Mixed medullary-follicular carcinoma of the thyroid: Diagnostic dilemmas in fine-needle aspiration cytology

Diagnostic Cytopathology

Volumn 39, Issue 11, 2011, Pages 862-865

  Hanna, Atef N ^a   Michael, Claire W ^a   Jing, Xin ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

fine needle aspiration cytology; mixed medullary follicular carcinoma; thyroid

Indexed keywords

CALCITONIN; CARCINOEMBRYONIC ANTIGEN; CHROMOGRANIN; PROTEIN RET; THYROGLOBULIN;

ADULT; ARTICLE; ASPIRATION CYTOLOGY; CALCITONIN BLOOD LEVEL; CANCER CELL; CANCER CYTODIAGNOSIS; CANCER GROWTH; CANCER SIZE; CANCER SURGERY; CASE REPORT; CELL NUCLEUS; CELL STRUCTURE; CHROMATIN; CYTOPLASM; DIFFERENTIAL DIAGNOSIS; ECHOGRAPHY; EXON; FAMILY HISTORY; FEMALE; FOLLOW UP; GENE MUTATION; HASHIMOTO DISEASE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LYMPH NODE DISSECTION; MICROSCOPY; MIXED THYROID MEDULLARY FOLLICULAR CARCINOMA; MIXED TUMOR; MUTATIONAL ANALYSIS; ONCOCYTOMA; PRIORITY JOURNAL; REPEAT PROCEDURE; THYROID FOLLICULAR CARCINOMA; THYROID MEDULLARY CARCINOMA; THYROID NODULE; THYROIDECTOMY;

BIOPSY, FINE-NEEDLE; BRAIN STEM NEOPLASMS; CARCINOMA, MEDULLARY; CYTODIAGNOSIS; FEMALE; HUMANS; MIDDLE AGED; MIXED TUMOR, MALIGNANT; THYROID GLAND; THYROID NEOPLASMS;

EID: 80054054861     PISSN: 87551039     EISSN: 10970339     Source Type: Journal    
DOI: 10.1002/dc.21560     Document Type: Article

References (18)

1. DeLellis RA,; International Agency for Research on Cancer; World Health Organization; International Academy of Pathology. Pathology and genetics of tumours of endocrine organs. Lyon: IARC Press; 2004. 320 p.
2. Volante M, Papotti M, Roth J, et al. Mixed medullary-follicular thyroid carcinoma. Molecular evidence for a dual origin of tumor components. Am J Pathol 1999; 155: 1499-1509.
3. Orlandi F, Chiefari E, Caraci P, et al. RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma. J Endocrinol Invest 2001; 24: 51-55. (Pubitemid 32166330)
4. Frank-Raue K, Dohring J, Scheumann G, et al. New mutations in the RET protooncogene-L881V-associated with medullary thyroid carcinoma and -R770Q- in a patient with mixed medullar/follicular thyroid tumour. Exp Clin Endocrinol Diabetes 2009.
5. Kini SR, Miller JM, Hamburger JI, Smith MJ,. Cytopathologic features of medullary carcinoma of the thyroid. Arch Pathol Lab Med 1984; 108: 156-159. (Pubitemid 14181719)
6. Forrest CH, Frost FA, de Boer WB, Spagnolo DV, Whitaker D, Sterrett BF,. Medullary carcinoma of the thyroid: Accuracy of diagnosis of fine-needle aspiration cytology. Cancer 1998; 84: 295-302. (Pubitemid 28516867)
7. Collins BT, Cramer HM, Tabatowski K, Hearn S, Raminhos A, Lampe H,. Fine needle aspiration of medullary carcinoma of the thyroid. Cytomorphology, immunocytochemistry and electron microscopy. Acta Cytol 1995; 39: 920-930.
8. Kini SR,. Thyroid cytopathology: An atlas and text. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008. p 276-286.
9. Filie AC, Asa SL, Geisinger KR, et al. Utilization of ancillary studies in thyroid fine needle aspirates: A synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference. Diagn Cytopathol 2008; 36: 438-441. (Pubitemid 351829801)
10. Duskova J, Janotova D, Svobodova E, Novak Z, Tretinik P,. Fine needle aspiration biopsy of mixed medullary-follicular thyroid carcinoma. A report of two cases. Acta Cytol 2003; 47: 71-77. (Pubitemid 36172939)
11. Hsieh MH, Lin MC, Shun CT, Chang TC,. Fine needle aspiration cytology of mixed medullary-follicular thyroid carcinoma: A case report. Acta Cytol 2008; 52: 361-365.
12. Luboshitzky R, Dharan M,. Mixed follicular-medullary thyroid carcinoma: A case report. Diagn Cytopathol 2004; 30: 122-124. (Pubitemid 38160651)
13. Maruna P, Duskova J, Limanova Z, Dvorakova S, Vaclavikova E, Bendlova B,. Mixed medullary and follicular cell carcinoma of the thyroid in a 71-year-old man with history of malignant melanoma. Med Sci Monit 2008; 14: CS31-CS36. (Pubitemid 351520829)
14. Michael CW, Zhu W,. How important is on-site adequacy assessment for thyroid FNA? An evaluation of 883 cases. Diagn Cytopathol 2007; 35: 183-186. (Pubitemid 46355354)
15. Cakir M, Altunbas H, Balci MK, Karayalcin U, Karpuzoglu G,. Medullary thyroid carcinoma, follicular variant. Endocr Pathol 2002; 13: 75-79. (Pubitemid 34665118)
16. Giove E, Renzulli G, Lorusso C, Merlicco D, Iacobone D,. Mixed medullary and follicular carcinoma of the thyroid: Report of one case. Ann Ital Chir 2004; 75: 251-256; discussion 257.
17. Mizukami Y, Nonomura A, Michigishi T, Noguchi M, Ishizaki T,. Mixed medullary-follicular carcinoma of the thyroid gland: A clinicopathologic variant of medullary thyroid carcinoma. Mod Pathol 1996; 9: 631-635. (Pubitemid 26227563)
18. Nangue C, Bron L, Portmann L, et al. Mixed medullary-papillary carcinoma of the thyroid: Report of a case and review of the literature. Head Neck 2009; 31: 968-974.