VP8* antigen produced in tobacco transplastomic plants confers protection against bovine rotavirus infection in a suckling mouse model

Journal of Biotechnology

Volumn 156, Issue 2, 2011, Pages 100-107

  Lentz, E M ^a   Mozgovoj, M V ^b   Bellido, D ^b   Santos, M J Dus ^b   Wigdorovitz, A ^b   Bravo Almonacid, F F ^a,c  

^a INSTITUTO DE INVESTIGACIONES EN INGENIERÍA GENÉTICA Y BIOLOGÍA MOLECULAR   (Argentina)

^b INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA INTA   (Argentina)

^c UNIVERSIDAD NACIONAL DE QUILMES   (Argentina)

Author keywords

Bovine rotavirus; Challenge; Tobacco; Transplastomic plants; Vaccine; VP8*

Indexed keywords

ARGENTINA; C-TERMINAL FRAGMENTS; CAPSID PROTEINS; CHALLENGE; FRESH TISSUES; IMMUNE RESPONSE; MAMMALIAN SPECIES; MOUSE MODELS; N-TERMINALS; NORTHERN BLOTS; PROTEOLYTIC CLEAVAGE; RECOMBINANT PROTEIN; ROTAVIRUSES; SOUTHERN BLOT; SUBUNIT VACCINE; TRANSPLASTOMIC PLANTS; VIRAL INFECTIVITY; VIRUS NEUTRALIZATION; WESTERN BLOTS;

ANTIGENS; CARBOXYLIC ACIDS; MAMMALS; PLANT EXTRACTS; PROTEINS; TISSUE; VIRUSES;

TOBACCO;

DNA FRAGMENT; MESSENGER RNA; NICOTINE; UNCLASSIFIED DRUG; VIRUS PROTEIN; VP8 PROTEIN; CAPSID PROTEIN; RECOMBINANT PROTEIN; ROTAVIRUS VACCINE; SUBUNIT VACCINE; VP4 PROTEIN, ROTAVIRUS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CHLOROPLAST; CONTROLLED STUDY; FEASIBILITY STUDY; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STABILITY; RNA EXTRACTION; ROTAVIRUS INFECTION; TOBACCO; ANIMAL; CATTLE; GENETICS; IMMUNOLOGY; PROTEIN TERTIARY STRUCTURE; ROTAVIRUS; SUCKLING; VACCINATION;

BOVINE ROTAVIRUS; BREDA VIRUS; MAMMALIA; MIRIDAE; MUS; NICOTIANA TABACUM; ROTAVIRUS; ROTAVIRUS A;

ANIMALS; ANIMALS, SUCKLING; CAPSID PROTEINS; CATTLE; FEMALE; MICE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; ROTAVIRUS; ROTAVIRUS INFECTIONS; ROTAVIRUS VACCINES; TOBACCO; VACCINATION; VACCINES, SUBUNIT;

EID: 80054043127     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2011.08.023     Document Type: Article

References (50)

