The relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 71, Issue 7, 2011, Pages 606-612

  Taslipinar, Abdullah ^a   Yaman, Halil ^a   Yilmaz, Mahmut Ilker ^a   Demirbas, Seref ^a   Saglam, Mutlu ^a   Taslipinar, Mine Yavuz ^b   Agilli, Mehmet ^a   Kurt, Yasemin Gulcan ^a   Sonmez, Alper ^a   Azal, Omer ^a   Bolu, Erol ^a   Yenicesu, Mujdat ^a   Kutlu, Mustafa ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

^b Etlik Training and Research Hospital   (Turkey)

Author keywords

Diabetic nephropathy; endothelial dysfunction; interleukin 6; tumor necrosis factor alpha

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIABETIC PATIENT; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; FEMALE; GLOMERULUS; HUMAN; IMMUNE SYSTEM; INFLAMMATION; LABORATORY TEST; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA;

BIOLOGICAL MARKERS; BLOOD VESSELS; C-REACTIVE PROTEIN; CAROTID INTIMA-MEDIA THICKNESS; DIABETES COMPLICATIONS; DIABETES MELLITUS; DIABETIC NEPHROPATHIES; ENDOTHELIUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INFLAMMATION; INTERLEUKIN-6; KIDNEY GLOMERULUS; MALE; MIDDLE AGED; PROTEINURIA; TUMOR NECROSIS FACTOR-ALPHA; VASODILATION;

EID: 80054060223     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365513.2011.598944     Document Type: Article

References (42)

