-
2
-
-
0004284003
-
-
Marcel Dekker, Inc., New York, USA
-
H. G. Brittain, Polymorphism in Pharmaceutical Solids, Marcel Dekker, Inc., New York, USA, 1999
-
(1999)
Polymorphism in Pharmaceutical Solids
-
-
Brittain, H.G.1
-
3
-
-
77952225319
-
-
in, ed. R. Hilfiker, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 211-234
-
U. J. Griesser, in Polymorphism in the Pharmaceutical Industry, ed., R. Hilfiker, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2006, pp. 211-234
-
(2006)
Polymorphism in the Pharmaceutical Industry
-
-
Griesser, U.J.1
-
4
-
-
5044235632
-
Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?
-
DOI 10.1039/b402150a
-
O. Almarsson M. J. Zaworotko Chem. Commun. 2004 1889 1896 10.1039/b402150a (Pubitemid 39335992)
-
(2004)
Chemical Communications
, Issue.17
, pp. 1889-1896
-
-
Almarsson, O.1
Zaworotko, M.J.2
-
9
-
-
25844449757
-
Building co-crystals with molecular sense and supramolecular sensibility
-
DOI 10.1039/b505883j, 72
-
C. B. Aakeröy D. J. Salmon CrystEngComm 2005 7 439 448 10.1039/b505883j (Pubitemid 41396867)
-
(2005)
CrystEngComm
, vol.7
, pp. 439-448
-
-
Aakeroy, C.B.1
Salmon, D.J.2
-
10
-
-
36148966165
-
-
10.1107/S0108767398008551
-
G. R. Desiraju Angew. Chem., Int. Ed. 2007 46 8342 8356 10.1107/S0108767398008551
-
(2007)
Angew. Chem., Int. Ed.
, vol.46
, pp. 8342-8356
-
-
Desiraju, G.R.1
-
17
-
-
84860266180
-
-
Pat., WO/2008/096005
-
R. Israels, H. E. Saxell, M. Bratz, M. Kuhns and P. Erk, Pat., WO/2008/096005, 08. 02. 2008
-
(2008)
-
-
Israels, R.1
Saxell, H.E.2
Bratz, M.3
Kuhns, M.4
Erk, P.5
-
19
-
-
84889742010
-
-
PANalytical B.V., 2006, 2.2b
-
PANalytical B.V., 2006, 2.2b
-
-
-
-
22
-
-
33744498094
-
Mercury: Visualization and analysis of crystal structures
-
DOI 10.1107/S002188980600731X
-
C. F. Macrae P. R. Edgington P. McCabe E. Pidcock G. P. Shields R. Taylor M. Towler J. van de Streek J. Appl. Crystallogr. 2006 39 453 457 10.1107/S002188980600731X (Pubitemid 43806296)
-
(2006)
Journal of Applied Crystallography
, vol.39
, Issue.3
, pp. 453-457
-
-
Macrae, C.F.1
Edgington, P.R.2
McCabe, P.3
Pidcock, E.4
Shields, G.P.5
Taylor, R.6
Towler, M.7
Van De Streek, J.8
-
28
-
-
34047149355
-
-
The packing coefficient describes the tightness of the packing of molecules in a crystal, with a bigger value meaning tighter packing, and is calculated with the formula C(k) = Z*V(mol)/V(cell), where Z is the number of molecules in the unit cell, V(mol) is the molecular volume of the molecules and V(cell) is the volume of the unit cell. For these calculations the disorder of the solvent was not taken into consideration
-
K. M. Anderson J. W. Steed CrystEngComm 2007 9 328 330
-
(2007)
CrystEngComm
, vol.9
, pp. 328-330
-
-
Anderson, K.M.1
Steed, J.W.2
-
29
-
-
0242491567
-
-
4, where is the angle between the donor, hydrogen and acceptor and C and D are empirical parameters. Accurate determination of the hydrogen bond energy is, however, problematic for several reasons of which one is the power of 10 in the attractive term which makes the function sensitive for the separation of the hydrogen and acceptor atom as the energy drops rapidly with the increasing distance. The function is also sensitive for the bonding angle due to the power of 4 in the cosine term
-
S. Brodersen S. Wilke F. J. J. Leusen G. Engel Phys. Chem. Chem. Phys. 2003 5 4923 4931
-
(2003)
Phys. Chem. Chem. Phys.
, vol.5
, pp. 4923-4931
-
-
Brodersen, S.1
Wilke, S.2
Leusen, F.J.J.3
Engel, G.4
|