RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma

Journal of Endocrinological Investigation

Volumn 24, Issue 1, 2001, Pages 51-55

  Orlandi, F ^a   Chiefari, E ^b   Caraci, P ^a   Mussa, A ^a   Gonzatto, I ^a   De Giuli, P ^c   Giuffrida, D ^c   Angeli, A ^a   Filetti, S ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c SAN LUIGI GONZAGA HOSPITAL   (Italy)

Author keywords

Mixed thyroid carcinoma; RET oncogene; Thyroid neoplasm

Indexed keywords

CALCITONIN; CARCINOEMBRYONIC ANTIGEN; ELSA-HCT;

AGED; ARTICLE; ASSAY; CANCER TISSUE; CASE REPORT; FEMALE; FOLLOW UP; GENE ACTIVATION; GENE MUTATION; GENETIC ANALYSIS; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE DISSECTION; ONCOGENE RET; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTO ONCOGENE; RESTRICTION MAPPING; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION; THYROID FOLLICULAR CARCINOMA; THYROID MEDULLARY CARCINOMA; THYROIDECTOMY; TREATMENT OUTCOME;

ADENOCARCINOMA, FOLLICULAR; AGED; CARCINOMA, MEDULLARY; DROSOPHILA PROTEINS; FEMALE; HETEROZYGOTE; HUMANS; IMMUNOHISTOCHEMISTRY; MUTATION; NEOPLASMS, MULTIPLE PRIMARY; POINT MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; THYROID NEOPLASMS;

EID: 0035114386     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03343809     Document Type: Article

References (21)

1. Tumors of the thyroid gland
2. Current diagnosis and management of medullary thyroid carcinoma
3. Relevance of RET proto-oncogene mutations in sporadic medullary thyroid carcinoma
4. Molecular mechanisms of RET activation in human neoplasia
5. The relationship between specific RET Proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2: International RET mutation consortium analysis
6. Mixed medullary-follicular carcinoma of the thyroid. A morphological, immunohistochemical and in situ hybridization analysis of 11 cases
7. Carcinoma of the thyroid with a medullary and follicular pattern: Morphologic, immunohistochemical, and clinical laboratory studies
8. Mixed medullary and follicular carcinoma of the thyroid
9. Histological typing of thyroid tumours
10. The ultimobranchial gland and congenital thyroid abnormalities in man
11. Experimental carcinogenesis in the thyroid follicular and C cells. A comparison of the effect of variation in dietary calcium and of radiation
12. Coexistence of papillary and medullary carcinoma of the thyroid gland-mixed or collision tumour? Clinico-pathological analysis of three cases
13. Concurrent medullary and papillary carcinomas of thyroid with lymph node metastases. A collision phenomenon
14. Cloning and expression of the RET proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains
15. Analysis of RET proto-oncogene abnormalities in patients with MEN 2A, MEN 2B, familial or sporadic medullary thyroid carcinoma
16. Mixed medullary-follicular thyroid carcinoma. Molecular evidence for a dual origin of tumor components
17. Analysis of RET proto-oncogene point mutations distinguishes heritable from nonheritable medullary carcinomas
18. Somatic mutations of the RET proto-oncogene in sporadic medullary thyroid carcinoma are not restricted to exon 16 and are associated with tumor recurrence
19. Concurrent production of calcitonin and thyroglobulin by the same neoplastic cells
20. Study of calcitonin and thyroglobulin gene expression in human mixed follicular and medullary thyroid carcinoma
21. Medullary carcinoma of the thyroid gland. Clinical, pathological, and immunohistochemical features with review of the literature