1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projetions for 2030. Diabetes Care 2004;27:1047-53. (Pubitemid 38579764)
2. Mehta RS, Karki P, Sharma SK. Risk factors, associated health problems, reasons for admission and knowledge profi le of diabetes patients admitted in BPKIHS. Kathmandu Univ Med J (KUMJ) 2006;4:11-3. (Pubitemid 44383792)
3. Edgley AJ, Tare M, Evans RG, Skordilis C, Parkington HC. In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocininduced diabetes. Am J Physiol Regul Integr Comp Physiol 2008;295:R829 - 39.
4. Dogra G, Irish A, Chan D, Watts G. Insulin resistance, infl ammation, and blood pressure determine vascular dysfunction in CKD. Am J Kidney Dis 2006;48:926-34. (Pubitemid 44895366)
5. Rubio-Guerra AF, Vargas-Robles H, Medina-Santillá n R, Escalante-Acosta BA. Levels of soluble adhesion molecules among normal and hypertensive type 2 diabetic patients. Gac Med Mex 2008;144:11-4.
6. Jä r visalo MJ, Raitakari M, Toikka JO, Putto-Laurila A, Rontu R, Laine S, Lehtim ä ki T, R önnemaa T, Viikari J, Raitakari OT. Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes. Circulation 2004;109:1750-5. (Pubitemid 38500678)
7. Agha A, Amer W, Anwar E, Bashir K. Reduction of microalbuminuria by using losartan in normotensive patients with type 2 diabetes mellitus: A randomized controlled trial. Saudi J Kidney Dis Transpl 2009;20:429-35.
8. Molitch ME, DeFronzo RA, Franz MJ, Keane WF, Mogensen CE, Parving HH, Steffes MW; American Diabetes Association. Nephropathy in diabetes. Diabetes Care 2004;27: S79 - 83.
9. Karnib HH, Ziyadeh FN. The cardiorenal syndrome in diabetes mellitus. Diabetes Res Clin Pract 2010;89:201-8.
10. Yilmaz MI, Saglam M, Qureshi AR, Carrero JJ, Caglar K, Eyileten T, Sonmez A, Cakir E, Oguz Y, Vural A, Yenicesu M, Stenvinkel P, Lindholm B, Axelsson J. Endothelial dysfunction in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin. Nephrol Dial Transplant 2008;23:1621-7. (Pubitemid 351767738)
11. Warram JH, Laffel LM, Ganda OP, Christlieb AR. Coronary artery disease is the major determinant of excess mortality in patients with insulin-dependent diabetes mellitus and persistent proteinuria. J Am Soc Nephrol 1992;3:S104 - 10.
12. Suliman ME, Yilmaz MI, Carrero JJ, Qureshi AR, Saglam M, Ipcioglu OM, Yenicesu M, Tong M, Heimb ürger O, Barany P, Alvestrand A, Lindholm B, Stenvinkel P. Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease. Clin J Am Soc Nephrol 2008;3:976-85.
13. H ansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 2006;6: 508-19. (Pubitemid 43980523)
14. Kleemann R, Zadelaar S, Kooistra T. Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardiovasc Res 2008;79:360-76.
15. Navarro JF, Mora C. Role of infl ammation in diabetic complications. Nephrol Dial Transplant 2005;20:2601-4. (Pubitemid 41672253)
16. Hak AE, Pols HA, Stehouwer CD, Meijer J, Kiliaan AJ, Hofman A, Breteler MM, Witteman JC. Markers of infl ammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study. J Clin Endocrinol Metab 2001;86:4398-405. (Pubitemid 32848565)
17. Chan WB, Chan NN, Lai CW, So WY, Lo MK, Lee KF, Chow CC, Metreweli C, Chan JC. Vascular defect beyond the endothelium in type II diabetic patients with overt nephropathy and moderate renal insuffi ciency. Kidney Int 2006;70:711-6. (Pubitemid 44215346)
18. Rivero A, Mora C, Muros M, Garcí a J, Herrera H, Navarro-Gonz á lez JF. Pathogenic perspectives for the role of infl ammation in diabetic nephropathy. Clin Sci (Lond) 2009;116:479-92.
19. Mastej K, Adamiec R. Neutrophil surface expression of CD11b and CD62L in diabetic microangiopathy. Acta Diabetol 2008;45:183-90.
20. Schram MT, Chaturvedi N, Schalkwijk C, Giorgino F, Ebeling P, Fuller JH, Stehouwer CD. Vascular risk factors and markers of endothelial function as determinants of infl ammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care 2003;26: 2165-73. (Pubitemid 41184269)
21. Schiffl H, Lang SM, Stratakis D, Fischer R. Effects of ultrapure dialysis fl uid on nutritional status and infl amatory parameters. Nephrol Dial Transplant 2001;16:1863 - 9.
22. Stenvinkel P, Heimb ürger O, Paultre F, Diczfalusy U, Wang T, Berglund L, Jogestrand T. Strong association between malnutrition, infl ammation, and atherosclerosis in chronic renal failure. Kidney Int 1999;55:1899 - 911. (Pubitemid 29197978)
23. Schram MT, Chaturvedi N, Schalkwijk C, Giorgino F, Ebeling P, Fuller JH, Stehouwer CD. Vascular risk factors and markers of endothelial function as determinants of infl ammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care 2003;26: 2165-73. (Pubitemid 41184269)
