Isolation and structural elucidation of flibanserin as an adulterant in a health supplement used for female sexual performance enhancement

Journal of Pharmaceutical and Biomedical Analysis

Volumn 57, Issue 1, 2012, Pages 104-108

  Low, Min Yong ^a,b   Li, Lin ^a,b   Ge, Xiaowei ^b   Kee, Chee Leong ^b   Koh, Hwee Ling ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b HEALTH SCIENCES AUTHORITY   (Singapore)

Author keywords

Flibanserin; Health supplement; LC LTQ Orbitrap XL FTMS; NMR

Indexed keywords

FLIBANSERIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; INFRARED SPECTROMETRY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEXUAL BEHAVIOR;

BENZIMIDAZOLES; DIETARY SUPPLEMENTS; FEMALE; HUMANS; SEXUALITY;

EID: 80054019136     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.08.027     Document Type: Article

References (8)

1. Laumann E.O., Paik A., Rosen R.C. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999, 281:537-544.
2. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorder 2000, Washington DC, pp. 493-538. fourth ed.
3. Shifren J.L., Monz B.U., Russo P.A., Segreti A., Johannes C.B. Sexual problems and distress in United States women: prevalence and correlates. Obstet. Gynecol. 2008, 112:968-969.
4. Marwick C. Survey says patients expect little physician help on sex. JAMA 1999, 281:2173-2174.
5. Invernizzi R.W., Sacchetti G., Parini S., Acconcia S., Samanin R. Flibanserin, a potential antidepressant drug, lower 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors. Br. J. Pharmacol. 2003, 139:1281-1288.
6. Ferger B., Shimasaki M., Ceci A., Ittrich C., Kelly K.A., Sommer B. Flibanserin, a drug intended for treatment of hypoactive sexual desire disorder in pre-menopausal women, affects spontaneous motor activity and brain neurochemistry in female rats, Naunyn-Schmied. Arch. Pharmacol. 2010, 381:573-579.
7. Stahl S., Sommer B., Allers K. Multifunctional pharmacology of flibanserin: possible mechanism of therapeutic action in hypoactive sexual desire disorder. J. Sex Med. 2011, 8:15-27.
8. FDA, Summary Minutes of the Advisory Committee for Reproductive Health Drugs (18.06.10). Available at: (accessed 29.04.11). http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ReproductiveHealthDrugsAdvisoryCommittee/UCM248751.pdf.