1. Alvarez M.L., Topal E., Martin F., Cardineau G.A. Higher accumulation of F1-V fusion recombinant protein in plants after induction of protein body formation. Plant Molecular Biology 2010, 72:75-89.
2. Arlen P.A., Singleton M., Adamovicz J.J., Ding Y., Davoodi-Semiromi A., Daniell H. Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts. Infection and Immunity 2008, 76:3640-3650.
3. Bellido D., Craig P.O., Mozgovoj M.V., Gonzalez D.D., Wigdorovitz A., Goldbaum F.A., Dus Santos M.J. Brucella spp. lumazine synthase as a bovine rotavirus antigen delivery system. Vaccine 2009, 27:136-145.
4. Birch-Machin I., Newell C.A., Hibberd J.M., Gray J.C. Accumulation of rotavirus VP6 protein in chloroplasts of transplastomic tobacco is limited by protein stability. Plant Biotechnology Journal 2004, 2:261-270.
5. Bock R., Warzecha H. Solar-powered factories for new vaccines and antibiotics. Trends Biotechnology 2010, 28:246-252.
6. Boehm R. Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms. Annals of the New York Academy of Sciences 2007, 1102:121-134.
7. Clark S.M., Roth J.R., Clark M.L., Barnett B.B., Spendlove R.S. Trypsin enhancement of rotavirus infectivity: mechanism of enhancement. Journal of Virology 1981, 39:816-822.
8. Crawford S.E., Labbe M., Cohen J., Burroughs M.H., Zhou Y.J., Estes M.K. Characterization of virus-like particles produced by the expression of rotavirus capsid proteins in insect cells. Journal of Virology 1994, 68:5945-5952.
9. Daniell H., Chebolu S., Kumar S., Singleton M., Falconer R. Chloroplast-derived vaccine antigens and other therapeutic proteins. Vaccine 2005, 23:1779-1783.
10. Daniell H., Singh N.D., Mason H., Streatfield S.J. Plant-made vaccine antigens and biopharmaceuticals. Trends Plant Science 2009, 14:669-679.
11. Davoodi-Semiromi A., Schreiber M., Nalapalli S., Verma D., Singh N.D., Banks R.K., Chakrabarti D., Daniell H. Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery. Plant Biotechnology Journal 2010, 8:223-242.
12. De Cosa B., Moar W., Lee S.B., Miller M., Daniell H. Overexpression of the Bt cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals. Nature Biotechnology 2001, 19:71-74.
13. * core. Journal of Virology 2001, 75:7339-7350.
14. Dus Santos M.J., Wigdorovitz A., Trono K., Rios R.D., Franzone P.M., Gil F., Moreno J., Carrillo C., Escribano J.M., Borca M.V. A novel methodology to develop a foot and mouth disease virus (FMDV) peptide-based vaccine in transgenic plants. Vaccine 2002, 20:1141-1147.
15. Estes M.K., Kang G., Zeng C.Q., Crawford S.E., Ciarlet M. Pathogenesis of rotavirus gastroenteritis. Novartis Foundation Symposium 2001, 238:82-96. (discussion 96-100).
16. Fagard M., Vaucheret H. (Trans)Gene silencing in plants: how many mechanisms?. Annual Review of Plant Physiology and Plant Molecular Biology 2000, 51:167-194.
17. *, in Escherichia coli. Protein Expression and Purification 2006, 46:196-203.
18. Fernandez-San Millan A., Mingo-Castel A., Miller M., Daniell H. A chloroplast transgenic approach to hyper-express and purify human serum albumin, a protein highly susceptible to proteolytic degradation. Plant Biotechnology Journal 2003, 1:71-79.
19. Fernandez F.M., Conner M.E., Hodgins D.C., Parwani A.V., Nielsen P.R., Crawford S.E., Estes M.K., Saif L.J. Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines. Vaccine 1998, 16:507-516.
20. Garaicoechea L., Bok K., Jones L.R., Combessies G., Odeon A., Fernandez F., Parreno V. Molecular characterization of bovine rotavirus circulating in beef and dairy herds in Argentina during a 10-year period (1994-2003). Veterinary Microbiology 2006, 118:1-11.
21. * subunit of the VP4 capsid protein. Viral Immunology 2000, 13:187-200.
22. Gleba Y., Klimyuk V., Marillonnet S. Viral vectors for the expression of proteins in plants. Current Opinion in Biotechnology 2007, 18:134-141.
23. Glenz K., Bouchon B., Stehle T., Wallich R., Simon M.M., Warzecha H. Production of a recombinant bacterial lipoprotein in higher plant chloroplasts. Nature Biotechnology 2006, 24:76-77.
24. Hager M., Biehler K., Illerhaus J., Ruf S., Bock R. Targeted inactivation of the smallest plastid genome-encoded open reading frame reveals a novel and essential subunit of the cytochrome b(6)f complex. EMBO Journal 1999, 18:5834-5842.
25. Ijaz M.K., Sabara M.I., Frenchick P.J., Babiuk L.A. Effect of different routes of immunization with bovine rotavirus on lactogenic antibody response in mice. Antiviral Research 1987, 8:283-297.
26. Kalica A.R., Flores J., Greenberg H.B. Identification of the rotaviral gene that codes for hemagglutination and protease-enhanced plaque formation. Virology 1983, 125:194-205.
27. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