24. Wong CK, Ho AW, Tong PC, Yeung CY, Kong AP, Lun SW, Chan JC, Lam CW. Aberrant activation profi le of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy. Clin Exp Immunol 2007;149: 123-31. (Pubitemid 46897099)
25. Lu J, Randell E, Han Y, Adeli K, Krahn J, Meng QH. Increased plasma methylglyoxal level, infl ammation, and vascular endothelial dysfunction in diabetic nephropathy. Clin Biochem 2011;44:307-11.
26. N guyen D, Ping F, Mu W, Hill P, Atkins RC, Chadban SJ. Macrophage accumulation in human progressive diabetic nephropathy. Nephrology (Carlton) 2006;11:26-31.
27. Takebayashi K, Matsumoto S, Aso Y, Inukai T. Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients. J Diabetes Complicat 2006;20:98-104.
28. Clausen P, Jacobsen P, Rossing K, Jensen JS, Parving HH, Feldt-Rasmussen B. Plasma concentrations of VCAM-1 and ICAM-1 are elevated in patients with Type 1 diabetes mellitus with microalbuminuria and overt nephropathy. Diabet Med 2000;17:644-9.
29. Hirata K, Shikata K, Matsuda M, Akiyama K, Sugimoto H, Kushiro M, Makino H. Increased expression of selectins in kidneys of patients with diabetic nephropathy. Diabetologia 1998;41:185-92. (Pubitemid 28088395)
30. Sugimoto H, Shikata K, Hirata K, Akiyama K, Matsuda M, Kushiro M, Shikata Y, Miyatake N, Miyasaka M, Makino H. Increased expression of intercellular adhesion molecule-1 (ICAM-1) in diabetic rat glomeruli: glomerular hyperfi ltration is a potential mechanism of ICAM-1 upregulation. Diabetes 1997;46:2075-81. (Pubitemid 27512099)
31. Albertini JP, Valensi P, Lormeau B, Aurousseau MH, Ferri è re F, Attali JR, Gattegno L. Elevated concentrations of soluble E-selectin and vascular cell adhesion molecule-1 in NIDDM. Effect of intensive insulin treatment. Diabetes Care 1998;21:1008-13. (Pubitemid 28488797)
32. Zhang L, Zhao F, Yang Y, Qi L, Zhang B, Wang F, Wang S, Liu L, Wang H. Association between carotid artery intimamedia thickness and early-stage CKD in a Chinese population. Am J Kidney Dis 2007;49:786-92. (Pubitemid 46802933)
33. Ito H, Komatsu Y, Mifune M, Antoku S, Ishida H, Takeuchi Y, Togane M. The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a crosssectional study. Cardiovasc Diabetol 2010;9:18.
34. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C. Infl ammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int 1999;55: 648-58. (Pubitemid 29082891)
35. Stenvinkel P, Heimb ürger O, Paultre F, Diczfalusy U, Wang T, Berglund L, Jogestrand T. Strong association between malnutrition, infl ammation, and atherosclerosis in chronic renal failure. Kidney Int 1999;55:1899 - 911. (Pubitemid 29197978)
36. Naidoo DP. The link between microalbuminuria, endothelial dysfunction and cardiovascular disease in diabetes. Cardiovasc J S Afr 2002;13:194-9.
37. Mezzano D, Pais EO, Aranda E, Panes O, Downey P, Ortiz M, Tagle R, Gonz á lez F, Quiroga T, Caceres MS, Leighton F, Pereira J. Infl ammation, not hyperhomocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia. Kidney Int 2001;60: 1844-50. (Pubitemid 32999989)
38. Navarro JF, Mora C, Gó m ez M, Muros M, Ló p ez-Aguilar C, Garc í a J. Infl uence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor-alpha and interleukin-6 in type 2 diabetic patients. Nephrol Dial Transplant 2008;23:919-26. (Pubitemid 351767554)
39. Sahakyan K, Klein BE, Lee KE, Tsai MY, Klein R. Infl ammatory and endothelial dysfunction markers and proteinuria in persons with type 1 diabetes mellitus. Eur J Endocrinol 2010;162:1101-5.
40. Pecoits-Filho R, Heimbürger O, Bá r án y P, Suliman M, Fehrman-Ekholm I, Lindholm B, Stenvinkel P. Associations between circulating infl ammatory markers and residual renal function in CRF patients. Am J Kidney Dis 2003;41: 1212-8. (Pubitemid 36637976)
41. Stam F, van Guldener C, Becker A, Dekker JM, Heine RJ, Bouter LM, Stehouwer CD. Endothelial dysfunction contributes to renal function-associated cardiovascular mortality in a population with mild renal insuffi ciency: the Hoorn study. J Am Soc Nephrol 2006;17:537-45.
42. Nelson CL, Karschimkus CS, Dragicevic G, Packham DK, Wilson AM, O'Neal D, Becker GJ, Best JD, Jenkins AJ. Systemic and vascular infl ammation is elevated in early IgA and type 1 diabetic nephropathies and relates to vascular disease risk factors and renal function. Nephrol Dial Transplant 2005;20:2420-6. (Pubitemid 41548866)