cardiol 2011, 57:2398-2405.
53. White H.D. Pathobiology of troponin elevations do elevations occur with myocardial ischemia as well as necrosis. J Am Coll Cardiol 2011, 57:2406-2408.
54. Kavsak P.A. Early standardization of high sensitivity troponin T reporting - a lost opportunity. Clin Biochem 2011, 44:758-759.