28. Lee J., Yoo D., Redmond M.J., Attah-Poku S.K., van den Hurk J.V., Babiuk L.A. Characterization of the interaction between VP8 of bovine rotavirus C486 and cellular components on MA-104 cells and erythrocytes. Canadian Journal of Veterinary Research 1998, 62:56-62.
29. Lentz E.M., Segretin M.E., Morgenfeld M.M., Wirth S.A., Dus Santos M.J., Mozgovoj M.V., Wigdorovitz A., Bravo-Almonacid F.F. High expression level of a foot and mouth disease virus epitope in tobacco transplastomic plants. Planta 2010, 231:387-395.
30. Mackow E.R., Vo P.T., Broome R., Bass D., Greenberg H.B. Immunization with baculovirus-expressed VP4 protein passively protects against simian and murine rotavirus challenge. Journal of Virology 1990, 64:1698-1703.
31. Mason H.S., Lam D.M., Arntzen C.J. Expression of hepatitis B surface antigen in transgenic plants. Proceedings of the National Academy of Sciences of the United States of America 1992, 89:11745-11749.
32. McCabe M.S., Klaas M., Gonzalez-Rabade N., Poage M., Badillo-Corona J.A., Zhou F., Karcher D., Bock R., Gray J.C., Dix P.J. Plastid transformation of high-biomass tobacco variety Maryland Mammoth for production of human immunodeficiency virus type 1 (HIV-1) p24 antigen. Plant Biotechnology Journal 2008, 6:914-929.
33. Molina A., Hervas-Stubbs S., Daniell H., Mingo-Castel A.M., Veramendi J. High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. Plant Biotechnology Journal 2004, 2:141-153.
34. Oey M., Lohse M., Kreikemeyer B., Bock R. Exhaustion of the chloroplast protein synthesis capacity by massive expression of a highly stable protein antibiotic. Plant Journal 2009, 57:436-445.
35. Offit P.A., Clark H.F. Protection against rotavirus-induced gastroenteritis in a murine model by passively acquired gastrointestinal but not circulating antibodies. Journal of Virology 1985, 54:58-64.
36. * produced in plants using a TMV-based vector. Archives of Virology 2004, 149:2337-2348.
37. Peternel S., Grdadolnik J., Gaberc-Porekar V., Komel R. Engineering inclusion bodies for non denaturing extraction of functional proteins. Microbial Cell Factories 2008, 7:34-43.
38. Rosales-Mendoza S., Alpuche-Solis A.G., Soria-Guerra R.E., Moreno-Fierros L., Martinez-Gonzalez L., Herrera-Diaz A., Korban S.S. Expression of an Escherichia coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional oligomer in transplastomic tobacco plants. Plant Journal 2009, 57:45-54.
39. Ruf S., Biehler K., Bock R. A small chloroplast-encoded protein as a novel architectural component of the light-harvesting antenna. Journal of Cell Biology 2000, 149:369-378.
40. Ruggeri F.M., Greenberg H.B. Antibodies to the trypsin cleavage peptide VP8 neutralize rotavirus by inhibiting binding of virions to target cells in culture. Journal of Virology 1991, 65:2211-2219.
41. Saif L.J., Fernandez F.M. Group A rotavirus veterinary vaccines. The Journal of Infectious Diseases 1996, 174(Suppl. 1):S98-S106.
42. Scotti N., Alagna F., Ferraiolo E., Formisano G., Sannino L., Buonaguro L., De Stradis A., Vitale A., Monti L., Grillo S., Buonaguro F.M., Cardi T. High-level expression of the HIV-1 Pr55gag polyprotein in transgenic tobacco chloroplasts. Planta 2009, 229:1109-1122.
43. Shi Q., Li C., Zhang F. Nicotine synthesis in Nicotiana tabacum L. induced by mechanical wounding is regulated by auxin. Journal of Experimental Botany 2006, 57:2899-2907.
44. Streatfield S.J. Approaches to achieve high-level heterologous protein production in plants. Plant Biotechnology Journal 2007, 5:2-15.
45. Tiwari S., Verma P.C., Singh P.K., Tuli R. Plants as bioreactors for the production of vaccine antigens. Biotechnology Advances 2009, 27:449-467.
46. To T.L., Ward L.A., Yuan L., Saif L.J. Serum and intestinal isotype antibody responses and correlates of protective immunity to human rotavirus in a gnotobiotic pig model of disease. The Journal of General Virology 1998, 79:2661-2672.
47. Willits C.O., Swaim M.L., Connelly J.A., Brice B.A. Spectrophotometric determination of nicotine. Analytical Chemistry 1950, 430-433.
48. Wirth S., Segretin M.E., Mentaberry A., Bravo-Almonacid F. Accumulation of hEGF and hEGF-fusion proteins in chloroplast-transformed tobacco plants is higher in the dark than in the light. Journal of Biotechnology 2006, 125:159-172.
49. Zarate S., Espinosa R., Romero P., Mendez E., Arias C.F., Lopez S. The VP5 domain of VP4 can mediate attachment of rotaviruses to cells. Journal of Virology 2000, 74:593-599.
50. Zhou F., Badillo-Corona J.A., Karcher D., Gonzalez-Rabade N., Piepenburg K., Borchers A.M., Maloney A.P., Kavanagh T.A., Gray J.C., Bock R. High-level expression of human immunodeficiency virus antigens from the tobacco and tomato plastid genomes. Plant Biotechnology Journal 2008, 6:897-913.