Inflammation-inducing Th1 and Th17 cells differ in their expression patterns of apoptosis-related molecules

Cellular Immunology

Volumn 271, Issue 2, 2011, Pages 210-213

  Tan, Cuiyan ^a   Ramaswamy, Madhu ^b   Shi, Guangpu ^a   Vistica, Barbara P ^a   Siegel, Richard M ^b   Gery, Igal ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

Activation induced cell death; Apoptosis; Apoptosis related molecules; Eye; Inflammation; Th1; Th17

Indexed keywords

CD3 ANTIBODY; FAS ANTIGEN; FAS LIGAND; LYMPHOCYTE ANTIGEN; LYSOZYME; MESSENGER RNA; PROGRAMMED DEATH 1 RECEPTOR; PROGRAMMED DEATH 2 RECEPTOR; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; TIM3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL SUBPOPULATION; CONTROLLED STUDY; EYE INFLAMMATION; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY INFILTRATE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; TH1 CELL; TH17 CELL;

ADOPTIVE TRANSFER; ANIMALS; APOPTOSIS; CELL LINE; EYE DISEASES; INFLAMMATION; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; TH1 CELLS; TH17 CELLS;

EID: 80054026726     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.08.006     Document Type: Article

References (24)

1. Cox C.A., Shi G., Yin H., Vistica B.P., Wawrousek E.F., Chan C.C., Gery I. Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J. Immunol. 2008, 180:7414-7422.
2. Kroenke M.A., Carlson T.J., Andjelkovic A.V., Segal B.M. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 2008, 205:1535-1541.
3. Luger D., Silver P.B., Tang J., Cua D., Chen Z., Iwakura Y., Bowman E.P., Sgambellone N.M., Chan C.C., Caspi R.R. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 2008, 205:799-810.
4. Zhu J., Yamane H., Paul W.E. Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol. 2010, 28:445-489.
5. Annunziato F., Romagnani S. The transient nature of the Th17 phenotype. Eur. J. Immunol. 2010, 40:3312-3316.
6. Murphy K.M., Stockinger B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat. Immunol. 2010, 11:674-680.
7. Shi G., Cox C.A., Vistica B.P., Tan C., Wawrousek E.F., Gery I. Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J. Immunol. 2008, 181:7205-7213.
8. Shi G., Ramaswamy M., Vistica B.P., Cox C.A., Tan C., Wawrousek E.F., Siegel R.M., Gery I. Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell death. J. Immunol. 2009, 183:7547-7556.
9. Yu Y., Iclozan C., Yamazaki T., Yang X., Anasetti C., Dong C., Yu X.Z. Abundant c-Fas-associated death domain-like interleukin-1-converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death. Blood 2009, 114:1026-1028.
10. Sohn S.J., Thompson J., Winoto A. Apoptosis during negative selection of autoreactive thymocytes. Curr. Opin. Immunol. 2007, 19:510-515.
11. Strasser A., Puthalakath H., O'Reilly L.A., Bouillet P. What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain. Immunol. Cell Biol. 2008, 86:57-66.
12. Green D.R., Droin N., Pinkoski M. Activation-induced cell death in T cells. Immunol. Rev. 2003, 193:70-81.
13. Siegel R.M., Chan F.K., Chun H.J., Lenardo M.J. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat. Immunol. 2000, 1:469-474.
14. Bouillet P., O'Reilly L.A. CD95, BIM and T cell homeostasis. Nat. Rev. Immunol. 2009, 9:514-519.
15. Huang D.C., Strasser A. BH3-only proteins - essential initiators of apoptotic cell death. Cell 2000, 103:839-842.
16. Antignani A., Youle R.J. How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?. Curr. Opin. Cell Biol. 2006, 18:685-689.
17. Gavathiotis E., Suzuki M., Davis M.L., Pitter K., Bird G.H., Katz S.G., Tu H.C., Kim H., Cheng E.H., Tjandra N., Walensky L.D. BAX activation is initiated at a novel interaction site. Nature 2008, 455:1076-1081.
18. Gonzalvez F., Ashkenazi A. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 2010, 29:4752-4765.
19. Strasser A., Jost P.J., Nagata S. The many roles of FAS receptor signaling in the immune system. Immunity 2009, 30:180-192.
20. Fife B.T., Pauken K.E. The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann. NY Acad. Sci. 2011, 1217:45-59.
21. Francisco L.M., Sage P.T., Sharpe A.H. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 2010, 236:219-242.
22. Zhu C., Anderson A.C., Schubart A., Xiong H., Imitola J., Khoury S.J., Zheng X.X., Strom T.B., Kuchroo V.K. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 2005, 6:1245-1252.
23. Lindsten T., Zong W.X., Thompson C.B. Defining the role of the Bcl-2 family of proteins in the nervous system. Neuroscientist 2005, 11:10-15.
24. Rickman D.W., Nacke R.E., Bowes Rickman C. Characterization of the cell death promoter, Bad, in the developing rat retina and forebrain. Brain Res. Dev. Brain Res. 1999, 115:41-47.